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1-[4-[5-[5-Amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one | CAS:1620576-64-8
1-[4-[5-[5-Amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one
  • Name:1-[4-[5-[5-Amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one
  • CAS:1620576-64-8
  • Synonyms:
  • Molecular Formula:C22H31N9O3
  • Molecular Weight:469.54
  • EINESC:

Description

Properties

Density 1.45±0.1 g/cm3 (20 ºC

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Peer-Reviewed Papers
Isocyanate binding to yeast glutathione reductase measured by fluorescence spectroscopy.K J Baylor et al.Biochemical Society transactions, 25(1), 47S-47S (1997-02-01) Uniform small graphene oxide as an efficient cellular nanocarrier for immunostimulatory CpG oligonucleotides.Jinli Sun et al.ACS applied materials & interfaces, 6(10), 7926-7932 (2014-04-10) Biotransformation of carcinogenic arylamines and arylamides by human placenta.L O Derewlany et al.The Journal of laboratory and clinical medicine, 124(1), 134-141 (1994-07-01) 1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems.K Becker et al.Methods in enzymology, 251, 173-188 (1995-01-01) Cloning and expression of a PKC-regulated chloride channel.S Uchida et al.The Japanese journal of physiology, 44 Suppl 2, S55-S62 (1994-01-01) Synthesis and evaluation of several new (2-chloroethyl) nitrosocarbamates as potential anticancer agentsReynolds RC, et al. Journal of Medicinal Chemistry, 43.8, 1484-1488 (2000) Inhibition of protein A24 lyase by nitrosoureas.G Markussen et al.FEBS letters, 176(2), 426-430 (1984-10-29) Inhibition of carboxyethylphosphoramide mustard formation from 4-hydroxycyclophosphamide by carmustine.S Ren et al.AAPS pharmSci, 1(3), E14-E14 (2001-12-14) Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro.M R Davis et al.Chemical research in toxicology, 6(3), 376-383 (1993-05-01) Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one, a novel broad-spectrum antitumor agentStevens, Malcolm FG, et al. Journal of Medicinal Chemistry, 27.2, 196-201 (1984) Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates.C Dive et al.Biochemical pharmacology, 36(21), 3731-3738 (1987-11-01) Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.W F Brubaker et al.Biochemical pharmacology, 35(14), 2359-2365 (1986-07-15) Microwave spectrum and conformational composition of 2-chloroethylisocyanide.Harald Møllendal et al.The journal of physical chemistry. A, 115(46), 13474-13481 (2011-10-13) Synthesis, metabolism, and antitumor activity of deuterated analogs of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoureaFarmer PB, et al. Journal of Medicinal Chemistry, 21.6, 514-520 (1978) A new class of nitrosoureas. 4. Synthesis and antitumor activity of disaccharide derivatives of 3, 3-disubstituted 1-(2-chloroethyl)-1-nitrosoureasTsujihara, Kenji, et al. Journal of Medicinal Chemistry, 25.4, 441-446 (1982) Reactions of 1, 3-bis (2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solutionWeinkam RJ and Lin HS. Journal of Medicinal Chemistry, 22.10, 1193-1198 (1979) Action of carbamoylating agents on the uptake of metabolites in hepatomas and liver.M A Lea et al.Biochemical pharmacology, 36(17), 2775-2781 (1987-09-01)
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