Melting point	48 ºC
Density	0.961

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Effects of 2-amino-1,3,4-thiadiazole on ribonucleotide pools of leukemia L1210 cells.J A Nelson et al.Cancer research, 36(4), 1375-1378 (1976-04-01) Aminothiadiazole (NSC 4728) in patients with advanced carcinoma of the endometrium. A phase II study of the Gynecologic Oncology group.R F Asbury et al.American journal of clinical oncology, 13(1), 39-41 (1990-02-01) Simultaneous determination of ascorbic acid, dopamine, uric acid and xanthine using a nanostructured polymer film modified electrode.Palraj Kalimuthu et al.Talanta, 80(5), 1686-1691 (2010-02-16) Aminothiadiazole in the treatment of advanced leiomyosarcoma of the uterine corpus. A Gynecologic Oncology Group study.R Asbury et al.American journal of clinical oncology, 18(5), 397-399 (1995-10-01) Preparation of starch derivatives bearing urea groups and the evaluation of antioxidant, antifungal, and antibacterial activities.Jingjing Zhang et al.International journal of biological macromolecules, 141, 1271-1279 (2019-09-08) The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells.Małgorzata Juszczak et al.Folia histochemica et cytobiologica, 49(3), 436-444 (2011-11-01) 2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.M Juszczak et al.Bioorganic & medicinal chemistry letters, 22(17), 5466-5469 (2012-08-11) Aminothiadiazole (NSC #4728) in patients with advanced colon cancer. A phase II study of the Eastern Cooperative Oncology Group.R F Asbury et al.American journal of clinical oncology, 10(5), 380-382 (1987-10-01) Phase II study of aminothiadiazole in advanced squamous cell carcinoma of the esophagus.P F Engstrom et al.American journal of clinical oncology, 14(1), 33-35 (1991-02-01) Aminothiadiazole (NSC #4728) in patients with advanced cervical carcinoma. A phase II study of the Gynecologic Oncology Group.R F Asbury et al.American journal of clinical oncology, 10(4), 299-301 (1987-08-01) Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.Jingjing Zhang et al.Carbohydrate polymers, 215, 108-118 (2019-04-15) Aminothiadiazole (NSC 4728) in patients with advanced ovarian carcinoma. A phase II study of the Gynecologic Oncology Group.R F Asbury et al.American journal of clinical oncology, 9(4), 334-336 (1986-08-01) Phase II trial of aminothiadiazole in previously treated and untreated patients with advanced colorectal carcinoma: an Illinois Cancer Council Trial.G Y Locker et al.Cancer treatment reports, 71(6), 649-650 (1987-06-01) Selective determination of homocysteine at physiological pH using nanostructured film of aminothiadiazole modified electrode.Palraj Kalimuthu et al.Bioelectrochemistry (Amsterdam, Netherlands), 79(2), 168-172 (2010-04-23) Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells.Andrea Cuconati et al.PloS one, 8(1), e54595-e54595 (2013-01-29) Spectrophotometric and electrical studies of charge transfer complexes of 2-amino-1,3,4-thiadiazole with pi-acceptors.M Gaber et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 62(1-3), 526-531 (2005-11-01) Probing Aspergillus niger glucose oxidase with pentacyanoferrate(III) aza- and thia-complexes.J Kulys et al.Journal of inorganic biochemistry, 100(10), 1614-1622 (2006-07-18) A phase II trail of aminothiadiazole in patients with mixed mesodermal tumors of the uterine corpus: a Gynecologic Oncology Group study.R Asbury et al.American journal of clinical oncology, 19(4), 400-402 (1996-08-01) IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.K Hatakeyama et al.The Journal of biological chemistry, 267(29), 20734-20739 (1992-10-15) High-dose aminothiadiazole in advanced colorectal cancer. An Illinois Cancer Center phase II trial.G Y Locker et al.Investigational new drugs, 12(4), 299-301 (1994-01-01) Synthesis of C-β-d-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase.Eszter Szennyes et al.Carbohydrate research, 472, 33-41 (2018-11-20) Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.Wojciech Rzeski et al.Bioorganic & medicinal chemistry, 15(9), 3201-3207 (2007-03-14) Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity.K Aruna et al.Polish journal of pharmacology, 56(2), 233-240 (2004-05-25) Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate.Seung-Ju Yang et al.The Journal of organic chemistry, 78(2), 438-444 (2012-12-12) Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.P J Elson et al.Investigational new drugs, 6(2), 97-103 (1988-06-01) Sindbis virus mutants resistant to mycophenolic acid and ribavirin.L M Scheidel et al.Virology, 158(1), 1-7 (1987-05-01) Aminothiadiazole (NSC 4728) in patients with advanced nonsquamous carcinoma of the cervix. A phase II study of the Gynecologic Oncology Group.R F Asbury et al.American journal of clinical oncology, 12(5), 375-377 (1989-10-01) Synthesis and spectroscopic studies of new Schiff bases.Hamid Latif Siddiqui et al.Molecules (Basel, Switzerland), 11(2), 206-211 (2007-10-27) Synthesis and local anesthetic activity of alkylaminoacyl derivatives of 2-amino-1,3,4-thiadiazole.G Mazzone et al.Farmaco (Societa chimica italiana : 1989), 48(9), 1207-1224 (1993-09-01)

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