Melting point	81-84 ºC
Water Solubility	Insoluble
Boiling point	242 ºC
Flash point	127 ºC
Density	1.298

Symbol(GHS)	T;N
Hazard Codes	R23/24/25;R40;R48/20/21/22;R51/5
SDS/MSDS	S28A;S36/37;S45;S61

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.Christophe Simard et al.British journal of pharmacology, 165(7), 2354-2364 (2011-10-22) Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function.Kiril L Hristov et al.American journal of physiology. Cell physiology, 310(7), C600-C611 (2016-01-23) SPE-LC-MS investigations for the isolation and fractionation of acidic oil degradation products.Dieter Schemeth et al.Analytica chimica acta, 1038, 182-190 (2018-10-04) Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells.Mohamed-Yassine Amarouch et al.Neuroscience letters, 541, 105-110 (2013-02-23) Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid-Induced Differentiation in Motor Neuron-Like NSC-34 Cells.Pei-Chun Chen et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(6), 2374-2388 (2018-08-17) Differential Contribution of CaEric C Lin et al.Frontiers in cellular neuroscience, 11, 182-182 (2017-07-18) Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function.Limin Cao et al.Environmental health : a global access science source, 19(1), 75-75 (2020-07-04) Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice.F Aura Kullmann et al.Naunyn-Schmiedeberg's archives of pharmacology, 391(11), 1191-1202 (2018-07-29) Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.Maria Cristina D Picardo et al.PLoS biology, 17(2), e2006094-e2006094 (2019-02-23) The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.Mihwa Lim et al.PloS one, 7(4), e35177-e35177 (2012-04-26) Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death.Alvaro Becerra et al.Cardiovascular research, 91(4), 677-684 (2011-05-14) Synchronous fluorescence determination of urinary 1-hydroxypyrene, beta-naphthol and 9-hydroxyphenanthrene based on the sensitizing effect of beta-cyclodextrin.Hong-Mei Yang et al.Analytica chimica acta, 636(1), 51-57 (2009-02-24) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.T Grand et al.British journal of pharmacology, 153(8), 1697-1705 (2008-02-26) Involvement of transient receptor potential melastatin 4 channels in the resting membrane potential setting and cholinergic contractile responses in mouse detrusor and ileal smooth muscles.Firoj Alom et al.The Journal of veterinary medical science, 81(2), 217-228 (2018-12-07) Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta.Ana Mrejeru et al.The Journal of physiology, 589(Pt 10), 2497-2514 (2011-04-14) Rapid simultaneous analysis of 1-hydroxypyrene, 2-hydroxyfluorene, 9-hydroxyphenanthrene, 1- and 2-naphthol in urine by first derivative synchronous fluorescence spectrometry using Tween-20 as a sensitizer.Rong-Hui Kang et al.Analytica chimica acta, 658(2), 180-186 (2010-01-28) Detection of polycyclic aromatic hydrocarbons (PAHs) in raw menhaden fish oil using fluorescence spectroscopy: Method development.Edwin A Pena et al.Environmental toxicology and chemistry, 34(9), 1946-1958 (2015-04-14) Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle.Albert L Gonzales et al.American journal of physiology. Cell physiology, 299(5), C1195-C1202 (2010-09-10) Oxygen-containing functional groups on single-wall carbon nanotubes: NEXAFS and vibrational spectroscopic studies.A Kuznetsova et al.Journal of the American Chemical Society, 123(43), 10699-10704 (2001-10-25) A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324).Khajamohiddin Syed et al.PloS one, 6(12), e28286-e28286 (2011-12-14) Sorption comparison between phenanthrene and its degradation intermediates, 9,10-phenanthrenequinone and 9-phenanthrol in soils/sediments.Di Xiao et al.Chemosphere, 86(2), 183-189 (2011-11-08) Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with high-resolution time-of-flight mass spectrometry.Jutta Lintelmann et al.Biomedical chromatography : BMC, 32(5), e4183-e4183 (2018-01-10) The TRPM4 channel inhibitor 9-phenanthrol.R Guinamard et al.British journal of pharmacology, 171(7), 1600-1613 (2014-01-18) Determination of PM2.5-bound polyaromatic hydrocarbons and their hydroxylated derivatives by atmospheric pressure gas chromatography-tandem mass spectrometry.Yanhao Zhang et al.Talanta, 195, 757-763 (2019-01-11) A novel analytical methodology for the determination of hydroxy polycyclic aromatic hydrocarbons in breast and cow milk samples.E Martin-Tornero et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1136, 121912-121912 (2019-12-17) 9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech.James D Angstadt et al.