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Difluoromethane | CAS:75-10-5
Difluoromethane
  • Name:Difluoromethane
  • CAS:75-10-5
  • Synonyms:
  • Molecular Formula:CH2F2
  • Molecular Weight:52.02
  • EINESC:200-839-4

Description

Properties

Melting point -136 ºC
Boiling point -51.7 ºC
Density 1.10

Safety

Symbol(GHS) F
Hazard Codes R11
SDS/MSDS S9;S16;S33

SDS

Source SDS/MSDS Samples
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Synthetic Route
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Articles
Peer-Reviewed Papers
Rational design of novel, potent small molecule pan-selectin antagonists.Remo Kranich et al.Journal of medicinal chemistry, 50(6), 1101-1115 (2007-02-17) Alleviation of hepatic injury by chrysin in cisplatin administered rats: probable role of oxidative and inflammatory markers.Muneeb U Rehman et al.Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03) 2-Aminoresorcinol is a potent alpha-glucosidase inhibitor.Hong Gao et al.Bioorganic & medicinal chemistry letters, 18(2), 812-815 (2007-11-28) Antioxidant and metabolism responses to polyphenol stress in cyanobacterium Microcystis aeruginosa.Li X Ni et al.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 48(2), 153-161 (2013-01-12) The effect of pyrogallic acid on growth, oxidative stress, and gene expression in Cylindrospermopsis raciborskii (Cyanobacteria).Zhongxing Wu et al.Ecotoxicology (London, England), 22(2), 271-278 (2012-11-28) Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function.R Sorrentino et al.British journal of pharmacology, 154(4), 864-871 (2008-06-10) Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria).C Flavia Massaro et al.Phytotherapy research : PTR, 29(1), 48-58 (2014-09-19) Molecular encapsulation in pyrogallolarene hexamers under nonequilibrium conditions.Jennifer C Chapin et al.Journal of the American Chemical Society, 134(36), 15000-15009 (2012-09-04) Purification and characterization of a novel laccase from the mushroom Pleurotus nebrodensis.Guo-Ting Tian et al.Acta biochimica Polonica, 59(3), 407-412 (2012-09-05) Bathochromic and stabilising effects of sugar beet pectin and an isolated pectic fraction on anthocyanins exhibiting pyrogallol and catechol moieties.M Buchweitz et al.Food chemistry, 135(4), 3010-3019 (2012-09-18) Effect of oxaliplatin combined with polyenephosphatidylcholine on the proliferation of human gastric cancer SGC-7901 cellsJiang T, et al. Oncology Letters, 12(6), 4538-4546 (2016) Chemotaxis and degradation of organophosphate compound by a novel moderately thermo-halo tolerant Pseudomonas sp. strain BUR11: evidence for possible existence of two pathways for degradation.Santanu Pailan et al.PeerJ, 3, e1378-e1378 (2015-11-21) Expanding the ChemGPS chemical space with natural products.Josefin Larsson et al.Journal of natural products, 68(7), 985-991 (2005-07-26) Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin.Takeshi Ishii et al.Bioorganic & medicinal chemistry, 18(14), 4892-4896 (2010-07-06) Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice.Intidhar Ben Salem et al.Environmental science and pollution research international, 22(23), 19069-19076 (2015-08-04) Dietary supplementation with cocoa flavanols does not alter colon tissue profiles of native flavanols and their microbial metabolites established during habitual dietary exposure in C57BL/6J mice.Katheryn M Goodrich et al.Journal of agricultural and food chemistry, 62(46), 11190-11199 (2014-10-23) Nafion-mercury coated film electrode for the adsorptive stripping voltammetric determination of lead and cadmium in the presence of pyrogallol red.Edgar Nagles et al.Talanta, 99, 119-124 (2012-09-13) Contact sensitizing potential of pyrogallol and 5-amino-o-cresol in female BALB/c mice.T L Guo et al.Toxicology, 314(2-3), 202-208 (2013-11-01) Crystal structures of dye-decolorizing peroxidase with ascorbic acid and 2,6-dimethoxyphenol.Toru Yoshida et al.FEBS letters, 586(24), 4351-4356 (2012-11-20) Allelopathic mechanism of pyrogallol to Microcystis aeruginosa PCC7806 (Cyanobacteria): from views of gene expression and antioxidant systemShao J, et al. Chemosphere, 75(7), 924-928 (2009) Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.Célia Martins et al.Chemico-biological interactions, 218, 1-9 (2014-05-06) Electrochemical oxidation of pyrogallol: formation and characterization of long-lived oxygen radicals and application to assess the radical scavenging abilities of antioxidants.Shaolin Mu et al.The journal of physical chemistry. B, 116(41), 12567-12573 (2012-09-27) Spectrophotometric determination of sulfide based on peroxidase inhibition by detection of purpurogallin formation.Mohammad Ghadiri et al.Ecotoxicology and environmental safety, 91, 117-121 (2013-02-26) Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study.Cláudia Fetter et al.Frontiers in physiology, 11, 898-898 (2020-09-29) Control of Maillard-type off-flavor development in ultrahigh-temperature-processed