Density	1.130±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.Kurt Schmidt et al.Biochemical pharmacology, 90(3), 246-253 (2014-05-28) Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.Arafat Nasser et al.Molecular pain, 9, 5-5 (2013-02-21) Cytotoxicity of 6-biopterin to human melanocytes.K U Schallreuter et al.Biochemical and biophysical research communications, 204(1), 43-48 (1994-10-14) Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.Visnu Chaparro et al.Infection and immunity, 87(5) (2019-02-26) Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.Jennifer Whitsett et al.Free radical biology & medicine, 63, 143-150 (2013-05-28) Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.Ubaldo Armato et al.Biochimica et biophysica acta, 1832(10), 1634-1652 (2013-05-01) Defective calcium transport in vitiliginous melanocytes.K U Schallreuter-Wood et al.Archives of dermatological research, 288(1), 11-13 (1996-01-01) Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells.Shaojun Yang et al.The Journal of biological chemistry, 288(26), 19221-19237 (2013-05-04) Polarization-resolved second-harmonic generation microscopy as a method to visualize protein-crystal domains.Emma L DeWalt et al.Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 74-81 (2013-01-01) Phenylalanine hydroxylase: function, structure, and regulation.Marte I Flydal et al.IUBMB life, 65(4), 341-349 (2013-03-05) Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.Patricia Almudéver et al.Thorax, 68(10), 938-948 (2013-06-07) Use of sapropterin in the management of phenylketonuria: seven case reports.H Gokmen Ozel et al.Molecular genetics and metabolism, 108(2), 109-111 (2012-12-26) Leishmania braziliensis SCD6 and RBP42 proteins, two factors with RNA binding capacity.Paola A Nocua et al.Parasites & vectors, 10(1), 610-610 (2017-12-21) Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.Javier Inserte et al.Journal of the American Heart Association, 2(1), e005975-e005975 (2013-03-26) Tetrahydrobiopterin in nitric oxide synthase.Jesús Tejero et al.IUBMB life, 65(4), 358-365 (2013-02-27) Vascular function during prolonged progression and regression of atherosclerosis in mice.Jordan D Miller et al.Arteriosclerosis, thrombosis, and vascular biology, 33(3), 459-465 (2013-01-12) Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.Kengo Kidokoro et al.Journal of the American Society of Nephrology : JASN, 24(7), 1139-1150 (2013-04-27) Long-term follow-up and outcome of phenylketonuria patients on sapropterin: a retrospective study.Stefanie Keil et al.Pediatrics, 131(6), e1881-e1888 (2013-05-22) Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice.Christopher Welsh et al.American journal of physiology. Gastrointestinal and liver physiology, 305(1), G47-G57 (2013-05-04) Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.Kin Lung Siu et al.American journal of physiology. Heart and circulatory physiology, 307(11), H1559-H1564 (2014-09-28) Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.Ziad A Ali et al.Circulation, 128(11 Suppl 1), S50-S58 (2013-10-18) Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.Magdalena Strobl et al.American journal of physiology. Lung cellular and molecular physiology, 305(7), L485-L490 (2013-07-31) Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.Hirohito Haruki et al.Science (New York, N.Y.), 340(6135), 987-991 (2013-05-25) The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.Joo-Yong Jung et al.Infection and immunity, 81(9), 3198-3209 (2013-06-19) Phenylalanine hydroxylase deficiency in the Slovak population: genotype-phenotype correlations and genotype-based predictions of BH4-responsiveness.Emil Polak et al.Gene, 526(2), 347-355 (2013-06-15) The regulation of vascular tetrahydrobiopterin bioavailability.Anna Starr et al.Vascular pharmacology, 58(3), 219-230 (2013-05-02) Alkylglycerol monooxygenase.Katrin Watschinger et al.IUBMB life, 65(4), 366-372 (2013-02-27) Structures and reaction mechanisms of GTP cyclohydrolases.Tobias Gräwert et al.IUBMB life, 65(4), 310-322 (2013-03-05) The neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons.Gregory Kapatos IUBMB life, 65(4), 323-333 (2013-03-05) Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells.Shaojun Yang et al.The Journal of biological chemistry, 288(26), 19221-19237 (2013-05-04) Tetrahydrobiopterin in nitric oxide synthase.Jesús Tejero et al.IUBMB life, 65(4), 358-365 (2013-02-27) Use of sapropterin in the management of phenylketonuria: seven case reports.H Gokmen Ozel et al.Molecular genetics and metabolism, 108(2), 109-111 (2012-12-26) Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.Kurt Schmidt et al.Biochemical pharmacology, 90(3), 246-253 (2014-05-28) Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.Javier Inserte et al.Journal of the American Heart Association, 2(1), e005975-e005975 (2013-03-26) Defective calcium transport in vitiliginous melanocytes.K U Schallreuter-Wood et al.Archives of dermatological research, 288(1), 11-13 (1996-01-01) Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.Patricia Almudéver et al.Thorax, 68(10), 938-948 (2013-06-07) Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.Arafat Nasser et al.Molecular pain, 9, 5-5 (2013-02-21) Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.Ubaldo Armato et al.Biochimica et biophysica acta, 1832(10), 1634-1652 (2013-05-01) Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.Kengo Kidokoro et al.Journal of the American Society of Nephrology : JASN, 24(7), 1139-1150 (2013-04-27) Cytotoxicity of 6-biopterin to human melanocytes.K U Schallreuter et al.Biochemical and biophysical research communications, 204(1), 43-48 (1994-10-14) Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.Ziad A Ali et al.Circulation, 128(11 Suppl 1), S50-S58 (2013-10-18) Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.Hirohito Haruki et al.Science (New York, N.Y.), 340(6135), 987-991 (2013-05-25) Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.Magdalena Strobl et al.American journal of physiology. Lung cellular and molecular physiology, 305(7), L485-L490 (2013-07-31) Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.Kin Lung Siu et al.American journal of physiology. Heart and circulatory physiology, 307(11), H1559-H1564 (2014-09-28) Leishmania braziliensis SCD6 and RBP42 proteins, two factors with RNA binding capacity.Paola A Nocua et al.Parasites & vectors, 10(1), 610-610 (2017-12-21) Phenylalanine hydroxylase: function, structure, and regulation.Marte I Flydal et al.IUBMB life, 65(4), 341-349 (2013-03-05) Polarization-resolved second-harmonic generation microscopy as a method to visualize protein-crystal domains.Emma L DeWalt et al.Acta crystallographica. Section D, Biological crystallography, 69(Pt 1), 74-81 (2013-01-01) Long-term follow-up and outcome of phenylketonuria patients on sapropterin: a retrospective study.Stefanie Keil et al.Pediatrics, 131(6), e1881-e1888 (2013-05-22) Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.Jennifer Whitsett et al.Free radical biology & medicine, 63, 143-150 (2013-05-28) Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice.Christopher Welsh et al.American journal of physiology. Gastrointestinal and liver physiology, 305(1), G47-G57 (2013-05-04) Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.Visnu Chaparro et al.Infection and immunity, 87(5) (2019-02-26) The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.Joo-Yong Jung et al.Infection and immunity, 81(9), 3198-3209 (2013-06-19) Alkylglycerol monooxygenase.Katrin Watschinger et al.IUBMB life, 65(4), 366-372 (2013-02-27) Structures and reaction mechanisms of GTP cyclohydrolases.Tobias Gräwert et al.IUBMB life, 65(4), 310-322 (2013-03-05) Phenylalanine hydroxylase deficiency in the Slovak population: genotype-phenotype correlations and genotype-based predictions of BH4-responsiveness.Emil Polak et al.Gene, 526(2), 347-355 (2013-06-15) The regulation of vascular tetrahydrobiopterin bioavailability.Anna Starr et al.Vascular pharmacology, 58(3), 219-230 (2013-05-02) The neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons.Gregory Kapatos IUBMB life, 65(4), 323-333 (2013-03-05) Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase.Georges Chreifi et al.Biochemistry, 53(25), 4216-4223 (2014-05-14)

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