Density	1.193±0.06 g/cm3 (20 º

没有数据	没有数据

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats.Beatrice Nyanchama Kiage-Mokua et al.Phytotherapy research : PTR, 26(12), 1878-1883 (2012-03-21) Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.Wolfgang Kandioller et al.Chemical communications (Cambridge, England), 49(32), 3348-3350 (2013-03-19) Acanthamoeba castellanii Neff: In vitro activity against the trophozoite stage of a natural sesquiterpene and a synthetic cobalt(II)-lapachol complex.Carmen M Martín-Navarro et al.Experimental parasitology, 126(1), 106-108 (2010-01-05) Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells.Eduardo J S Salustiano et al.Investigational new drugs, 28(2), 139-144 (2009-03-04) A proteomic insight into the effects of the immunomodulatory hydroxynaphthoquinone lapachol on activated macrophages.Renato A S Oliveira et al.International immunopharmacology, 14(1), 54-65 (2012-06-19) Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.Mariano Walter Pertino et al.Molecules (Basel, Switzerland), 16(10), 8614-8628 (2011-10-15) Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts.W F Costa et al.Genetics and molecular research : GMR, 10(4), 3236-3245 (2011-12-24) Structural elucidation of the metabolites of lapachol in rats by liquid chromatography-tandem mass spectrometry.Lu Bai et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 944, 128-135 (2013-12-10) Quinones derived from plant secondary metabolites as anti-cancer agents.Jin-Jian Lu et al.Anti-cancer agents in medicinal chemistry, 13(3), 456-463 (2012-08-31) Lapachol induces clastogenic effects in rats.Edson Luis Maistro et al.Planta medica, 76(9), 858-862 (2010-01-30) LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma.Sanjay Gurule et al.Biomedical chromatography : BMC, 24(5), 497-505 (2009-08-28) Biomimetic in vitro oxidation of lapachol: a model to predict and analyse the in vivo phase I metabolism of bioactive compounds.Michael Niehues et al.European journal of medicinal chemistry, 54, 804-812 (2012-07-17) Gas-phase reactivity of 2-hydroxy-1,4-naphthoquinones: a computational and mass spectrometry study of lapachol congeners.Ricardo Vessecchi et al.Journal of mass spectrometry : JMS, 47(12), 1648-1659 (2013-01-03) Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.Cristian Salas et al.Bioorganic & medicinal chemistry, 16(2), 668-674 (2007-11-22) Development of lapachol topical formulation: anti-inflammatory study of a selected formulation.Ana Amélia M Lira et al.AAPS PharmSciTech, 9(1), 163-168 (2008-05-01) The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages.Renato A S Oliveira et al.International immunopharmacology, 10(11), 1463-1473 (2010-09-15) Inactivation of β-Lapachone Cytotoxicity by Filamentous Fungi that Mimic the Human Blood Metabolism.Camila Raquel Paludo et al.European journal of drug metabolism and pharmacokinetics, 42(2), 213-220 (2016-04-10) Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.Evelyn L Bonifazi et al.Bioorganic & medicinal chemistry, 18(7), 2621-2630 (2010-03-23) Anti-biofilm Effect of β-Lapachone and Lapachol Oxime Against Isolates of Staphylococcus aureus.Antônio Wilton Cavalcante Fernandes et al.Current microbiology, 77(2), 204-209 (2019-12-01) Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars.Takuya Matsui et al.The Journal of pharmacy and pharmacology, 63(7), 960-966 (2011-06-04) Antimony(V) and bismuth(V) complexes of lapachol: synthesis, crystal structure and cytotoxic activity.Ludmila G de Oliveira et al.Molecules (Basel, Switzerland), 16(12), 10314-10323 (2011-12-14) Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol.Masayo Maeda et al.Toxicology and applied pharmacology, 229(2), 232-238 (2008-02-26) Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe.Ricardo Q Aucélio et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 100, 155-160 (2012-05-18) Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures.Cristina Theoduloz et al.Planta medica, 78(17), 1807-1812 (2012-10-11) Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities.Gabrieli L Parrilha et al.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 25(1), 55-62 (2011-08-09) Fragmentation studies and electrospray ionization mass spectrometry of lapachol: protonated, deprotonated and cationized species.Ricardo Vessecchi et al.Rapid communications in mass spectrometry : RCM, 24(14), 2101-2108 (2010-06-17) Synthetic lapachol derivatives relax guinea-pig ileum by blockade of the voltage-gated calcium channels.Fabiana de A Cavalcante et al.Zeitschrift fur Naturforschung. C, Journal of biosciences, 65(9-10), 627-636 (2010-12-09) Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells.Lucas Bonfim Marques et al.Toxicology in vitro : an international journal published in association with BIBRA, 65, 104772-104772 (2020-01-15) Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells.Xueyin Zu et al.Phytotherapy research : PTR, 33(9), 2337-2346 (2019-06-22) Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol.Marcele Neves Rocha et al.Bioinorganic chemistry and applications, 2013, 961783-961783 (2013-06-20) Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.Kenneth O Eyong et al.Bioorganic & medicinal chemistry letters, 18(20), 5387-5390 (2008-10-03) Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1.Ingrid L Cockburn et al.Biological chemistry, 392(5), 431-438 (2011-03-24)

Remarks