bovine milk by phenolic chemistry.Smaro Kokkinidou et al.Journal of agricultural and food chemistry, 62(32), 8023-8033 (2014-07-30) Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects.Michael Murray Journal of toxicology and environmental health. Part B, Critical reviews, 15(6), 365-395 (2012-09-01) In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds.Sevim Beyza Oztürk Sarikaya et al.Bioorganic & medicinal chemistry letters, 21(14), 4259-4262 (2011-06-15) Degradation of anti-inflammatory drug ketoprofen by electro-oxidation: comparison of electro-Fenton and anodic oxidation processes.Ling Feng et al.Environmental science and pollution research international, 21(14), 8406-8416 (2014-04-24) Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate.Tomohiko Tagashira et al.Journal of food science, 77(10), H208-H215 (2012-09-04) Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations.Ghanshyam Upadhyay et al.Chemico-biological interactions, 183(3), 333-340 (2009-12-02) Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations.Ghanshyam Upadhyay et al.Chemico-biological interactions, 183(3), 333-340 (2009-12-02) Molecular Level Insights on Collagen-Polyphenols Interaction Using Spin-Relaxation and Saturation Transfer Difference NMR.R Ravikanth Reddy et al.The journal of physical chemistry. B, 119(44), 14076-14085 (2015-10-09) Versatile peroxidase of Bjerkandera fumosa: substrate and inhibitor specificity.Natalia Pozdnyakova et al.Enzyme and microbial technology, 52(1), 44-53 (2012-12-04) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Yunbao Liu et al.Journal of natural products, 73(7), 1193-1195 (2010-06-23) Identification of protoxins and a microbial basis for red maple (Acer rubrum) toxicosis in equines.Karan Agrawal et al.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 25(1), 112-119 (2012-12-18) Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.Hsien-Tsung Yao et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 120-127 (2014-05-13) Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal modelYang CJ, et al. Lung Cancer, 66(2), 162-168 (2009) Superoxide generated by pyrogallol reduces highly water-soluble tetrazolium salt to produce a soluble formazan: a simple assay for measuring superoxide anion radical scavenging activities of biological and abiological samples.Chen Xu et al.Analytica chimica acta, 793, 53-60 (2013-08-21) Improved covalent immobilization of horseradish peroxidase on macroporous glycidyl methacrylate-based copolymers.Olivera Prodanović et al.Applied biochemistry and biotechnology, 168(5), 1288-1301 (2012-09-04) Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.Haw-Wen Chen et al.Toxicology and applied pharmacology, 280(1), 1-9 (2014-08-12) Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity.Sae-Kwang Ku et al.World journal of gastroenterology, 15(38), 4799-4805 (2009-10-14) Medicinal chemistry as a conduit for the modulation of quorum sensing.Colin A Lowery et al.Journal of medicinal chemistry, 53(21), 7467-7489 (2010-07-31) Attenuated SAG expression exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy of H9c2 cardiomyocytes.J H Park et al.Free radical research, 49(8), 962-972 (2015-04-09) Bioaccumulation and detoxification responses in the scallop Chlamys farreri exposed to tetrabromobisphenol A (TBBPA).Fengxiao Hu et al.Environmental toxicology and pharmacology, 39(3), 997-1007 (2015-04-12) Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.Shohda A El-Maraghy et al.Chemico-biological interactions, 229, 26-35 (2015-02-01) Chromium-Induced Ultrastructural Changes and Oxidative Stress in Roots of Arabidopsis thaliana.Eleftheriou EP, Adamakis ID, Panteris E, et al. International Journal of Molecular Sciences, 16, 15852-15871 (2015) Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin.Shakilur Rahman et al.Evidence-based complementary and alternative medicine : eCAM, 2011, 734785-734785 (2009-10-29) Assessment of endosulfan induced genotoxicity and mutagenicity manifested by oxidative stress pathways in freshwater cyprinid fish crucian carp (Carassius carassius L.).Sabzar Ahmad Dar et al.Chemosphere, 120, 273-283 (2014-08-17) Hormetic effects of noncoplanar PCB exposed to human lung fibroblast cells (HELF) and possible role of oxidative stress.Muhammad Zaffar Hashmi et al.Environmental toxicology, 30(12), 1385-1392 (2014-06-20) Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.Stephen J Glynn et al.Organic & biomolecular chemistry, 13(13), 3887-3899 (2015-02-12) Use of pyrogallol red and pyranine as probes to evaluate antioxidant capacities towards hypochlorite.Fernanda Pérez-Cruz et al.Molecules (Basel, Switzerland), 18(2), 1638-1652 (2013-01-30) Isolation and Characterization of CD271⁺ Stem Cells Derived from Sheep Dermal Skin.Roomina Jahroomishirazi et al.Cells, tissues, organs, 200(2), 141-152 (2015-05-23) RpoS and indole signaling control the virulence of Vibrio anguillarum towards gnotobiotic sea bass (Dicentrarchus labrax) larvae.Xuan