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7,8-Dihydro-8-oxo-pyrazino[2,3-d]pyridazine-5-acetic acid 1,1-dimethylethyl ester | CAS:1355612-95-1
7,8-Dihydro-8-oxo-pyrazino[2,3-d]pyridazine-5-acetic acid 1,1-dimethylethyl ester
  • Name:7,8-Dihydro-8-oxo-pyrazino[2,3-d]pyridazine-5-acetic acid 1,1-dimethylethyl ester
  • CAS:1355612-95-1
  • Synonyms:
  • Molecular Formula:C12H14N4O3
  • Molecular Weight:262.26
  • EINESC:

Description

Properties

Density 1.36±0.1 g/cm3 (20 ºC

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SDS

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Peer-Reviewed Papers
Chronic low backache and stiffness may not be due ankylosing spondylitis.Shahid Ahmed et al.JPMA. The Journal of the Pakistan Medical Association, 60(8), 681-683 (2010-08-24) Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi.Ya-Jun Guo et al.Food & function, 3(11), 1195-1205 (2012-08-08) Natural history of alkaptonuria revisited: analyses based on scoring systems.Lakshminarayan R Ranganath et al.Journal of inherited metabolic disease, 34(6), 1141-1151 (2011-07-13) Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes.Daniela Braconi et al.Journal of cellular biochemistry, 111(4), 922-932 (2010-07-29) Secreted pyomelanin of Legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions.Huaixin Zheng et al.Infection and immunity, 81(11), 4182-4191 (2013-08-28) Blue nevus of the prostate.Virginia L Dailey et al.Archives of pathology & laboratory medicine, 135(6), 799-802 (2011-06-03) The human gene for alkaptonuria (AKU) maps to chromosome 3q.S Janocha et al.Genomics, 19(1), 5-8 (1994-01-01) Aortic stenosis and vascular calcifications in alkaptonuria.Hwaida Hannoush et al.Molecular genetics and metabolism, 105(2), 198-202 (2011-11-22) Biotransformation of Cranberry Proanthocyanidins to Probiotic Metabolites by Lactobacillus rhamnosus Enhances Their Anticancer Activity in HepG2 Cells In Vitro.H P Vasantha Rupasinghe et al.Oxidative medicine and cellular longevity, 2019, 4750795-4750795 (2019-07-19) [Important bilateral corneal astigmatism in a case of ocular ochronosis].A Ehongo et al.Bulletin de la Societe belge d'ophtalmologie, (295)(295), 17-21 (2005-04-27) Development of an in vitro model to investigate joint ochronosis in alkaptonuria.Laura Tinti et al.Rheumatology (Oxford, England), 50(2), 271-277 (2010-10-19) DFT for exploring the antioxidant potential of homogentisic and orsellinic acids.Muhammad Saqib et al.Pakistan journal of pharmaceutical sciences, 26(6), 1209-1214 (2013-11-06) A quantitative assessment of alkaptonuria: testing the reliability of two disease severity scoring systems.Trevor F Cox et al.Journal of inherited metabolic disease, 34(6), 1153-1162 (2011-07-12) Diagnosis of alcaptonuria: rapid analysis of homogentisic acid by HPLC.C Bory et al.Clinica chimica acta; international journal of clinical chemistry, 189(1), 7-11 (1990-07-01) Electrooxidation of homogentisic acid in aqueous and mixed solvent solutions: experimental and theoretical studies.Marzieh Eslami et al.The journal of physical chemistry. B, 117(9), 2757-2763 (2013-02-07) Clinical images: Magnetic resonance imaging appearance of alkaptonuria.Shahir S Hamdulay et al.Arthritis and rheumatism, 64(1), 129-129 (2011-09-29) Pediatric Dermatology E-Book, 507-507 (2011) Alkaptonuria.Molly Yancovitz et al.Dermatology online journal, 16(11), 6-6 (2010-12-18) The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.A M Taylor et al.Arthritis and rheumatism, 63(12), 3887-3896 (2011-12-01) Natural history of alkaptonuria.Chanika Phornphutkul et al.The New England journal of medicine, 347(26), 2111-2121 (2002-12-27) Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila.Yaping Wang et al.BMC microbiology, 17(1), 122-122 (2017-05-27) A novel ex vivo organotypic culture model of alkaptonuria-ochronosis.L Tinti et al.Clinical and experimental rheumatology, 29(4), 693-696 (2011-08-05) Development and