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 203(8), 613-633 (2017-05-13) TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles.Yao Li et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(10), 1706-1714 (2014-08-08) Heavy Exposure of Waste Collectors to Polycyclic Aromatic Hydrocarbons in a Poor Rural Area of Middle China.Jianheng Zheng et al.Environmental science & technology, 52(15), 8866-8875 (2018-07-03) Polycyclic Aromatic Acids Are Primary Metabolites of Alkyl-PAHs-A Case Study with Nereis diversicolor.Linus M V Malmquist et al.Environmental science & technology, 49(9), 5713-5721 (2015-04-02) TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions.John Malysz et al.American journal of physiology. Cell physiology, 318(2), C406-C421 (2019-12-19) Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.Stefano Masoli et al.Communications biology, 3(1), 222-222 (2020-05-10) A TRPM4-dependent current in murine renal primary cilia.Richard J Flannery et al.American journal of physiology. Renal physiology, 309(8), F697-F707 (2015-08-21) TRPM4 channel: a new player in urinary bladder smooth muscle function in rats.Amy C Smith et al.American journal of physiology. Renal physiology, 304(7), F918-F929 (2013-01-04) Direct target and non-target analysis of urban aerosol sample extracts using atmospheric pressure photoionisation high-resolution mass spectrometry.Chiara Giorio et al.Chemosphere, 224, 786-795 (2019-03-10) Efficient and Highly Selective Solvent-Free Oxidation of Primary Alcohols to Aldehydes Using Bucky Nanodiamond.Yangming Lin et al.ChemSusChem, 10(17), 3497-3505 (2017-07-01) Critical Components for Spontaneous Activity and Rhythm Generation in Spinal Cord Circuits in Culture.Samuel Buntschu et al.Frontiers in cellular neuroscience, 14, 81-81 (2020-05-16) Facile preparation of a cationic COF functionalized magnetic nanoparticle and its use for the determination of nine hydroxylated polycyclic aromatic hydrocarbons in smokers' urine.Wenfen Zhang et al.The Analyst, 144(19), 5829-5841 (2019-09-03) Bisoprolol, Known to Be a Selective β₁-Receptor Antagonist, Differentially but Directly Suppresses IK(M) and IK(erg) in Pituitary Cells and Hippocampal Neurons.Edmund Cheung So et al.International journal of molecular sciences, 20(3) (2019-02-06) Coupled-column high-performance liquid chromatographic method for the determination of four metabolites of polycyclic aromatic hydrocarbons, 1-, 4- and 9-hydroxyphenanthrene and 1-hydroxypyrene, in urine.J Lintelmann et al.Journal of chromatography. B, Biomedical applications, 660(1), 67-73 (1994-10-03) Direct quantification of monohydroxy-polycyclic aromatic hydrocarbons in synthetic urine samples via solid-phase extraction-room-temperature fluorescence excitation-emission matrix spectroscopy.Keerthika Vatsavai et al.Analytical biochemistry, 376(2), 213-220 (2008-03-25) Assessing hazardous risks of indoor airborne polycyclic aromatic hydrocarbons in the kitchen and its association with lung functions and urinary PAH metabolites in kitchen workers.Amarnath Singh et al.Clinica chimica acta; international journal of clinical chemistry, 452, 204-213 (2015-12-01) Role of endogenous ENaC and TRP channels in the myogenic response of rat posterior cerebral arteries.Eok-Cheon Kim et al.PloS one, 8(12), e84194-e84194 (2014-01-07) Hydrogen Peroxide Gates a Voltage-Dependent Cation Current in Aplysia Neuroendocrine Cells.Alamjeet K Chauhan et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(50), 9900-9913 (2019-11-05) Novel role for the transient potential receptor melastatin 4 channel in guinea pig detrusor smooth muscle physiology.Amy C Smith et al.American journal of physiology. Cell physiology, 304(5), C467-C477 (2013-01-11) High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BKCa-Channel Activity and Inhibits IK(M) or Ih.Te-Ling Lu et al.Biomolecules, 10(2) (2020-01-30) Shear stress induces a longitudinal Ca(2+) wave via autocrine activation of P2Y1 purinergic signalling in rat atrial myocytes.Joon-Chul Kim et al.The Journal of physiology, 593(23), 5091-5109 (2015-09-18) Activation of a CaSusanne Keckeis et al.Experimental eye research, 161, 61-70 (2017-06-13) Application of nano-sized multi-template imprinted polymer for simultaneous extraction of polycyclic aromatic hydrocarbon metabolites in urine samples followed by ultra-high performance liquid chromatographic analysis.Abhishek Chauhan et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 110-118 (2015-02-11) A gold nanoparticle-based colorimetric probe for rapid detection of 1-hydroxypyrene in urine.Yaqi Hu et al.The Analyst, 140(13), 4662-4667 (2015-05-20) Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study.Fang Wang et al.International archives of occupational and environmental health, 93(6), 707-714 (2020-02-16) PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells.Dong Kun Lee et al.Pflugers Archiv : European journal of physiology (2018-06-23) Whole genome expression in peripheral-blood samples of workers professionally exposed to polycyclic aromatic hydrocarbons.Ming-Tsang Wu et al.Chemical research in toxicology, 24(10), 1636-1643 (2011-08-23) Species-specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil.Erin L Pulster et al.Environmental toxicology and chemistry, 36(11), 3168-3176 (2017-06-22) Oxidative stress and respiratory symptoms due to human exposure to polycyclic aromatic hydrocarbons (PAHs) in Kumasi, Ghana.Nesta Bortey-Sam et al.Environmental pollution (Barking, Essex : 1987), 228, 311-320 (2017-05-30) Specific inhibition of cyclic AMP-dependent protein kinase by the antimalarial halofantrine and by related phenanthrenes.B H Wang et al.Biological chemistry Hoppe-Seyler, 375(8), 527-535 (1994-08-01) Rho kinase activity governs arteriolar myogenic depolarization.Yao Li et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(1), 140-152 (2015-12-15) Effect of thallium exposure and its interaction with smoking on lung function decline: A prospective cohort study.Juanxiu Dai et al.Environment international, 127, 181-189 (2019-03-29)

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