Density	1.331±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.Rajagopal S, et al. Journal of Experimental Therapeutics & Oncology, 3(3), 147-158 (2003) Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.Mayur M Uttekar et al.European journal of medicinal chemistry, 56, 368-374 (2012-08-04) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.Jonathan Chee Woei Lim et al.Clinical and experimental pharmacology & physiology, 39(3), 300-310 (2011-10-25) Elicitation of andrographolide in the suspension cultures of Andrographis paniculata.Suryakala Gandi et al.Applied biochemistry and biotechnology, 168(7), 1729-1738 (2012-09-25) Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7.Hai-Ying Ma et al.Toxicology and applied pharmacology, 277(1), 86-94 (2014-03-19) Eugenie Mussard et al.Antioxidants (Basel, Switzerland), 9(5) (2020-05-21)Andrographis paniculata (Burm.f.) has long been used in ayurvedic medicine through its anti-inflammatory properties. However, its protective effect of skin aging has not been studied in vitro. This study aimed to investigate the anti-aging effects of methanolic extract (ME), andrographolide... A green method using a micellar system for determination of andrographolide and dehydroandrographolide in human plasma.Qi Zhao et al.Journal of chromatographic science, 51(4), 341-348 (2012-09-15) Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.Wei Chen et al.Carcinogenesis, 33(11), 2190-2198 (2012-08-08) Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells.R Krithika et al.Human & experimental toxicology, 32(5), 530-543 (2012-10-02) Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways.Wenjie Guo et al.International immunopharmacology, 14(4), 613-619 (2012-10-06) Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011).Chantana Aromdee Expert opinion on therapeutic patents, 22(2), 169-180 (2012-02-15) [Preliminary study of effects of andrographolide on Staphylococcus epidermidis biofilms].Yan Guan et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(14), 2147-2150 (2012-11-07) Biological activities and corresponding SARs of andrographolide and its derivatives.Bin Zhou et al.Mini reviews in medicinal chemistry, 13(2), 298-309 (2013-02-27) Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.Emil Salim et al.Journal of natural medicines, 68(3), 647-653 (2014-05-07) Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.Shen K, Ji L, Lu B, et al. Chemico-Biological Interactions, 218, 99-106 (2014) Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.Haw-Wen Chen et al.Toxicology and applied pharmacology, 280(1), 1-9 (2014-08-12) Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.Xiang Li et al.Neuropharmacology, 141, 305-315 (2018-09-16) Andrographolide modulates HNF4α activity imparting on hepatic metabolism.Minyi Zhang et al.Molecular and cellular endocrinology, 513, 110867-110867 (2020-05-19) Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.Guo-Qing Bao et al.Toxicology letters, 222(1), 23-35 (2013-07-13) Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.Zhong Rong Zhang et al.PloS one, 8(1), e54577-e54577 (2013-02-06) Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines.Nurhanan M Yunos et al.Anticancer research, 33(10), 4365-4371 (2013-10-15) Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC.Partha Roy et al.Current pharmaceutical biotechnology, 13(15), 2669-2681 (2012-10-18) Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata.Rajesh Chandra Misra et al.Plant science : an international journal of experimental plant biology, 240, 50-64 (2015-10-18) Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.Tao Zhu et al.PloS one, 8(2), e56407-e56407 (2013-02-26) [Advances in pharmacological study of andrographolide and its derivatives].Xinjian Liu et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 26(2), 135-138 (2003-09-16) Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Handa SS and Sharma A. The Indian Journal of Medical Research, 92, 276-283 (1990) [Structure and properties of proprotein convertase inhibitors].V K Kibirev et al.Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(2), 5-29 (2012-05-31) Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.Harrison J Hocker et al.Proceedings of the National Academy of Sciences of the United States of America, 110(25), 10201-10206 (2013-06-06) Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.X P Li et al.Drug research, 63(5), 258-262 (2013-03-30) Andrographolide sodium bisulphite-induced inactivation of urease: inhibitory potency, kinetics and mechanism.Zhi-Zhun Mo et al.BMC complementary and alternative medicine, 15, 238-238 (2015-07-17) Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.Jian Gao et al.Cell death & disease, 10(12), 957-957 (2019-12-22) Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway.Lili Ding et al.The Journal of pharmacology and experimental therapeutics, 351(2), 474-483 (2014-09-11) Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.Wan J Lu et al.Biochemical pharmacology, 84(7), 914-924 (2012-07-10) [Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years].Yuan-Yuan Yan et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(22), 3819-3824 (2014-02-25) [Study on andrographolide solid dispersion vectored by hydroxyapatite].Shao-Ying Hu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 341-345 (2013-05-15) In vitro and in vivo anti-inflammatory effects of andrographolide.Abu-Ghefreh Ala'AA, et al. International Immunopharmacology, 9(3), 313-318 (2009) Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling.Eva Ramos-Fernández et al.Molecular neurobiology, 56(3), 1870-1882 (2018-07-04) Activity of andrographolide against dengue virus.Panraksa P, et al. Antiviral Research, 139, 69-78 (2017) Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.Minghua Yang et al.Journal of pharmaceutical and biomedical analysis, 70, 87-93 (2012-06-29) Anti-tumor initiating potential of andrographolide in 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.S Manoharan et al.Asian Pacific journal of cancer prevention : APJCP, 13(11), 5701-5708 (2013-01-16) Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.Chia-Yang Lu et al.Biochemical pharmacology, 91(1), 40-50 (2014-07-08) Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis.Sun-Wei Guo et al.Fertility and sterility, 99(1), 231-240 (2012-09-25) Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.Shuang-Qing Zhang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 173-177 (2012-09-27) A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.Yong-Yang Zhu et al.Proteomics, 13(1), 169-178 (2012-11-20) A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis.Ting-Lin Yen et al.Pharmaceutical biology, 51(9), 1150-1157 (2013-08-13) Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide.Yonglei Yuan et al.Fitoterapia, 83(8), 1506-1513 (2012-09-11) Cell type-dependent effects of andrographolide on human cancer cell lines.Myra T W Cheung et al.Life sciences, 91(15-16), 751-760 (2012-10-11) Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway.S Kumar et al.Current molecular medicine, 12(8), 952-966 (2012-07-19) [Advances in study on anti-tumor mechanism of andrographolide].Cui-Ling Qi et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32(20), 2095-2097 (2008-03-01) Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats.Tao Yang et al.Phytotherapy research : PTR, 27(4), 618-623 (2012-06-30)

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