Melting point	-1 ºC
Water Solubility	miscible
Boiling point	130-133 ºC
Flash point	21.5 ºC
Density	0.844
Refractive index	1.4453-1.4473

Symbol(GHS)	C
Hazard Codes	R10;R22;R34
SDS/MSDS	S16;S23;S25;S36/37/39;S45

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Thymoquinone: A promising anti-cancer drug from natural sourcesGali-Muhtasib H The International Journal of Biochemistry & Cell Biology, 38, 1249-1253 (2006) Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities.Muhammad Jahangir Hossen et al.Scientific reports, 7, 42995-42995 (2017-02-22) Interaction of human telomeric G-quadruplex DNA with thymoquinone: a possible mechanism for thymoquinone anticancer effect.Alaa A Salem et al.Biochimica et biophysica acta, 1850(2), 329-342 (2014-12-03) Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats.Shafeeque Ahmad et al.Food chemistry, 138(2-3), 1116-1124 (2013-02-16) Thymoquinone: Novel gastroprotective mechanisms.Mahmoud-Awny Magdy et al.European journal of pharmacology, 697(1-3), 126-131 (2012-10-12) Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell GrowthAhmad Z PLoS ONE, 10 (2015) The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.Ahmed Ragheb et al.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 20(5), 741-752 (2009-09-09) Thymoquinone: a promising anti-cancer drug from natural sources.Hala Gali-Muhtasib et al.The international journal of biochemistry & cell biology, 38(8), 1249-1253 (2005-11-30) Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.Ajaz Ahmad et al.Natural product communications, 10(8), 1395-1398 (2015-10-06) Evaluation of DNA interaction, genotoxicity and oxidative stress induced by iron oxide nanoparticles both in vitro and in vivo: attenuation by thymoquinone.Mohd Owais Ansari et al.Scientific reports, 9(1), 6912-6912 (2019-05-08) Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and p38.Ming-Cheng Chen et al.Journal of agricultural and food chemistry, 63(5), 1540-1546 (2015-01-23) High-performance liquid chromatography quantification of principal antioxidants in black seed (Nigella sativa L.) phytopharmaceuticals.Ghada M Hadad et al.Journal of AOAC International, 95(4), 1043-1047 (2012-09-14) Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats.Mustafa S Atta et al.Oxidative medicine and cellular longevity, 2018, 7845681-7845681 (2018-12-05) Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study.Sanjar Alam et al.International journal of nanomedicine, 7, 5705-5718 (2012-11-28) Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction.Murat Kapan et al.International journal of surgery (London, England), 10(9), 484-488 (2012-07-04) Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway.Lei Peng et al.Oncology reports, 29(2), 571-578 (2012-12-13) Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer.Fadwa Odeh et al.Drug delivery, 19(8), 371-377 (2012-10-10) Thymoquinone: potential cure for inflammatory disorders and cancer.Chern Chiuh Woo et al.Biochemical pharmacology, 83(4), 443-451 (2011-10-19) Structure-activity relationships and mechanism of action of tetragomycin derivatives as inhibitors of Staphylococcus aureus staphyloxanthin biosynthesis.L M B C Ribeiro et al.Microbial pathogenesis, 144, 104127-104127 (2020-03-15) Thymoquinone: fifty years of success in the battle against cancer models.Regine Schneider-Stock et al.Drug discovery today, 19(1), 18-30 (2013-09-05) Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.Tomohiro Nabekura et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 140-145 (2015-03-18) Quinones derived from plant secondary metabolites as anti-cancer agents.Jin-Jian Lu et al.Anti-cancer agents in medicinal chemistry, 13(3), 456-463 (2012-08-31) Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and beta-elemene.Amr E Edris Current clinical pharmacology, 4(1), 43-46 (2009-01-20) Preparation, characterization and antiproliferative activity of thymoquinone-beta-cyclodextrin self assembling nanoparticles.R Abu-Dahab et al.Die Pharmazie, 68(12), 939-944 (2014-01-10) In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.Ryuichi Fujisaki et al.The Southeast Asian journal of tropical medicine and public health, 43(2), 270-279 (2012-10-23) Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis.Hanene Jrah-Harzallah et al.European journal of cancer (Oxford, England : 1990), 49(5), 1127-1135 (2012-11-08) Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.Ilan Botnick et al.Molecules (Basel, Switzerland), 17(9), 10159-10177 (2012-08-28) Effects of sodium arsenite on the some laboratory signs and therapeutic role of thymoquinone in the rats.S Aras et al.European review for medical and pharmacological sciences, 19(4), 658-663 (2015-03-11) Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.Gang-Gang Mu et al.Digestive diseases and sciences, 60(4), 1067-1080 (2014-10-27) Thymoquinone and proanthocyanidin attenuation of diabetic nephropathy in rats.A A Sayed European review for medical and pharmacological sciences, 16(6), 808-815 (2012-08-24) The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury.Mohammad Akram Randhawa et al.Pakistan journal of pharmaceutical sciences, 26(6), 1215-1219 (2013-11-06) Review on molecular and therapeutic potential of thymoquinone in cancer.Sanjeev Banerjee