Melting point	7 ºC
Boiling point	110-112 ºC (20 mmHg)
Flash point	79 ºC
Density	1.427
Refractive index	1.606-1.609

Symbol(GHS)	Xn
Hazard Codes	R22

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling.Bokyung Sung et al.International journal of cancer, 129(9), 2062-2072 (2010-12-21) Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo.Naghma Khan et al.Antioxidants & redox signaling, 16(11), 1195-1204 (2011-11-26) Butein Shows Cytotoxic Effects and Induces Apoptosis in Human Ovarian Cancer Cells.Pei-Yu Yang et al.The American journal of Chinese medicine, 43(4), 769-782 (2015-06-30) Electrochemical oxidation of butein at glassy carbon electrodes.Alvaro Yamil Tesio et al.Bioelectrochemistry (Amsterdam, Netherlands), 91, 62-69 (2013-02-26) Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Lirui Zhang et al.International journal of molecular medicine, 36(4), 957-966 (2015-08-28) Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.Angeline Wei Ling Chua et al.Biochemical pharmacology, 80(10), 1553-1562 (2010-08-12) Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells.N Y Kim et al.Pharmacology & toxicology, 88(5), 261-266 (2001-06-08) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.E Aizu et al.Carcinogenesis, 7(11), 1809-1812 (1986-11-01) Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10.Dae-Geun Song et al.BMB reports, 43(4), 268-272 (2010-04-29) Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.Kyuichi Kawabata et al.Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28) Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation.Dong-Oh Moon et al.Molecular cancer therapeutics, 9(6), 1583-1595 (2010-06-03) Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.Grace Tak Yi Lau et al.European journal of pharmacology, 648(1-3), 24-30 (2010-09-10) Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells.N Y Kim et al.Pharmacology & toxicology, 88(5), 261-266 (2001-06-08) Butein, a specific protein tyrosine kinase inhibitor.E B Yang et al.Biochemical and biophysical research communications, 245(2), 435-438 (1998-05-08) Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells.Ya-Hui Chen et al.Oncology reports, 27(4), 1233-1237 (2012-01-17) Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells.K Iwashita et al.Bioscience, biotechnology, and biochemistry, 64(9), 1813-1820 (2000-10-31) Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.Agnieszka Szuster-Ciesielska et al.Pharmacological reports : PR, 63(5), 1109-1123 (2011-12-20) Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions.Dong-Sung Lee et al.Toxicology in vitro : an international journal published in association with BIBRA, 27(2), 874-881 (2013-01-16) Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway.Zhihua Cui et al.Current eye research, 37(8), 730-739 (2012-05-15) Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy.Sudharsana Sundarrajan et al.Journal of molecular modeling, 21(9), 247-247 (2015-09-02) The Trend-in-trend Research Design for Causal Inference.Xinyao Ji et al.Epidemiology (Cambridge, Mass.), 28(4), 529-536 (2016-10-25) Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.Peramaiyan Rajendran et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 17(6), 1425-1439 (2010-12-07) Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.Zafar Rasheed et al.The Journal of pharmacology and experimental therapeutics, 333(2), 354-363 (2010-02-19) Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation.Gil-Saeng Jeong et al.Biological & pharmaceutical bulletin, 34(1), 97-102 (2011-01-08) Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor.S M Yu et al.European journal of pharmacology, 280(1), 69-77 (1995-06-23) Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress.Ya-Chen Yang et al.Free radical biology & medicine, 51(11), 2073-2081 (2011-10-04) Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway.Xue Bai et al.Oncology reports, 33(6), 3085-3092 (2015-05-13) Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation.Ji Hoon Jang et al.International journal of molecular medicine, 30(6), 1357-1364 (2012-10-16) Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.Tomohiro Nabekura et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 140-145 (2015-03-18) Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma.Anuradha Sehrawat et al.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 36(2), 63-71 (2012-11-29) Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats.Ming Lu et al.Neuroscience letters, 542, 87-91 (2013-03-19) Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus.Karin Schlangen et al.Journal of experimental botany, 61(12), 3451-3459 (2010-06-23) Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells.Mario Cioce et al.Cell cycle (Georgetown, Tex.), 11(1), 132-140 (2011-12-22) [Studies on phenolic compounds from Sophora alopecuroides].Guiyun Wang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(10), 1238-1240 (2009-08-14) Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities.Li-Heng Yang et al.Molecular medicine reports, 6(5), 1126-1132 (2012-08-17) Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells.Dong-Oh Moon et al.Toxicology in vitro : an international journal published in association with BIBRA, 24(7), 1927-1934 (2010-08-11) Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species.Sung-Gook Cho et al.Journal of experimental & clinical cancer research : CR, 33, 51-51 (2014-06-13) Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress.Agnieszka Szuster-Ciesielska et al.Journal of gastroenterology, 48(2), 222-237 (2012-06-23) Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth.Sung Keun Jung et al.Molecular carcinogenesis, 54(4), 322-331 (2014-07-01) Butein induces apoptotic cell death of human cervical cancer cellsYang P Y, et al. Oncology Letters, 16(5), 6615-6623 (2018) Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways.Chia-Yu Ma et al.Journal of agricultural and food chemistry, 59(16), 9032-9038 (2011-07-21)

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