Melting point	51-53 ºC
Water Solubility	0.468 g/L (20 ºC)
Boiling point	260 ºC
Flash point	130 ºC
Density	1.233

Symbol(GHS)	Xn
Hazard Codes	R68
SDS/MSDS	S36/37

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Trypanosoma cruzi chemical proteomics using immobilized benznidazole.Andrea Trochine et al.Experimental parasitology, 140, 33-38 (2014-03-19) Short report: Increasing access to treatment for Chagas disease: the case of Morelos, Mexico.Jennifer Manne-Goehler et al.The American journal of tropical medicine and hygiene, 91(6), 1125-1127 (2014-10-01) In vivo susceptibility to benznidazole of Trypanosoma cruzi strains from the western Brazilian Amazon.Ana P M Teston et al.Tropical medicine & international health : TM & IH, 18(1), 85-95 (2012-11-08) Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain.Miriam Navarro et al.The American journal of tropical medicine and hygiene, 87(3), 489-490 (2012-07-25) Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells.Quhuan Li et al.Cancer biology & therapy, 17(12), 1266-1273 (2016-10-28) Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease.Facundo García-Bournissen et al.Archives of disease in childhood, 100(1), 90-94 (2014-09-12) In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by "click" chemistry.Laura Juárez-Chávez et al.Bioorganic chemistry, 86, 452-458 (2019-02-18) Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.M G Alvarez et al.Transactions of the Royal Society of Tropical Medicine and Hygiene, 106(10), 636-638 (2012-08-18) Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.Sabrina Cencig et al.International journal of antimicrobial agents, 40(6), 527-532 (2012-10-16) Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.María-Jesús Pinazo et al.Antimicrobial agents and chemotherapy, 57(1), 390-395 (2012-11-02) Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.Paula F dos Santos et al.Parasites & vectors, 5, 161-161 (2012-08-09) In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII, and TcV.Susana Revollo et al.Pathogens (Basel, Switzerland), 8(4) (2019-10-23) Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial.Otacilio C Moreira et al.Acta tropica, 125(1), 23-31 (2012-09-18) Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi.Romina Manarin et al.Parasitology international, 62(1), 79-81 (2012-09-15) Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites.Guillermo Cruz-Zetina et al.The American journal of tropical medicine and hygiene, 87(4), 671-674 (2012-08-15) Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi.Viviane Rodrigues Esperandim et al.Experimental parasitology, 133(4), 442-446 (2013-01-01) Improved completion rates and characterization of drug reactions with an intensive Chagas disease treatment program in rural Bolivia.Jeffrey A Tornheim et al.PLoS neglected tropical diseases, 7(9), e2407-e2407 (2013-09-27) Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.Sara Braga Honorato et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 118, 389-394 (2013-10-01) Multicenter epidemiological and clinical study on imported Chagas diseases in Alicante, Spain.José M Ramos et al.Pathogens and global health, 106(6), 340-345 (2012-11-28) Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.Ignacio Martínez et al.Vector borne and zoonotic diseases (Larchmont, N.Y.), 13(3), 181-187 (2013-02-21) An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.Andrew A Voak et al.The Journal of biological chemistry, 288(40), 28466-28476 (2013-08-16) Immunosuppression and Chagas disease: a management challenge.María-Jesús Pinazo et al.PLoS neglected tropical diseases, 7(1), e1965-e1965 (2013-01-26) Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.Israel Molina et al.The New England journal of medicine, 370(20), 1899-1908 (2014-05-16) Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study.D E Perez-Mazliah et al.The Journal of antimicrobial chemotherapy, 68(2), 424-437 (2012-10-30) Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Belinda S Hall et al.Antimicrobial agents and chemotherapy, 56(11), 5821-5830 (2012-09-06) [Trypanosoma cruzi strains resistant to benznidazole occurring in Colombia].Ana María Mejía-Jaramillo et al.Biomedica : revista del Instituto Nacional de Salud, 32(2), 196-205 (2012-12-18) Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.Glaucia Vilar-Pereira et al.Brain, behavior, and immunity, 26(7), 1136-1149 (2012-07-31) Advancing the treatment for Chagas' disease.Pedro Albajar-Viñas et al.The New England journal of medicine, 370(20), 1942-1943 (2014-05-16) Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia.Jean-Philippe Chippaux et al.Transactions of the Royal Society of Tropical Medicine and Hygiene, 107(1), 1-7 (2013-01-09) Modulated dissolution rate from the inclusion complex of antichagasic benznidazole and cyclodextrin using hydrophilic polymer.Lívia C L Sá-Barreto et al.Pharmaceutical development and technology, 18(5), 1035-1041 (2011-12-28) Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi.Alejandra B Ciccarelli et al.Antimicrobial agents and chemotherapy, 56(10), 5315-5320 (2012-08-08) Unexpected performance of physical mixtures over solid dispersions on the dissolution behavior of benznidazole from tablets.Darío Leonardi et al.Journal of pharmaceutical sciences, 102(3), 1016-1023 (2013-01-11) Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome.Kosuke Yasukawa et al.The American journal of tropical medicine and hygiene, 91(1), 84-85 (2014-06-04) Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole.Ivo Santana Caldas et al.Tropical medicine & international health : TM & IH, 18(1), 75-84 (2012-10-31) Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.Juan P Rigalli et al.PLoS neglected tropical diseases, 6(12), e1951-e1951 (2012-12-29) Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.Juciane Vaz Rêgo et al.Experimental parasitology, 148, 73-80 (2014-12-03) Congenital Chagas disease reported in United States.Rebecca Voelker JAMA, 308(5), 443-443 (2012-08-02) Interactive medical case. A patient with syncope.Michelle C Fox et al.The New England journal of medicine, 369(7), e9-e9 (2013-08-16) Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole.Juliana Cogo et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(1), 59-66 (2012-10-17) Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi.Matheus Andrade Rajão et al.Environmental and molecular mutagenesis, 55(4), 309-321 (2013-12-19)

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