Melting point	-76 ºC
Water Solubility	2.5 g/L (20 ºC)
Boiling point	169 ºC
Flash point	50 ºC
Density	0.7894
Refractive index	1.4295-1.4315

Symbol(GHS)	T
Hazard Codes	R10;R21/22;R23;R34
SDS/MSDS	S16;S26;S36/37/39;S45

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

In vitro and in vivo evaluation of novel anticancer agents in triple negative breast cancer models.KiTani Parker Johnson et al.Journal of health care for the poor and underserved, 24(1 Suppl), 104-111 (2013-02-21) Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation.Jie Li et al.Neuroscience letters, 535, 51-56 (2013-01-22) The role of peroxidases on the mode of action of chalcone in Arabidopsis roots.Carla Díaz-Tielas et al.Plant signaling & behavior, 7(10), 1274-1276 (2012-08-17) Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.Xin Jin et al.European journal of medicinal chemistry, 56, 203-209 (2012-09-18) 3,3',4', 5'-Tetramethoxychalcone inhibits human oral cancer cell proliferation and migration via p53-mediated mitochondrial-dependent apoptosis.Cheng-Kuo Lai et al.Anticancer research, 34(4), 1811-1819 (2014-04-03) Enhanced absorption of hydroxysafflor yellow A using a self-double-emulsifying drug delivery system: in vitro and in vivo studies.Liang-Zhong Lv et al.International journal of nanomedicine, 7, 4099-4107 (2012-08-14) Safflor yellow B suppresses angiotensin II-mediated human umbilical vein cell injury via regulation of Bcl-2/p22(phox) expression.Chaoyun Wang et al.Toxicology and applied pharmacology, 273(1), 59-67 (2013-09-03) Thermodynamics, kinetics, and photochromism of oaklins: a recent family of deoxyanthocyanidins.André Sousa et al.The journal of physical chemistry. B, 117(6), 1901-1910 (2013-01-17) NMR solution structure study of the representative component hydroxysafflor yellow A and other quinochalcone C-glycosides from Carthamus tinctorius.Zi-Ming Feng et al.Journal of natural products, 76(2), 270-274 (2013-02-08) Investigations on the physico chemical properties of 4-bromochalcone single crystals for nonlinear optical applications.S Prabu et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 103, 45-52 (2012-12-22) Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells.Christian Limper et al.The Journal of pharmacy and pharmacology, 65(9), 1393-1408 (2013-08-10) In vitro and in vivo evaluation of novel anticancer agents in triple negative breast cancer models.KiTani Parker Johnson et al.Journal of health care for the poor and underserved, 24(1 Suppl), 104-111 (2013-02-21) The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.Ying Pan et al.Molecules (Basel, Switzerland), 18(2), 1693-1703 (2013-01-30) The design and development of imidazothiazole-chalcone derivatives as potential anticancer drugs.Ahmed Kamal et al.Expert opinion on drug discovery, 8(3), 289-304 (2013-01-16) Letter to the Editor on "Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro".Shailendra Kapoor Biochemical and biophysical research communications, 427(2), 438-438 (2012-09-20) Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification.Oliver A Battenberg et al.Molecular bioSystems, 9(3), 343-351 (2013-01-09) Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation.Kewal Kumar et al.Dalton transactions (Cambridge, England : 2003), 42(5), 1492-1500 (2012-10-31) Aspects of the metabolism of the peripheral vasodilator mecinarone (14C-6809 MD) in rat, dog and man.D R Hawkins et al.European journal of drug metabolism and pharmacokinetics, 5(3), 145-152 (1980-01-01) Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.Xiaoyun Shu et al.Molecules (Basel, Switzerland), 17(11), 12925-12937 (2012-11-03) Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.R M Ezzell et al.The Journal of biological chemistry, 263(26), 13303-13309 (1988-09-15) Hydroxysafflor yellow a inhibits lipopolysaccharide-induced inflammatory signal transduction in human alveolar epithelial A549 cells.Lijuan Song et al.Fitoterapia, 84, 107-114 (2012-11-20) Hydroxysafflor yellow A suppresses oleic acid-induced acute lung injury via protein kinase A.Chaoyun Wang et al.Toxicology and applied pharmacology, 272(3), 895-904 (2013-08-13) [HPLC determination of hydroxysafflor yellow A in Mongolian medicine Dedu Honghuaqiwei pill].Chang-Lian Chen et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3673-3675 (2013-03-13) Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives.Monika Stompor et al.Journal of agricultural and food chemistry, 63(30), 6749-6756 (2015-07-16) Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.Thatiana Lopes Biá Ventura et al.Molecules (Basel, Switzerland), 20(5), 8072-8093 (2015-05-08) Effect of TSHAC on human cytochrome P450 activity, and transport mediated by P-glycoprotein.Yelim Im et al.Journal of microbiology and biotechnology, 22(12), 1659-1664 (2012-12-12) Conventional and Microwave assisted Synthesis of 1, 3- Diphenyl -2- Propenone derivatives and Cytotoxic, Anti bacterial activites.Ahmad MR and Bano N. International Journal of ChemTech Research, 3(3), 1470-1478 (2011) Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.Wenshuang Wu et al.Carcinogenesis, 34(7), 1636-1643 (2013-03-09) Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.Keiko K Lee et al.Journal of ethnopharmacology, 145(1), 286-293 (2012-11-21) Synthesis of some quinolinyl chalcone analogues and investigation of their anticancer and synergistic anticancer effect with doxorubicin.Mohamed R E Aly et al.Bioorganicheskaia khimiia, 38(4), 489-495 (2012-11-30) Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation end products in vitro.Zhenzhen Ni et al.Biological & pharmaceutical bulletin, 35(11), 2050-2053 (2012-09-14) Novel cyclopentadienyl tricarbonyl complexes of (99m)Tc mimicking chalcone as potential single-photon emission computed tomography imaging probes for β-amyloid plaques in brain.Zijing Li et al.Journal of medicinal chemistry, 56(2), 471-482 (2012-12-18) Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model.Yau-Hung Chen et al.Molecules (Basel, Switzerland), 18(2), 2052-2060 (2013-02-07) Bifendate-chalcone hybrids: a new class of potential dual inhibitors of P-glycoprotein and breast cancer resistance protein.Xiaoke Gu et al.Biochemical and biophysical research communications, 455(3-4), 318-322 (2014-12-03) Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC-MS.Cristiane B Mattos et al.Journal of pharmaceutical and biomedical analysis, 70, 652-656 (2012-08-14) A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents.Vikas Tyagi et al.Bioorganic & medicinal chemistry letters, 23(1), 291-296 (2012-11-28) Plasma membrane depolarization precedes photosynthesis damage and long-term leaf bleaching in (E)-chalcone-treated Arabidopsis shoots.C Díaz-Tielas et al.Journal of plant physiology, 218, 56-65 (2017-08-05) Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.Jeanne A Geyer et al.Bioorganic & medicinal chemistry letters, 19(7), 1982-1985 (2009-03-03) A biomimetic strategy to access the silybins: total synthesis of (-)-isosilybin A.Benjamin R McDonald et al.Organic letters, 17(1), 98-101 (2014-12-18)

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