Melting point	-35 ºC
Water Solubility	8.7 g/L (20 ºC)
Boiling point	81-85 ºC
Flash point	13 ºC
Density	1.253
Refractive index	1.444-1.446

Symbol(GHS)	F;T
Hazard Codes	R11;R22;R36/37/38;R45
SDS/MSDS	S45;S53

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Articles

Peer-Reviewed Papers

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.Shinji Kamisuki et al.Journal of medicinal chemistry, 54(13), 4923-4927 (2011-05-13) Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes.Hanne Roberg-Larsen et al.The Journal of steroid biochemistry and molecular biology, 169, 22-28 (2016-02-16) Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells.Eva Bernhart et al.Biochemical pharmacology, 96(2), 119-130 (2015-05-24) Unusual Behavior of the Bipolar Molecule 25-Hydroxycholesterol at the Air/Water Interface-Langmuir Monolayer Approach Complemented with Theoretical Calculations.Anita Wnętrzak et al.The journal of physical chemistry. B, 124(6), 1104-1114 (2020-01-24) Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity.Xingzhe Ma et al.The Journal of experimental medicine, 215(6), 1555-1569 (2018-05-11) Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17β-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).Daniel L Villeneuve et al.Environmental toxicology and chemistry, 36(1), 231-242 (2016-06-18) Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation.Monica de Gaetano et al.Journal of inflammation (London, England), 12, 15-15 (2015-02-28) Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions.Hang Fu et al.Atherosclerosis, 237(2), 443-452 (2014-12-03) Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.Patrizia Romani et al.Nature cell biology, 21(3), 338-347 (2019-02-06) 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.Akira Koarai et al.Respiratory research, 13, 63-63 (2012-08-02) New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.Vicky Howe et al.Biochimica et biophysica acta, 1862(7), 647-657 (2017-03-28) MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent.Katrine Bjune et al.Atherosclerosis, 276, 28-38 (2018-07-20) 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.David R Bauman et al.Proceedings of the National Academy of Sciences of the United States of America, 106(39), 16764-16769 (2009-10-07) Salmonella Translocated Effectors Recruit OSBP1 to the Phagosome to Promote Vacuolar Membrane Integrity.Anna M Kolodziejek et al.Cell reports, 27(7), 2147-2156 (2019-05-16) Changes in the lipid fraction of king mackerel pan fried in coconut oil and cooked in coconut milk.Giselda Macena Lira et al.Food research international (Ottawa, Ont.), 101, 198-202 (2017-09-25) Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A.Annukka M Kivelä et al.Atherosclerosis, 225(2), 335-340 (2012-10-30) Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis.Marina Parra-Robert et al.Biomolecules, 9(9) (2019-09-01) OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.Wenbin Zhong et al.Experimental cell research, 322(2), 227-235 (2014-01-16) The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.Marc M Schumacher et al.eLife, 4 (2015-03-06) The environmental obesogen bisphenol A increases macrophage self-renewal.Grace Ampem et al.Cell and tissue research, 378(1), 81-96 (2019-04-24) Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.Su-Yang Liu et al.Immunity, 38(1), 92-105 (2013-01-01) Cholesterol metabolism and immunity.Anna Simon The New England journal of medicine, 371(20), 1933-1935 (2014-11-13) Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.Gera Goverse et al.Journal of immunology (Baltimore, Md. : 1950), 198(5), 2172-2181 (2017-01-20) Impact of Air Frying on Cholesterol and Fatty Acids Oxidation in Sardines: Protective Effects of Aromatic Herbs.Fernanda S Ferreira et al.Journal of food science, 82(12), 2823-2831 (2017-11-11) Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.Tian Du et al.Breast cancer research : BCR, 20(1), 106-106 (2018-09-06) PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection.Yongjun Yu et al.PLoS pathogens, 9(4), e1003266-e1003266 (2013-04-18) Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.Andrea Reboldi et al.Science (New