Boiling point	156 ºC
Density	0.871

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Source	SDS/MSDS Samples
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Articles

Peer-Reviewed Papers

Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.Thiago Henrique Lugokenski et al.Basic & clinical pharmacology & toxicology, 111(6), 362-370 (2012-06-19) A step toward the reactivation of aged cholinesterases--crystal structure of ligands binding to aged human butyrylcholinesterase.Marielle Wandhammer et al.Chemico-biological interactions, 203(1), 19-23 (2012-08-28) Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion.Eichi Narimatsu et al.The American journal of emergency medicine, 30(6), 901-907 (2011-08-30) Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates.Zhao Wei et al.Bioorganic chemistry, 81, 681-688 (2018-09-29) Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat.Daina N Buzyurova et al.Toxicology, 444, 152578-152578 (2020-09-09) Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.Laxmikant S Deshpande et al.Neurotoxicology, 44, 17-26 (2014-05-03) An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions.Lin-Na Xie et al.Free radical biology & medicine, 130, 1-7 (2018-10-24) A rare case of combined strychnine and propoxur toxicity from a single preparation.Jeena Jacob et al.Clinical toxicology (Philadelphia, Pa.), 50(3), 224-224 (2012-02-18) Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.Laxmikant S Deshpande et al.Toxicological sciences : an official journal of the Society of Toxicology, 116(2), 623-631 (2010-05-26) Interference by pralidoxime (PAM) salts in clinical laboratory tests.Sumika Nagase et al.Clinica chimica acta; international journal of clinical chemistry, 416, 72-79 (2012-12-01) Differentiated NSC-34 cells as an in vitro cell model for VX.Baishali Kanjilal et al.Toxicology mechanisms and methods, 24(7), 488-494 (2014-07-22) In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes.Leonid Gaidukov et al.BMC clinical pharmacology, 9, 18-18 (2009-11-20) Pralidoxime in organophosphorus poisoning.N R Simkhada et al.JNMA; journal of the Nepal Medical Association, 50(180), 300-302 (2011-11-05) Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.C H Chaou et al.Clinical toxicology (Philadelphia, Pa.), 51(5), 402-408 (2013-04-18) A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin.Kevin G McGarry et al.Toxicological sciences : an official journal of the Society of Toxicology, 174(1), 133-146 (2019-12-28) Mechanism of central hypopnoea induced by organic phosphorus poisoning.Kazuhito Nomura et al.Scientific reports, 10(1), 15834-15834 (2020-09-29) A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.Tamara Kranawetvogl et al.Drug testing and analysis, 12(7), 938-947 (2020-04-09) From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.Brad A Hobson et al.Toxicological sciences : an official journal of the Society of Toxicology, 157(2), 342-353 (2017-03-23) Rapid and complete bioavailability of antidotes for organophosphorus nerve agent and cyanide poisoning in minipigs after intraosseous administration.Douglas B Murray et al.Annals of emergency medicine, 60(4), 424-430 (2012-06-29) Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy.Sara Bohnert et al.Toxicology letters, 324, 86-94 (2020-01-20) Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs.Ying Wang et al.Neurotoxicology, 33(2), 169-177 (2012-01-17) Body mass index as a prognostic factor in organophosphate-poisoned patients.Duk Hee Lee et al.The American journal of emergency medicine, 32(7), 693-696 (2014-05-27) An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.Shan Jin et al.Journal of biomolecular screening, 18(1), 108-115 (2012-09-11) Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.Franz Worek et al.Toxicology letters, 231(1), 92-98 (2014-09-23) Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.Julien Renou et al.Chemico-biological interactions, 203(1), 81-84 (2012-11-01) A retrospective analysis of acute organophosphorus poisoning cases admitted to the tertiary care teaching hospital in South India.M Rajesh Kumar et al.Annals of African medicine, 13(2), 71-75 (2014-04-08) Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.Kimberly D Spradling et al.Journal of neuroinflammation, 8, 83-83 (2011-07-23) Comparing Morphological and Molecular Estimates of Species Diversity in the Freshwater Genus Synura (Stramenopiles): A Model for Understanding Diversity of Eukaryotic Microorganisms.Pavel Škaloud et al.Journal of phycology, 56(3), 574-591 (2020-02-18) Effectiveness of fresh frozen plasma as supplementary treatment in organophosphate poisoning.S Pazooki et al.The Medical journal of Malaysia, 66(4), 342-345 (2012-02-04) Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride.Farhat A Khan et al.Life sciences, 89(25-26), 911-917 (2011-10-13) Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase.Zhao Wei et al.Bioorganic & medicinal chemistry, 25(16), 4497-4505 (2017-07-08) Diabetic ketoacidosis: an uncommon manifestation of pesticide poisoning.Krishnan Swaminathan et al.Diabetes care, 36(1), e4-e4 (2012-12-25) Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).Harald John et al.Drug testing and analysis, 4(3-4), 179-193 (2011-09-29) A trivalent approach for determining in vitro toxicology: Examination of oxime K027.Adriana Prado et al.Journal of applied toxicology : JAT, 35(2), 219-227 (2014-05-24) Repeated pulse intramuscular injection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning.Xue Tang et al.The American journal of emergency medicine, 31(6), 946-949 (2013-05-18) The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation.Nikolina Maček Hrvat et al.Toxicology letters, 293, 222-228 (2017-11-29) Case report: an unusual heart rhythm associated with organophosphate poisoning.Enes Elvin Gul et al.Cardiovascular toxicology, 12(3), 263-265 (2012-04-25) Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus.Mary B Dail et al.Toxicological sciences : an official journal of the Society of Toxicology, 169(2), 465-474 (2019-03-06) Amitraz poisoning -- familiar presentation, unfamiliar diagnosis.B Batra et al.Anaesthesia and intensive care, 40(2), 363-364 (2012-03-16) Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.Jay Spampanato et al.Epilepsia, 60(7), 1387-1398 (2019-05-28) Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase.Gabriele Horn et al.Archives of toxicology, 89(3), 405-414 (2014-06-11) Capillary electrophoresis-immobilized enzyme microreactors for acetylcholinesterase assay with surface modification by highly-homogeneous microporous layer.Xin Liu et al.Journal of chromatography. A, 1609, 460454-460454 (2019-08-25) DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression.Rui Guo et al.Nature microbiology, 5(8), 1051-1063 (2020-05-20) Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.Sílvia Sisó et al.Toxicological sciences : an official journal of the Society of Toxicology, 157(2), 330-341 (2017-03-23) Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig.Harald John et al.Drug testing and analysis, 4(3-4), 169-178 (2011-11-22) Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents.Kevin G McGarry et al.Toxicological sciences : an official journal of the Society of Toxicology, 174(1), 124-132 (2019-12-28) Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.Laxmikant S Deshpande et al.Neurotoxicology, 44, 352-357 (2014-08-31) The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning.A Bayir et al.Human & experimental toxicology, 32(1), 45-52 (2012-10-13) The pharmacokinetics of ketamine following intramuscular injection to F344 rats.Benjamin Moeller et al.Drug testing and analysis, 11(1), 68-76 (2018-07-22) Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin.Kimberly D Spradling et al.Journal of neuroinflammation, 8, 84-84 (2011-07-23) Recurrent neonatal organophoshorus poisoning.Yusuf Parvez et al.Indian pediatrics, 49(9), 752-753 (2012-10-02) Whole-heart 3D late gadolinium-enhanced MR imaging: investigation of optimal scan parameters and clinical usefulness.Misako Yorimitsu et al.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 11(1), 9-16 (2012-03-28) The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity.Eduardo A González et al.Archives of toxicology, 94(6), 2149-2162 (2020-04-19) Exploring pralidoxime chloride as a universal electrochemical probe for organophosphorus pesticides detection.Qiqi Zheng et al.Analytica chimica acta, 982, 78-83 (2017-07-25) Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.Michael Winter et al.Toxicology letters, 244, 136-142 (2015-07-27) Phase II study of magnesium sulfate in acute organophosphate pesticide poisoning.A Basher et al.Clinical toxicology (Philadelphia, Pa.), 51(1), 35-40 (2013-01-15) Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality.Tsung-Ming Shih et al.Toxicology mechanisms and methods, 29(5), 322-333 (2018-12-19) Preparing for chemical terrorism: a study of the stability of expired pralidoxime (2-PAM).Robert S Hoffman et al.Disaster medicine and public health preparedness, 6(1), 20-25 (2011-11-30) The mechanism and benefit of human butyrylcholinesterase activation by what would otherwise be inhibitors.Jure Stojan Chemico-biological interactions, 308, 350-356 (2019-06-08) [Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase].M A Iudin et al.Eksperimental'naia i klinicheskaia farmakologiia, 76(1), 21-24 (2013-03-07)

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