Melting point	138-141 ºC
Water Solubility	Insoluble

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitinationWang M, et al. Biomedicine and Pharmacotherapy, 109, 2447-2455 (2019) Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells.Hsing-Yu Weng et al.Journal of biomedical science, 19, 86-86 (2012-10-06) Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutansda Silva TM, et al. BMC Complementary and Alternative Medicine, 18(1), 301-301 (2018) DNA fragmentation is not associated with apoptosis in zerumbone-induced HepG2 cells.Behnam Kamalidehghan et al.Iranian biomedical journal, 16(4), 226-226 (2012-11-28) Zerumbone attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury.Deng Wenhong et al.Mediators of inflammation, 2012, 156507-156507 (2012-04-25) Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis.John H Beattie et al.Molecular nutrition & food research, 55 Suppl 2, S203-S213 (2011-10-05) Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.Kohta Ohnishi et al.Biochemical and biophysical research communications, 430(2), 616-622 (2012-12-12) Antiulcer principle from Zingiber montanum.Mohammad Al-Amin et al.Journal of ethnopharmacology, 141(1), 57-60 (2012-03-01) Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse.Bo-Yie Chen et al.Molecular vision, 17, 723-730 (2011-03-23) Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo.Anuradha Sehrawat et al.Breast cancer research and treatment, 136(2), 429-441 (2012-10-12) Cytotoxicity against cholangiocarcinoma cell lines of zerumbone derivatives.Uraiwan Songsiang et al.European journal of medicinal chemistry, 45(9), 3794-3802 (2010-06-15) Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.Fengnian Yu et al.Cellular and molecular life sciences : CMLS, 68(6), 1033-1040 (2010-08-24) Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway.Yi Sun et al.Die Pharmazie, 68(2), 141-145 (2013-03-09) Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).Manal Mohamed Elhassan Taha et al.Chemico-biological interactions, 186(3), 295-305 (2010-05-11) Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).Manal Mohamed Elhassan Taha et al.Chemico-biological interactions, 186(3), 295-305 (2010-05-11) Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway.Yi Sun et al.Die Pharmazie, 68(2), 141-145 (2013-03-09) Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.Jun-Wan Shin et al.Cancer prevention research (Philadelphia, Pa.), 4(6), 860-870 (2011-03-04) Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.Bo-Yie Chen et al.Molecular vision, 17, 854-863 (2011-04-30) Liquid chromatography-tandem mass spectroscopic method for the determination of zerumbone in human plasma and its application to pharmacokinetics.Eltayeb E M Eid et al.Journal of mass spectrometry : JMS, 46(8), 772-781 (2011-08-13) Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways.Enoch Kumar Perimal et al.Basic & clinical pharmacology & toxicology, 108(3), 155-162 (2010-10-20) Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells.Siddig Ibrahim Abdelwahab et al.International immunopharmacology, 12(4), 594-602 (2012-02-15) Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.M R Sulaiman et al.Fitoterapia, 81(7), 855-858 (2010-06-16) Antibacterial and antimutagenic activities of novel zerumbone analogues.S C Santosh Kumar et al.Food chemistry, 141(2), 1097-1103 (2013-06-26) Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.Eric M Sciullo et al.Archives of toxicology, 84(12), 957-966 (2010-09-25) Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance.Seo-Hyun Choi et al.International journal of radiation oncology, biology, physics, 79(4), 1196-1205 (2011-03-01) Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes.Adel S Al-Zubairi et al.Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 707-712 (2010-02-04) Zerumbone, a Tropical Ginger Sesquiterpene of Zingiber officinale Roscoe, Attenuates α-MSH-Induced Melanogenesis in B16F10 Cells.Taek-In Oh et al.International journal of molecular sciences, 19(10) (2018-10-17) Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells.Siddig Ibrahim Abdelwahab et al.Leukemia research, 35(2), 268-271 (2010-08-17) A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet.Sho Okamoto et al.The FEBS journal, 278(16), 2892-2900 (2011-06-15) Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer.Remya Prasannan et al.Biochemical pharmacology, 84(10), 1268-1276 (2012-07-31) Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trialsRahman HS, et al. BioMed Research International, 2014 (2014) Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells.Nipin Sp et al.Cells, 9(2) (2020-01-26) The ethanol extract of Zingiber zerumbet Smith attenuates non-alcoholic fatty liver disease in hamsters fed on high-fat dietChang CJ, et al. Food And Chemical Toxicology, 65, 33-42 (2014)

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