Melting point	-70.9 ºC
Water Solubility	practically insoluble
Boiling point	178 ºC
Flash point	70 ºC
Density	0.919
Refractive index	1.496-1.498

Symbol(GHS)	C
Hazard Codes	R20/21/22;R34
SDS/MSDS	S26;S36/37/39;S45

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.Tetsuro Morinaga et al.Microbiology (Reading, England), 156(Pt 5), 1538-1546 (2010-02-06) Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors.J E Shaw et al.ACS chemical neuroscience, 3(3), 167-177 (2012-08-04) A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes.Dohyun Lee et al.Scientific reports, 7(1), 14125-14125 (2017-10-28) Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.Adam Steel et al.Scientific reports, 8(1), 7792-7792 (2018-05-19) A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease.Masaru Yamaoka et al.Microbial cell factories, 10, 69-69 (2011-09-08) An engineered photoswitchable mammalian pyruvate kinase.Stefanie Gehrig et al.The FEBS journal, 284(18), 2955-2980 (2017-07-18) Amyloid-beta fibrillogenesis: structural insight and therapeutic intervention.Kevin A Dasilva et al.Experimental neurology, 223(2), 311-321 (2009-09-12) Monitoring the changes in low molecular weight carbohydrates in cocoa beans during spontaneous fermentation: A chemometric and kinetic approach.Roberto Megias-Perez et al.Food research international (Ottawa, Ont.), 128, 108865-108865 (2020-01-21) Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.Aaron Y Lai et al.Biochimica et biophysica acta, 1822(10), 1629-1637 (2012-07-18) High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey.Josef Pfeuffer et al.Magnetic resonance imaging, 22(10), 1361-1372 (2005-02-15) Sulfonate protecting groups. Improved synthesis of scyllo-inositol and its orthoformate from myo-inositol.Manash P Sarmah et al.Carbohydrate research, 338(9), 999-1001 (2003-04-12) The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice.Annett Boeddrich et al.Cell chemical biology, 26(1), 109-120 (2018-11-26) Verifying the botanical authenticity of commercial tannins through sugars and simple phenols profiles.Mario Malacarne et al.Food chemistry, 206, 274-283 (2016-04-05) Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures.M Nozadze et al.Seizure, 20(2), 173-176 (2010-11-16) Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.Matthew Townsend et al.Annals of neurology, 60(6), 668-676 (2006-12-29) Complex investigation of extraction techniques applied for cyclitols and sugars isolation from different species of Solidago genus.Ileana-Andreea Ratiu et al.Electrophoresis (2018-03-16) Unusual organic osmolytes in deep-sea animals: adaptations to hydrostatic pressure and other perturbants.Paul H Yancey et al.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 133(3), 667-676 (2002-11-22) Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach.Nilufer Rahmioglu et al.Journal of proteome research, 10(6), 2807-2816 (2011-04-16) Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology.Daniela Fenili et al.Journal of molecular medicine (Berlin, Germany), 85(6), 603-611 (2007-02-07) Botanical origin characterisation of tannins using infrared spectroscopy.Mario Malacarne et al.Food chemistry, 267, 204-209 (2018-06-24) Test-retest reproducibility of neurochemical profiles with short-echo, single-voxel MR spectroscopy at 3T and 7T.Melissa Terpstra et al.Magnetic resonance in medicine, 76(4), 1083-1091 (2015-10-27) Polyphosphate kinases modulate Campylobacter jejuni outer membrane constituents and alter its capacity to invade and survive in intestinal epithelial cells in vitro.Ruby Pina-Mimbela et al.Emerging microbes & infections, 4(12), e77-e77 (2015-12-31) Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.Kostas Vekrellis et al.Journal of neurochemistry, 109(5), 1348-1362 (2009-05-30) Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.Yedi Sun et al.Bioorganic & medicinal chemistry, 16(15), 7177-7184 (2008-07-19) A bacterial cell factory converting glucose into scyllo-inositol, a therapeutic agent for Alzheimer's disease.Christophe Michon et al.Communications biology, 3(1), 93-93 (2020-03-04) Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels.Huey-Fen Tzeng et al.Electrophoresis, 28(8), 1221-1228 (2007-03-14) β-Amyloid peptides and amyloid plaques in Alzheimer's disease.Gunnar K Gouras et al.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 12(1), 3-11 (2014-11-06) Orthologous metabonomic qualification of a rodent model combined with magnetic resonance imaging for an integrated evaluation of the toxicity of Hypochoeris radicata.Céline Domange et al.Chemical research in toxicology, 21(11), 2082-2096 (2008-09-12) scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease.Keran Ma et al.Advances in pharmacology (San Diego, Calif.), 64, 177-212 (2012-07-31) Combination therapy in a transgenic model of Alzheimer's disease.Nurgul Aytan et al.Experimental neurology, 250, 228-238 (2013-10-15) Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.Lana G Kaiser et al.NMR in biomedicine, 18(1), 51-55 (2004-10-07) Small molecule beta-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease.Cheryl A Hawkes et al.The European journal of neuroscience, 31(2), 203-213 (2010-01-16) High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism.A Viola et al.Magma (New York, N.Y.), 17(1), 47-61 (2004-09-02) Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models.Ji-Kyung Choi et al.Neuropharmacology, 59(4-5), 353-357 (2010-04-20) Characterization of cyclitol glycosides by gas chromatography coupled to mass spectrometry.L Ruiz-Aceituno et al.Journal of chromatography. A, 1484, 58-64 (2017-01-12) A metabolomics comparison between sheep's and goat's milk.P Caboni et al.Food research international (Ottawa, Ont.), 119, 869-875 (2019-03-20) Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells.Preston J Hill et al.Scientific reports, 7(1), 4761-4761 (2017-07-08) Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase.Yong-Uk Kwon et al.Bioorganic & medicinal chemistry letters, 13(18), 2981-2984 (2003-08-28) Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.Aarti Krishnan et al.Cell host & microbe, 27(2), 290-306 (2020-01-29) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.Sharmistha Sinha et al.ACS chemical neuroscience, 3(6), 451-458 (2012-08-04) A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease.S Salloway et al.Neurology, 77(13), 1253-1262 (2011-09-16) Identification and characterization of a novel (-)-vibo-quercitol 1-dehydrogenase from Burkholderia terrae suitable for production of (-)-vibo-quercitol from 2-deoxy-scyllo-inosose.Nobuya Itoh et al.Applied microbiology and biotechnology, 101(20), 7545-7555 (2017-09-15) In vivo uptake of β-amyloid by non-plaque associated microglia.Cheryl A Hawkes et al.Current Alzheimer research, 9(8), 890-901 (2012-01-26) Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease.H Randall Griffith et al.NMR in biomedicine, 20(8), 709-716 (2007-02-14)

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