Validation of a GC-MS Method for the Analysis of Homogentisic Acid in Strawberry Tree (Irena Brčić Karačonji et al.Journal of AOAC International, 100(4), 889-892 (2017-06-01) Homogentisic acid and structurally related compounds as intermediates in plasma soluble melanin formation and in tissue toxicities.Z L Hegedus et al.Archives internationales de physiologie, de biochimie et de biophysique, 102(3), 175-181 (1994-05-01) Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice.Shuzhang Yang et al.Proceedings of the National Academy of Sciences of the United States of America, 116(44), 22229-22236 (2019-10-16) Homogentisic acid autoxidation and oxygen radical generation: implications for the etiology of alkaptonuric arthritis.Martin Jr, et al. Free Radical Biology & Medicine, 3(4), 241-250 (1987) A 3-year randomized therapeutic trial of nitisinone in alkaptonuria.Wendy J Introne et al.Molecular genetics and metabolism, 103(4), 307-314 (2011-05-31) Mechanisms of interference of p-diphenols with the Trinder reaction.Damian Tarasek et al.Bioorganic chemistry, 97, 103692-103692 (2020-03-11) Anticholinesterase activity of selected phenolic acids and flavonoids - interaction testing in model solutions.Dominik Szwajgier Annals of agricultural and environmental medicine : AAEM, 22(4), 690-694 (2015-12-29) False proteinuria in patients with alkaptonuria.E Selvi et al.Clinical and experimental rheumatology, 28(4), 591-591 (2010-07-28) A putative ABC transporter, hatABCDE, is among molecular determinants of pyomelanin production in Pseudomonas aeruginosa.Ryan C Hunter et al.Journal of bacteriology, 192(22), 5962-5971 (2010-09-28) Alkaptonuria and renal failure: a case report and review of the literature.V S Venkataseshan et al.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 5(4), 464-471 (1992-07-01) Facile synthesis of molecularly imprinted polymers for selective extraction of tyrosine metabolites in human urine.Xianyu Liang et al.Journal of chromatography. A, 1587, 34-41 (2018-12-16) Ashy ears.Efstathios Rallis et al.TheScientificWorldJournal, 10, 1530-1531 (2010-08-10) Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis.Daniela Braconi et al.Journal of inherited metabolic disease, 34(6), 1163-1176 (2011-08-30) Alkaptonuria is a novel human secondary amyloidogenic disease.Lia Millucci et al.Biochimica et biophysica acta, 1822(11), 1682-1691 (2012-08-02) An update on molecular genetics of Alkaptonuria (AKU).Andrea Zatkova Journal of inherited metabolic disease, 34(6), 1127-1136 (2011-07-02) Mass spectrometric behavior of phenolic acids standards and their analysis in the plant samples with LC/ESI/MS system.Wojciech Ostrowski et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 21-27 (2014-07-27) Black aorta in a patient with alkaptonuria (ochronosis).Giovanni Concistrè et al.Journal of cardiovascular medicine (Hagerstown, Md.), 12(6), 444-445 (2011-03-19) 4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme.Corinne Raspail et al.The Journal of biological chemistry, 286(29), 26061-26070 (2011-05-27) Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.J D Shoemaker et al.Journal of chromatography, 562(1-2), 125-138 (1991-01-02) The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400.Valentina Méndez et al.PloS one, 6(3), e17583-e17583 (2011-03-23) Quantitation of homogentisic acid in normal human plasma.J C Deutsch et al.Journal of chromatography. B, Biomedical applications, 677(1), 147-151 (1996-02-23) Determination of HPLC-UV Fingerprints of Spanish Paprika (Capsicum annuum L.) for Its Classification by Linear Discriminant Analysis.Xavier Cetó et al.Sensors (Basel, Switzerland), 18(12) (2018-12-21) Evaluation of the interference by homogentisic acid and other organic acids on the enzymatic and Jaffé method creatinine assay.Steven Pauwels et al.Clinical chemistry and laboratory medicine, 50(4), 749-750 (2012-04-17)
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