Melting point	132-136 ºC
Water Solubility	0.08 g/100 mL (20 ºC)

Symbol(GHS)	Xi;N
Hazard Codes	R36/37/38;R51/53
SDS/MSDS	S26;S36/37;S60;S61

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor-independent process in hippocampal slices.E Albiñana et al.Pflugers Archiv : European journal of physiology, 469(5-6), 779-795 (2017-02-09) Modulation of alpha-synuclein aggregation by dopamine analogs.Diane Latawiec et al.PloS one, 5(2), e9234-e9234 (2010-02-20) Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism.Abdelahad Khajo et al.PloS one, 6(9), e25092-e25092 (2011-10-04) Evaluation of three temperature- and mobile phase-dependent retention models for reversed-phase liquid chromatographic retention and apparent retention enthalpy.Anthony R Horner et al.Journal of chromatography. A, 1589, 73-82 (2019-01-11) Pharmacokinetic properties of the synthetic cannabinoid JWH-018 in oral fluid after inhalation.Stefan W Toennes et al.Drug testing and analysis, 10(4), 644-650 (2017-10-03) Melatonin plays a protective role in postburn rodent gut pathophysiology.Walid M Al-Ghoul et al.International journal of biological sciences, 6(3), 282-293 (2010-06-23) [Development of novel fluorescence-derivatization-HPLC methods enabling highly sensitive and selective analysis of biological compounds].Kenichiro Todoroki Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(8), 1207-1211 (2011-08-02) 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition.Matthew LaPorte et al.The Journal of organic chemistry, 78(1), 167-174 (2012-11-10) Exploring QSARs for 5-lipoxygenase (5-LO) inhibitory activity of 2-substituted 5-hydroxyindole-3-carboxylates by CoMFA and CoMSIA.Junxia Zheng et al.Chemical biology & drug design, 78(2), 314-321 (2011-05-24) Simultaneous analysis of 29 synthetic cannabinoids and metabolites, amphetamines, and cannabinoids in human whole blood by liquid chromatography-tandem mass spectrometry - A New Zealand perspective of use in 2018.Rui Shen Ong et al.Drug testing and analysis, 12(2), 195-214 (2019-10-09) Determination of selected synthetic cannabinoids and their metabolites by micellar electrokinetic chromatography--mass spectrometry employing perfluoroheptanoic acid-based micellar phase.Martin Švidrnoch et al.Talanta, 150, 568-576 (2016-02-04) Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor.Masafumi Komiya et al.Bioorganic & medicinal chemistry, 20(23), 6840-6847 (2012-10-24) Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.Matthew R Skelton et al.PloS one, 6(1), e16187-e16187 (2011-01-21) Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.Jens Halvard Grønlien et al.Molecular pharmacology, 72(3), 715-724 (2007-06-15) Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.Yoshimitsu Yamazaki et al.Zeitschrift fur Naturforschung. C, Journal of biosciences, 65(1-2), 49-54 (2010-04-02) Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.Dimitrios Andreou et al.Psychiatry research, 180(2-3), 63-67 (2010-06-29) High-performance liquid chromatography with fluorescence detection and ultra-performance liquid chromatography with electrospray tandem mass spectrometry method for the determination of indoleamine neurotransmitters and their metabolites in sea lamprey plasma.Huiyong Wang et al.Analytica chimica acta, 721, 147-153 (2012-03-13) Simultaneous determination of 5-hydroxyindoles and catechols from urine using polymer monolith microextraction coupled to high-performance liquid chromatography with fluorescence detection.Yu-Bo Wu et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(20-21), 1847-1855 (2009-06-02) Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors.Andrew D Schweitzer et al.PloS one, 4(9), e7229-e7229 (2009-10-01) The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole.Xiang-Qun Hu et al.Neuropharmacology, 54(8), 1153-1165 (2008-04-26) A Fast and Comprehensive Analysis of 32 Synthetic Cannabinoids Using Agilent Triple Quadrupole LC-MS-MS.Damon Borg et al.Journal of analytical toxicology, 41(1), 6-16 (2016-09-30) Following the excited state relaxation dynamics of indole and 5-hydroxyindole using time-resolved photoelectron spectroscopy.Ruth Livingstone et al.The Journal of chemical physics, 135(19), 194307-194307 (2011-11-25) Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.Susana Sadler Simões et al.Forensic science international, 243, 117-125 (2014-08-16) Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.Jens Halvard Grønlien et al.European journal of pharmacology, 647(1-3), 37-47 (2010-09-08) Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.Eva-Maria Karg et al.Journal of medicinal chemistry, 52(11), 3474-3483 (2009-06-06) Stereoselective effect of kynurenine enantiomers on the excretion of serotonin and its metabolite in rat urine.Tsukasa Sasaki et al.Chirality, 22(2), 258-261 (2009-06-06) A separation of tyramine on a 2-(4-methoxyphenyl)ethylamine imprinted polymer: an answer from theoretical and experimental studies.Piotr Luliński et al.Talanta, 129, 155-164 (2014-08-17) Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795.Gretchen Y López-Hernández et al.Neuropharmacology, 56(4), 821-830 (2009-08-26) Molecular function of the novel α7β2 nicotinic receptor.Beatriz E Nielsen et al.Cellular and molecular life sciences : CMLS, 75(13), 2457-2471 (2018-01-10) The anti-apoptotic action of 5-hydroxyindole: protection of mitochondrial integrity.Sung Jin Bae et al.Biological & pharmaceutical bulletin, 33(4), 550-555 (2010-04-23) [Determination of 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline, 5-hydroxytryptamine and 5-hydroxyindole acetic acid in the neonatal rat brains using high performance iquid chromatography-electrochemical detection].Jian Mao et al.Se pu = Chinese journal of chromatography, 27(2), 216-219 (2009-07-25) CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: generation of homology model and docking studies.P Aparoy et al.Bioorganic & medicinal chemistry letters, 21(1), 456-462 (2010-11-19) Microsecond analysis of transient molecules using bi-directional capillary electrophoresis.Eric T Ritschdorff et al.Analytical chemistry, 81(21), 8790-8796 (2009-10-31) Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy?F Moroni et al.Advances in experimental medicine and biology, 420, 57-73 (1997-01-01) Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer.Jeffrey S Thinschmidt et al.Brain research, 1203, 51-60 (2008-03-07) Animal Models of Metabolic Epilepsy and Epilepsy Associated Metabolic Dysfunction: A Systematic Review.Uday Praful Kundap et al.Pharmaceuticals (Basel, Switzerland), 13(6) (2020-05-30) Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction.Yusuke Yamagishi et al.Chembiochem : a European journal of chemical biology, 10(9), 1469-1472 (2009-05-28) Electronic structure of 5-hydroxyindole: from gas phase to explicit solvation.David Robinson et al.The journal of physical chemistry. B, 113(8), 2535-2541 (2009-02-07)

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