Melting point	166-170 ºC
Water Solubility	practically insoluble

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC): clinical analyses of patients and an HCC rat model.Xing Wang et al.International journal of clinical and experimental pathology, 8(2), 1466-1478 (2015-05-15) Actions of methyl-, propyl- and butylparaben on estrogen receptor-α and -β and the progesterone receptor in MCF-7 cancer cells and non-cancerous MCF-10A cells.Anna Maria Wróbel et al.Toxicology letters, 230(3), 375-381 (2014-08-17) Development of a DNA vaccine for chicken infectious anemia and its immunogenicity studies using high mobility group box 1 protein as a novel immunoadjuvant indicated induction of promising protective immune responses.Pradeep Mahadev Sawant et al.Vaccine, 33(2), 333-340 (2014-12-03) Cosmetics-triggered percutaneous remote control of transgene expression in mice.Hui Wang et al.Nucleic acids research, 43(14), e91-e91 (2015-05-07) Comparison of the pathogenicity of the USDA challenge virus strain to a field strain of infectious laryngotracheitis virus.Danielle M Koski et al.Biologicals : journal of the International Association of Biological Standardization, 43(4), 232-237 (2015-06-09) Improved sensitivity gas chromatography-mass spectrometry determination of parabens in waters using ionic liquids.Juan Ignacio Cacho et al.Talanta, 146, 568-574 (2015-12-24) Upregulation of miR-34a-5p antagonizes AFB1-induced genotoxicity in F344 rat liver.Caixia Liu et al.Toxicon : official journal of the International Society on Toxinology, 106, 46-56 (2015-09-20) Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures.Tilak Khanal et al.Toxicology letters, 213(2), 174-183 (2012-07-21) Cytotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with selected aluminium compounds, parabens or phthalates.J Roszak et al.Journal of hazardous materials, 392, 122442-122442 (2020-03-21) Predictors and variability of urinary paraben concentrations in men and women, including before and during pregnancy.Kristen W Smith et al.Environmental health perspectives, 120(11), 1538-1543 (2012-06-23) FADD is essential for glucose uptake and survival of thymocytes.Xiang-Yu Zhang et al.Biochemical and biophysical research communications, 451(2), 202-207 (2014-08-01) Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006.Antonia M Calafat et al.Environmental health perspectives, 118(5), 679-685 (2010-01-09) Ultra-preconcentration and determination of selected pharmaceutical and personal care products in different water matrices by solid-phase extraction combined with dispersive liquid-liquid microextraction prior to ultra high pressure liquid chromatography tandem mass spectrometry analysis.Rita Celano et al.Journal of chromatography. A, 1355, 26-35 (2014-06-19) Butyl p-hydroxybenzoic acid induces oxidative stress in mice liver--an in vivo study.Komal H Shah et al.Acta poloniae pharmaceutica, 68(6), 875-879 (2011-12-01) Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells.Anna Maria Wróbel et al.Toxicology letters, 238(2), 110-116 (2015-08-09) New method for the determination of parabens and bisphenol A in human milk samples using ultrasound-assisted extraction and clean-up with dispersive sorbents prior to UHPLC-MS/MS analysis.R Rodríguez-Gómez et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 992, 47-55 (2015-05-06) Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection.Wenjun Yan et al.BMC medical genomics, 8, 52-52 (2015-08-19) Simultaneous determination of electroactive and non-electroactive food preservatives by novel capillary electrophoresis with amperometric detection.Weiyu Wang et al.Analytica chimica acta, 678(1), 39-43 (2010-09-28) Cosmetics as a potential source of environmental contamination in the UK.Danelle Dhanirama et al.Environmental technology, 33(13-15), 1597-1608 (2012-09-20) Water-resistant sunscreens for skin protection: an in vivo approach to the two sources of sunscreen failure to maintain UV protection on consumer skin.G Puccetti International journal of cosmetic science, 37(6), 613-619 (2015-05-06) Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.Alfonso Pérez-Garrido et al.Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06) Paraben concentrations found in human body fluids do not exert steroidogenic effects in human granulosa primary cell cultures.Elena Herrera-Cogco et al.Toxicology mechanisms and methods, 30(5), 336-349 (2020-03-14) 3-(4-Butoxycarbonylphenyloxycarbonyl)-xanthen-9-one.Centore, R, et al. Acta Crystallographica Section C, Crystal Structure Communications, 51(6), 1211-1213 (1995) Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice.Hitoki Yamanaka et al.Experimental animals, 64(4), 375-382 (2015-07-03) Estimation of the effects of longitudinal temperature gradients caused by frictional heating on the solute retention using fully porous and superficially porous sub-2μm materials.Szabolcs Fekete et al.Journal of chromatography. A, 1359, 124-130 (2014-07-30) Relating solubility data of parabens in liquid PEG 400 to the behaviour of PEG 4000-parabens solid dispersions.Johan Unga et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 73(2), 260-268 (2009-06-11) Long-term stability, functional competence, and safety of microencapsulated specific pathogen-free neonatal porcine Sertoli cells: a potential product for cell transplant therapy.Giovanni Luca et al.Xenotransplantation, 22(4), 273-283 (2015-07-03) [Butyl-p-hydroxybenzoate