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Synthetic Route

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Articles

Peer-Reviewed Papers

Effects of short-term treatment with pravastatin on the hepatic synthesis of cholesterol and bile acids in gallstone patients.C G Hillebrant et al.European journal of clinical investigation, 28(4), 324-328 (1998-06-06) Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial.Dana Friedrich et al.BMC gastroenterology, 18(1), 76-76 (2018-06-06) LC-MS/MS quantification of 7?-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma.Kang L, et al. Journal of Chromatography. B, Biomedical Sciences and Applications, 1064, 49-55 (2017) A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial.Marcos Pedrosa et al.Contemporary clinical trials, 88, 105889-105889 (2019-11-16) Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea.W G Brydon et al.European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01) Monitoring hepatic cholesterol 7?-hydroxylase activity by assay of the stable bile acid intermediate 7?-hydroxy-4-cholesten-3-one in peripheral blood.Galman C, et al. Journal of Lipid Research, 44(4), 859-866 (2003) LC-MS/MS quantification of 7α-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma.Lijuan Kang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1064, 49-55 (2017-09-16) Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers.Michael K Badman et al.Clinical pharmacology in drug development, 9(3), 395-410 (2019-12-12) A UHPLC-MS/MS method for the quantification of 7?-hydroxy-4-cholesten-3-one to assist in diagnosis of bile acid malabsorption.Prost JC, et al. Clinical mass spectrometry, 3, 1-6 (2017) Comparison of simple extraction procedures in liquid chromatography-mass spectrometry based determination of serum 7?-hydroxy-4-cholesten-3-one, a surrogate marker of bile acid synthesis.Marek L, et al. Journal of Chromatography. B, Biomedical Sciences and Applications, 1033, 317-320 (2016) Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS.Akira Honda et al.Journal of lipid research, 48(2), 458-464 (2006-11-10)

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