Melting point	69-75 ºC
Boiling point	354 ºC
Density	1.09

Symbol(GHS)	Xn
Hazard Codes	R20/22;R36/37/38;R42/43
SDS/MSDS	S26;S36/37/39;S45

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.Anna Maria Ferrari et al.European journal of medicinal chemistry, 42(7), 1028-1031 (2007-02-24) 7, 8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of AktNF-kappaB signalingWang Y, et al. Experimental and Therapeutic Medicine, 5(6), 1770-1774 (2013) Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons.Li Yan et al.Neuroscience bulletin, 28(5), 493-498 (2012-09-11) [Studies on the chemical constituents in roots of Daphne odora var. atrocaulis].Wei Zhang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 30(7), 513-515 (2005-07-14) The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo.Q M Wang et al.Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 18(4), 204-206 (2003-02-06) Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neuronsYan L, et al. Experimental and Therapeutic Medicine, 28(5), 493?498-493?498 (2012) Anti-inflammatory and protective properties of daphnetin in endotoxin-induced lung injury.Wen-wen Yu et al.Journal of agricultural and food chemistry, 62(51), 12315-12325 (2014-11-25) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08) Iron chelator daphnetin against Pneumocystis carinii in vitro.Bin Ye et al.Chinese medical journal, 117(11), 1704-1708 (2004-12-01) Comparative study on schizontocidal activity of recrystallized or crude daphnetin against malaria parasites.Qin-Mei Wang et al.Biomedical and environmental sciences : BES, 17(4), 397-401 (2005-03-05) [Intestinal absorption of daphnetin by rats single pass perfusion in situ].Qiu Du et al.Yao xue xue bao = Acta pharmaceutica Sinica, 44(8), 922-926 (2010-01-09) Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity.Fausto Alejandro Jiménez-Orozco et al.European journal of pharmacology, 668(1-2), 35-41 (2011-07-12) A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.Oleg Fedorov et al.Proceedings of the National Academy of Sciences of the United States of America, 104(51), 20523-20528 (2007-12-14) Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.Nanting Ni et al.Bioorganic & medicinal chemistry letters, 18(5), 1567-1572 (2008-02-12) Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase.Gregory J Finn et al.Biochemical pharmacology, 67(9), 1779-1788 (2004-04-15) [Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats].Letian Chen et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(7), 935-938 (2011-07-19) [Biotransformation of daphnetin by suspension transgenic hairy roots of Polygonum multiflorum].Wenjuan Deng et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(3), 351-355 (2011-05-19) The therapeutic effects of daphnetin in collagen-induced arthritis involve its regulation of Th17 cells.Lina Tu et al.International immunopharmacology, 13(4), 417-423 (2012-05-05) Spectrofluorimetric study of the binding of daphnetin to bovine serum albumin.Jiaqin Liu et al.Journal of pharmaceutical and biomedical analysis, 35(3), 671-677 (2004-05-13) In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis.Si-Cheng Liang et al.Journal of pharmaceutical sciences, 104(10), 3557-3564 (2015-06-25) [In vitro effect of daphnetin on cytochrome C oxidase and ribonucleotide reductase of plasmodium falciparum].Fang Huang et al.Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 24(3), 179-182 (2006-11-11) Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro.Ziyi Wen et al.Drug delivery, 16(4), 214-223 (2009-03-13) [Effect of daphnetin on the exo-erythrocytic stage of rodent malaria].Y G Liu et al.Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 19(1), 30-32 (2003-02-08) Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis.Rongfeng Yao et al.European journal of pharmacology, 670(1), 286-294 (2011-09-15) [Effect of daphnetin on SOD activity and DNA synthesis of Plasmodium falciparum in vitro].Ling-yun Mu et al.Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 21(3), 157-159 (2003-11-25) Therapeutic effects of daphnetin on adjuvant-induced arthritic rats.Qin Gao et al.Journal of ethnopharmacology, 120(2), 259-263 (2008-10-07) Thousands of chemical starting points for antimalarial lead identification.Francisco-Javier Gamo et al.Nature, 465(7296), 305-310 (2010-05-21) Expanding the ChemGPS chemical space with natural products.Josefin Larsson et al.Journal of natural products, 68(7), 985-991 (2005-07-26) [Additive therapeutic effect of a combination of artemether and daphnetin against Plasmodium berghei in mice].Jian Guo et al.Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 22(3), 164-166 (2004-12-16) [Analysis of metabolites of daphnetin in the intestinal wall of rats by liquid chromatography and quatrupole-time of flight mass spectrometry].Jin-jun Shan et al.Yao xue xue bao = Acta pharmaceutica Sinica, 46(11), 1366-1369 (2012-01-21) Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin.Si-Cheng Liang et al.Drug metabolism and disposition: the biological fate of chemicals, 38(6), 973-980 (2010-02-24) Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.E B Yang et al.Biochemical and biophysical research communications, 260(3), 682-685 (1999-07-15) In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.Fang Huang et al.Biomedical and environmental sciences : BES, 19(5), 367-370 (2006-12-28) Binding of the bioactive component daphnetin to human serum albumin demonstrated using tryptophan fluorescence quenching.Jiaqin Liu et al.Macromolecular bioscience, 4(5), 520-525 (2004-10-07) Daphnetin methylation stabilizes the activity of phosphoribulokinase in wheat during cold acclimation.Khalil Kane et al.Biochemistry and cell biology = Biochimie et biologie cellulaire, 90(5), 657-666 (2012-07-26) 7, 8-dihydroxycoumarin may promote sciatic nerve regeneration by suppressing NF-kappaB expression in miceDu JS, et al. Molecular Medicine Reports, 8(5), 1525-1530 (2013) Potential utility of daphnetin as a novel treatment for pemphigus vulgaris.A Feily et al.Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 145(4), 557-558 (2010-09-09) Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.Mohamed R Mohamed et al.Environmental toxicology and pharmacology, 38(2), 531-541 (2014-08-30) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Daphnetin: a novel antimalarial agent with in vitro and in vivo activity.Y Z Yang et al.The American journal of tropical medicine and hygiene, 46(1), 15-20 (1992-01-01) Daphnetin prevents chronic unpredictable stress-induced cognitive deficits.Min-Jing Liao et al.Fundamental & clinical pharmacology, 27(5), 510-516 (2012-06-22) Medicinal chemistry as a conduit for the modulation of quorum sensing.Colin A Lowery et al.Journal of medicinal chemistry, 53(21), 7467-7489 (2010-07-31)

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