stimulates cystic fibrosis transmembrane conductance regulator Cl- transport].Hong Ge et al.Yao xue xue bao = Acta pharmaceutica Sinica, 44(1), 32-37 (2009-04-09) Microbiota and host determinants of behavioural phenotype in maternally separated mice.G De Palma et al.Nature communications, 6, 7735-7735 (2015-07-29) Determination of four paraben-type preservatives and three benzophenone-type ultraviolet light filters in seafoods by LC-QqLIT-MS/MS.Chao Han et al.Food chemistry, 194, 1199-1207 (2015-10-17) Biological responses in rats exposed to mainstream smoke from a heated cigarette compared to a conventional reference cigarette.Hitoshi Fujimoto et al.Inhalation toxicology, 27(4), 224-236 (2015-05-15) Spatial distribution, temporal variation and risks of parabens and their chlorinated derivatives in urban surface water in Beijing, China.Wenhui Li et al.The Science of the total environment, 539, 262-270 (2015-09-13) Preliminary ecological risk assessment of butylparaben and benzylparaben -1. Removal efficiency in wastewater treatment, acute/chronic toxicity for aquatic organisms, and effects on medaka gene expression.Hiroshi Yamamoto et al.Environmental sciences : an international journal of environmental physiology and toxicology, 14 Suppl, 73-87 (2008-07-24) Allospecific CD4(+) T cells retain effector function and are actively regulated by Treg cells in the context of transplantation tolerance.Jian-Guo Chai et al.European journal of immunology, 45(7), 2017-2027 (2015-05-07) Short-term iontophoretic and post-iontophoretic transport of model penetrants across excised human epidermis.Franklin K Akomeah et al.International journal of pharmaceutics, 367(1-2), 162-168 (2008-10-28) Bursin-like peptide (BLP) enhances H9N2 influenza vaccine induced humoral and cell mediated immune responses.Chen Wang et al.Cellular immunology, 292(1-2), 57-64 (2014-10-06) Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.Si Wang et al.Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15) Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools.Wenhui Li et al.Environmental science and pollution research international, 22(22), 17987-17997 (2015-07-15) Photo-degradation of butyl parahydroxybenzoate by using TiO2-supported catalyst.Patrick Atheba et al.Water science and technology : a journal of the International Association on Water Pollution Research, 67(10), 2141-2147 (2013-05-17) Combined effect of silver nanoparticles and aluminium chloride, butylparaben or diethylphthalate on the malignancy of MDA-MB-231 breast cancer cells and tumor-specific immune responses of human macrophages and monocyte-derived dendritic cells.Joanna Roszak et al.Toxicology in vitro : an international journal published in association with BIBRA, 65, 104774-104774 (2020-01-20) p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells.Zeina Dagher et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 4109-4114 (2012-08-25) Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression.C Lutz et al.Clinical and experimental immunology, 181(2), 343-356 (2015-04-08) DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.Long V Nguyen et al.Nature communications, 5, 5871-5871 (2014-12-24) Microbiota regulates type 1 diabetes through Toll-like receptors.Michael P Burrows et al.Proceedings of the National Academy of Sciences of the United States of America, 112(32), 9973-9977 (2015-07-29) Detection and Genetic Characteristics of H9N2 Avian Influenza Viruses from Live Poultry Markets in Hunan Province, China.Yiwei Huang et al.PloS one, 10(11), e0142584-e0142584 (2015-11-12) Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.Akihiro Hagiwara et al.Journal of toxicologic pathology, 28(4), 189-195 (2015-11-06) The consequence of the chemical composition of HPMC in matrix tablets on the release behaviour of model drug substances having different solubility.Anna Viridén et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 99-110 (2010-11-18) Effects of parabens on apoptosis induced by serum-free medium.Mari Egawa et al.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(3), 196-204 (2012-03-02) Construction of a recombinant duck enteritis virus (DEV) expressing hemagglutinin of H5N1 avian influenza virus based on an infectious clone of DEV vaccine strain and evaluation of its efficacy in ducks and chickens.Jichun Wang et al.Virology journal, 12, 126-126 (2015-08-13) Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application.James M Mathews et al.Xenobiotica; the fate of foreign compounds in biological systems, 43(2), 169-181 (2012-07-27) Synthetic approaches to parabens molecularly imprinted polymers and their applications to the solid-phase extraction of river water samples.A Beltran et al.Analytica chimica acta, 677(1), 72-78 (2010-09-21) Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy.Jie Zhao et al.International immunopharmacology, 26(1), 221-228 (2015-04-11) Superbug hideout: finding MRSA in U.S.wastewater treatment plants.Rebecca Kessler Environmental health perspectives, 120(11), A437-A437 (2012-11-03) Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.Jarmila Knitlova et al.PloS one, 9(12), e114374-e114374 (2014-12-09) Development of piperic acid derivatives from Piper nigrum as UV protection agents.Piyapong Choochana et al.Pharmaceutical biology, 53(4), 477-482 (2014-12-05) Characterization of in vitro antifungal activities of small and American cranberry (Vaccinium oxycoccos L. and V. macrocarpon Aiton) and lingonberry (Vaccinium vitis-idaea L.) concentrates in sugar reduced fruit spreads.Ertan Ermis et al.International journal of food microbiology, 204, 111-117 (2015-04-14) Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model.Jiahua Jiang et al.Oncotarget, 6(17), 15639-15651 (2015-04-25) Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus.Darrell R Kapczynski et al.Vaccine, 33(9), 1197-1205 (2015-01-24) Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa.C J Park et al.Andrologia, 44 Suppl 1, 187-193 (2011-05-20) Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.Shigeo Hayashi et al.Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13) Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.Caroline Stremnitzer et al.The Journal of investigative dermatology, 135(7), 1790-1800 (2015-02-24) Parabens determination in cosmetic and personal care products exploiting a multi-syringe chromatographic (MSC) system and chemiluminescent detection.Melisa Rodas et al.Talanta, 143, 254-262 (2015-06-17) LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.Kasper Skov et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 83-88 (2014-12-23) Comparative analysis of pathologic processes developing in mice housed in SPF vs non-SPF conditions and treated with cyclophosphamide and dsDNA preparation.Evgeniya V Dolgova et al.Pathology, research and practice, 211(10), 754-758 (2015-08-22) Marine fish oils are not equivalent with respect to B-cell membrane organization and activation.Eric A Gurzell et al.The Journal of nutritional biochemistry, 26(4), 369-377 (2015-01-27) Gut/brain axis and the microbiota.Emeran A Mayer et al.The Journal of clinical investigation, 125(3), 926-938 (2015-02-18) Production and characterization of active recombinant interleukin-12/eGFP fusion protein in stably-transfected DF1 chicken cells.Hsing Chieh Wu et al.Biotechnology progress, 31(3), 641-649 (2015-01-15) Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities.Katra Kolšek et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(1), 8-15 (2014-09-07) Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice.B M Johnson et al.Clinical and experimental immunology, 181(2), 323-337 (2015-02-24) Pathologic characterization of genotypes XIV and XVII Newcastle disease viruses and efficacy of classical vaccination on specific pathogen-free birds.L Susta et al.Veterinary pathology, 52(1), 120-131 (2014-02-11) Development of a novel thermostable Newcastle disease virus vaccine vector for expression of a heterologous gene.Guoyuan Wen et al.The Journal of general virology, 96(Pt 6), 1219-1228 (2015-01-30) Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.Lei Lu et al.PloS one, 10(4), e0124504-e0124504 (2015-05-01) Estrogenicity of parabens revisited: impact of parabens on early pregnancy and an uterotrophic assay in mice.Jordan Shaw et al.Reproductive toxicology (Elmsford, N.Y.), 28(1), 26-31 (2009-06-06) Gender bias in lupus: does immune response initiated in the gut mucosa have a role?M-C Gaudreau et al.Clinical and experimental immunology, 180(3), 393-407 (2015-01-22) High efficiency polyethylene glycol diacrylate monoliths for reversed-phase capillary liquid chromatography of small molecules.Pankaj Aggarwal et al.Journal of chromatography. A, 1364, 96-106 (2014-09-07) Do parabens have the ability to interfere with steroidogenesis?Camilla Taxvig et al.Toxicological sciences : an official journal of the Society of Toxicology, 106(1), 206-213 (2008-07-24) Glucocorticoid-like activity of propylparaben, butylparaben, diethylhexyl phthalate and tetramethrin mixtures studied in the MDA-kb2 cell line.Ivana Klopčič et al.Toxicology letters, 232(2), 376-383 (2014-12-03) Preliminary ecological risk assessment of butylparaben and benzylparaben -2. Fate and partitioning in aquatic environments.Hiroshi Yamamoto et al.Environmental sciences : an international journal of environmental physiology and toxicology, 14 Suppl, 97-105 (2008-07-24) In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals.Tomomi Hatanaka et al.Pharmaceutical research, 32(12), 3965-3974 (2015-07-22) Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.Thuy T B Vo et al.Reproductive toxicology (Elmsford, N.Y.), 29(3), 306-316 (2010-02-06) High performance liquid chromatography column packings with deliberately broadened particle size distribution: relation between column performance and packing structure.Anuschka Liekens et al.Journal of chromatography. A, 1218(38), 6654-6662 (2011-08-25) Determination and separation of bisphenol A, phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry.Antonis Myridakis et al.Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04) The aqueous photosensitized degradation of butylparaben.Dorota Gryglik et al.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 8(4), 549-555 (2009-04-02) Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.Alexandre Grand-Guillaume Perrenoud et al.Journal of chromatography. A, 1360, 275-287 (2014-08-19) Solubilization of parabens in aqueous Pluronic solutions: investigating the micellar growth and interaction as a function of paraben composition.M Khimani et al.The journal of physical chemistry. B, 116(51), 14943-14950 (2012-12-06) Cell membrane integrity in myotonic dystrophy type 1: implications for therapy.Anchel González-Barriga et al.PloS one, 10(3), e0121556-e0121556 (2015-03-24)

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