et al.Nutrition and cancer, 62(7), 938-946 (2010-10-07) NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.Kimberly M Sutton et al.Biochemical and biophysical research communications, 426(3), 421-426 (2012-09-11) Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content.Mobina Alemi et al.AAPS PharmSciTech, 14(1), 160-167 (2012-12-21) Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.Subhasis Das et al.PloS one, 7(10), e46641-e46641 (2012-10-19) Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro.Landa Zeenelabdin Ali Salim et al.PloS one, 9(12), e115340-e115340 (2014-12-23) The effect of thymoquinone treatment on the combined renal and pulmonary toxicity of cisplatin and diesel exhaust particles.Badreldin H Ali et al.Experimental biology and medicine (Maywood, N.J.), 240(12), 1698-1707 (2015-05-01) Attenuation of oxidative stress-induced vascular endothelial dysfunction by thymoquinone.Dina S El-Agamy et al.Experimental biology and medicine (Maywood, N.J.), 237(9), 1032-1038 (2012-08-30) In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives.Inna I Severina et al.FEBS letters, 587(13), 2018-2024 (2013-05-15) Synthesis, anticancer activity, and iron affinity of the Actinoplanes metabolite 7,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione.Sandra Breyer et al.Bioorganic & medicinal chemistry, 19(3), 1264-1267 (2011-01-11) Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.Shashi Rajput et al.Life sciences, 93(21), 783-790 (2013-09-21) Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo.Samir Attoub et al.Fundamental & clinical pharmacology, 27(5), 557-569 (2012-07-14) Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo.Joydeb Kumar Kundu et al.Biochemical and biophysical research communications, 438(4), 721-727 (2013-08-06) Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis.E Öztürk et al.Human & experimental toxicology, 39(10), 1364-1373 (2020-05-13) Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.Abeer ElKhoely et al.Journal of natural medicines, 69(3), 313-323 (2015-03-23) Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth.Zulfiqar Ahmad et al.PloS one, 10(5), e0127802-e0127802 (2015-05-23) The protective role of thymoquinone in the prevention of gentamicin ototoxicity.Mustafa Sagit et al.American journal of otolaryngology, 35(5), 603-609 (2014-08-05) Herbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as Phyto-Nanoemulsions.Z Pinar Gumus et al.Colloids and surfaces. B, Biointerfaces, 133, 73-80 (2015-06-19) Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.Johannes Niebler et al.Phytochemistry, 109, 66-75 (2014-12-04) Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling.Gamal Badr et al.Lipids in health and disease, 12, 37-37 (2013-03-20) Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity.A H Alhebshi et al.Biochemical and biophysical research communications, 433(4), 362-367 (2013-03-30) Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic® nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer.Saurav Bhattacharya et al.Journal of controlled release : official journal of the Controlled Release Society, 322, 357-374 (2020-04-04) PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a.Saurav Bhattacharya et al.Biomaterials, 51, 91-107 (2015-03-17) Thymoquinone induces apoptosis in malignant T-cells via generation of ROS.Eileen Manasse Dergarabetian et al.Frontiers in bioscience (Elite edition), 5, 706-719 (2013-01-02) Thymoquinone inhibits lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells.Yanan Wang et al.International immunopharmacology, 26(1), 169-173 (2015-03-26) Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies.Anjali Singh et al.Colloids and surfaces. B, Biointerfaces, 102, 822-832 (2012-10-30) Mitigation of obesity-promoted diseases by Nigella sativa and thymoquinone.Jairam Vanamala et al.Plant foods for human nutrition (Dordrecht, Netherlands), 67(2), 111-119 (2012-04-06) Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats.Shafeeque Ahmad et al.SpringerPlus, 3, 316-316 (2014-07-18) Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP.Arumugam Paramasivam et al.Toxicology letters, 213(2), 151-159 (2012-06-27) Thymoquinone Selectively Induces Hepatocellular Carcinoma Cell Apoptosis in Synergism With Clinical Therapeutics and Dependence of p53 Status.Shah Jehan et al.Frontiers in pharmacology, 11, 555283-555283 (2020-10-13) Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.Hera Chaudhry et al.BioMed research international, 2015, 708691-708691 (2015-09-09) Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors.Swantje C Duncker et al.PloS one, 7(6), e39841-e39841 (2012-07-07) Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.Israr Ahmad et al.Toxicology and applied pharmacology, 270(1), 70-76 (2013-04-16) Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress.Andleeb Khan et al.Molecular and cellular biochemistry, 369(1-2), 55-65 (2012-07-04) Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus.Ikram Ullah et al.Neuromolecular medicine, 17(1), 35-46 (2014-11-29) Thymoquinone restores radiation-induced TGF-β expression and abrogates EMT in chemoradiotherapy of breast cancer cells.Shashi Rajput et al.Journal of cellular physiology, 230(3), 620-629 (2014-08-29)

Remarks