Li et al.PloS one, 9(10), e111801-e111801 (2014-11-02) Mitochondrial DNA acquires immunogenicity on exposure to nitrosative stress in patients with vitiligoAl-Shobaili HA and Rasheed Z Human immunology, 75(10), 1053-1061 (2014) Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice.Jayasingh Chellammal Hanish Singh et al.Pharmaceutical biology, 53(5), 630-636 (2014-12-05) Characterization of arsenic-induced cytotoxicity in liver with stress in erythrocytes and its reversibility with Pleurotus florida lectin.Tanmoy Rana et al.Toxicology and industrial health, 31(2), 108-122 (2013-01-04) Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity.Yaqin Xu et al.Food chemistry, 194, 650-658 (2015-10-17) Cymbopogon citratus industrial waste as a potential source of bioactive compounds.Filipa Tavares et al.Journal of the science of food and agriculture, 95(13), 2652-2659 (2014-11-13) Stable, hydroxyl functional polycarbonates with glycerol side chains synthesized from CO(2) and isopropylidene(glyceryl glycidyl ether).Jeannette Geschwind et al.Macromolecular rapid communications, 34(2), 150-155 (2012-11-30) Antioxidant and anti-inflammatory effects of flavocoxid in high-cholesterol-fed rabbits.Ahmed R El-Sheakh et al.Naunyn-Schmiedeberg's archives of pharmacology, 388(12), 1333-1344 (2015-09-06) A novel Ras GTPase (Ras3) regulates conidiation, multi-stress tolerance and virulence by acting upstream of Hog1 signaling pathway in Beauveria bassiana.Yi Guan et al.Fungal genetics and biology : FG & B, 82, 85-94 (2015-07-15) Enhancement on reactive oxygen species and COX-1 mRNA levels modulate the vascular relaxation induced by sodium nitroprusside in denuded mice aorta.Lucas M Kangussu et al.Fundamental & clinical pharmacology, 29(2), 150-163 (2015-01-27) Phosphatidylcholine Supply to Peroxisomes of the Yeast Saccharomyces cerevisiae.Vid V Flis et al.PloS one, 10(8), e0135084-e0135084 (2015-08-05) Altered cytotoxicity of ROS-inducing compounds by sodium pyruvate in cell culture medium depends on the location of ROS generation.Jessica L Kelts et al.SpringerPlus, 4, 269-269 (2015-06-20) Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species.Amanda A Melillo et al.Journal of bacteriology, 191(20), 6447-6456 (2009-08-18) Application of a microplate-based ORAC-pyrogallol red assay for the estimation ofantioxidant capacity: First Action 2012.03.Rocío Ortiz et al.Journal of AOAC International, 95(6), 1558-1561 (2013-03-05) Hydrophilic interaction liquid chromatography method for measuring the composition of aquatic humic substances.Ren-Qi Wang et al.Analytica chimica acta, 853, 608-616 (2014-12-04) Toxicology and carcinogenesis studies of pyrogallol (CAS No. 87-66-1) in F344/N rats and B6C3F1/N mice (dermal studies). National Toxicology Program technical report series, (574)(574), 1-167 (2013-03-23) Effects of 4-hexylresorcinol on the phenoloxidase from Hyphantria cunea (Lepidoptera: Arctiidae): In vivo and in vitro studies.Mahboobeh Sharifi et al.Insect science, 22(5), 639-650 (2014-07-06) Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.Adelaide U P Hain et al.Journal of structural biology, 180(3), 551-562 (2012-09-18) Reactivity of phenolic compounds towards free radicals under in vitro conditions.Sindhu Mathew et al.Journal of food science and technology, 52(9), 5790-5798 (2015-09-08) Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.P C Leal et al.Bioorganic & medicinal chemistry letters, 19(6), 1793-1796 (2009-02-24) Polyphenol content and modulatory activities of some tropical dietary plant extracts on the oxidant activities of neutrophils and myeloperoxidase.Cesar N Tsumbu et al.International journal of molecular sciences, 13(1), 628-650 (2012-02-09) Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?Mattia Gasperotti et al.ACS chemical neuroscience, 6(8), 1341-1352 (2015-04-22) 5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.Saima Salim et al.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 164(2), 117-123 (2012-12-01) Polymer enzyme conjugates as chiral ligands for sharpless dihydroxylation of alkenes in organic solvents.Stefan Konieczny et al.Chembiochem : a European journal of chemical biology, 16(1), 83-90 (2014-11-26) Formation of a dimeric host-guest complex via binding between a dicationic ionic liquid and a pyrogallol[4]arene macrocycle.Drew A Fowler et al.Chemical communications (Cambridge, England), 49(18), 1802-1804 (2013-01-30) Synthesis of diverse analogues of Oenostacin and their antibacterial activities.Vandana Srivastava et al.Bioorganic & medicinal chemistry, 15(1), 518-525 (2006-10-13) Xanthine biosensor based on the direct oxidation of xanthine at an electrogenerated oligomer film.Shaolin Mu et al.Biosensors & bioelectronics, 47, 429-435 (2013-04-25) Biotransformation and nitroglycerin-induced effects on antioxidative defense system in rat erythrocytes and reticulocytes.Snežana D Marković et al.General 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