Melting point	-55 ºC
Water Solubility	Insoluble
Boiling point	154-157 ºC
Flash point	38 ºC
Density	0.858
Refractive index	1.465-1.467

Symbol(GHS)	Xn;N
Hazard Codes	R10;R36/37/38;R51/53;R65
SDS/MSDS	S16;S26;S29;S37/39;S61

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Glucose-induced insulin secretion from islets of fasted rats: modulation by alternate fuel and neurohumoral agonists.W S Zawalich et al.The Journal of endocrinology, 166(1), 111-120 (2000-06-17) Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.P Maechler et al.The Journal of biological chemistry, 274(39), 27905-27913 (1999-09-17) Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells.S F Picton et al.International journal of experimental diabetes research, 2(1), 19-27 (2002-10-09) Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate.Caroline Wardrope et al.FEBS letters, 580(6), 1677-1680 (2006-02-25) Total synthesis of the natural succinate derivative of 5-(hydroxymethyl)furfural isolated from the Noni fruit (Morinda citrifolia).Hector Quiroz-Florentino et al.Natural product research, 23(14), 1355-1362 (2009-09-08) Aspartate transport by the Dct system in Rhizobium leguminosarum negatively affects nitrogen-regulated operons.C J Reid et al.Microbiology (Reading, England), 142 ( Pt 9), 2603-2612 (1996-09-01) Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells.Mohammed Bensellam et al.PloS one, 7(1), e29807-e29807 (2012-01-12) Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis.E Gottlieb et al.Cell death and differentiation, 10(6), 709-717 (2003-05-23) Nutritional value of succinic acid monoethyl ester in starvation.L Ladrière et al.Annals of nutrition & metabolism, 41(2), 118-125 (1997-01-01) Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity.Y P Zhou et al.The American journal of physiology, 270(6 Pt 1), E988-E994 (1996-06-01) Production of [3H]choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets.K Capito et al.Journal of molecular endocrinology, 17(2), 101-107 (1996-10-01) Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.Emma Heart et al.The Biochemical journal, 403(1), 197-205 (2006-12-22) Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol.Takehiro Masuda et al.Dental materials journal, 30(5), 664-671 (2011-09-29) Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.S A Hinke et al.British journal of pharmacology, 150(8), 1031-1043 (2007-03-07) Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.Michael J MacDonald American journal of physiology. Endocrinology and metabolism, 283(2), E302-E310 (2002-07-12) A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.A D Lajoix et al.Diabetes, 50(6), 1311-1323 (2001-05-26) Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors.Zrinka Rajić et al.Molecules (Basel, Switzerland), 23(7) (2018-07-18) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.P Maechler et al.The EMBO journal, 16(13), 3833-3841 (1997-07-01) Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.K A Urban et al.Diabetologia, 48(12), 2563-2566 (2005-11-12) Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.Ismail Syed et al.American journal of physiology. Regulatory, integrative and comparative physiology, 300(3), R756-R762 (2011-01-14) Identification of monomenthyl succinate in natural mint extracts by LC-ESI-MS-MS and GC-MS.Christophe Marin et al.Journal of agricultural and food chemistry, 54(13), 4814-4819 (2006-06-22) The effect of succinic acid monomethyl ester (SAM) on the responses of isolated thoracic aorta in streptozotocin-diabetic rats.S Ozyazgan et al.Pharmacological research, 38(1), 73-79 (1998-08-11) Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid.I Valverde et al.Advances in experimental medicine and biology, 426, 231-234 (1997-01-01) Insulinotropic action of the monoethyl ester of succinic acid.L Ladrière et al.General pharmacology, 31(3), 377-383 (1998-08-14) Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.Emma Heart et al.American journal of physiology. Endocrinology and metabolism, 296(6), E1354-E1362 (2009-03-19) Nitric oxide donors decrease the function and survival of human pancreatic islets.D L Eizirik et al.Molecular and cellular endocrinology, 118(1-2), 71-83 (1996-04-19) Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.Isabelle Briaud et al.Diabetes, 51(3), 662-668 (2002-03-02)

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