York, N.Y.), 345(6197), 679-684 (2014-08-12) Dendrogenin A drives LXR to trigger lethal autophagy in cancers.Gregory Segala et al.Nature communications, 8(1), 1903-1903 (2017-12-05) Effect of triptolide on progesterone production from cultured rat granulosa cells.J Zhang et al.Arzneimittel-Forschung, 62(6), 301-306 (2012-05-18) 25-Hydroxycholesterol promotes migration and invasion of lung adenocarcinoma cells.Li Chen et al.Biochemical and biophysical research communications, 484(4), 857-863 (2017-02-09) Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis.Feng Wang et al.Cardiovascular research, 93(1), 190-199 (2011-10-08) A comparative study of the effects of 7β-hydroxycholesterol, 25-hydroxycholesterol, and cholesterol on the structural and thermal phase behavior of multilamellar dipalmitoylphosphatidylcholine bilayer vesicles.Hiroshi Takahashi et al.Chemistry and physics of lipids, 227, 104872-104872 (2020-01-14) mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci.Ilana Kelsey et al.Scientific reports, 7(1), 16112-16112 (2017-11-25) Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.Tetsuya Kimura et al.Nature communications, 7, 13130-13130 (2016-10-13) 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p.Lishan Zhang et al.Biochemical and biophysical research communications, 485(4), 736-741 (2017-03-05) IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.Fadhil Ahsan et al.Scientific reports, 8(1), 1520-1520 (2018-01-26) Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.Zewen K Tuong et al.Endocrinology, 154(1), 140-149 (2012-12-15) Effects of progesterone and norethindrone on female fathead minnow (Pimephales promelas) steroidogenesis.Lene H Petersen et al.Environmental toxicology and chemistry, 34(2), 379-390 (2014-12-04) Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells.Steve Catarino et al.Acta ophthalmologica, 90(4), e255-e263 (2012-02-09) On the formation and possible biological role of 25-hydroxycholesterol.Ulf Diczfalusy Biochimie, 95(3), 455-460 (2012-06-27) Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.Hisatoshi Sugiura et al.Respirology (Carlton, Vic.), 17(3), 533-540 (2012-02-03) ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling.Samantha A Hutchinson et al.Nutrients, 11(11) (2019-11-07) Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.Ciara M Gallagher et al.eLife, 5 (2016-07-21) Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand.Adriana Carino et al.Pharmacological research, 131, 17-31 (2018-03-14) Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.Elaine M Quinet et al.Journal of lipid research, 45(10), 1929-1942 (2004-08-05) Specific cellular incorporation of a pyrene-labelled cholesterol: lipoprotein-mediated delivery toward ordered intracellular membranes.Gérald Gaibelet et al.PloS one, 10(4), e0121563-e0121563 (2015-04-16) Engagement of cellular cholesterol in the life cycle of classical swine fever virus: its potential as an antiviral target.Shaoxiong Yu et al.The Journal of general virology, 100(2), 156-165 (2018-11-30) Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.Zoltán Pataj et al.Journal of chromatography. A, 1439, 82-88 (2015-11-27) Hydroxycholesterol Levels in the Serum and Cerebrospinal Fluid of Patients with Neuromyelitis Optica Revealed by LC-Ag+CIS/MS/MS and LC-ESI/MS/MS with Picolinic Derivatization: Increased Levels and Association with Disability during Acute Attack.Eunju Cha et al.PloS one, 11(12), e0167819-e0167819 (2016-12-13) Cooking, storage, and reheating effect on the formation of cholesterol oxidation products in processed meat products.Muhammad I Khan et al.Lipids in health and disease, 14, 89-89 (2015-08-12) Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells.Haolin Chen et al.Experimental gerontology, 72, 8-15 (2015-09-04) The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.Daqian Xu et al.Nature, 580(7804), 530-535 (2020-04-24) Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.Panagiotis Papatheodorou et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 4883-4892 (2018-12-29) 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.Alexandra Doms et al.Journal of virology, 92(18) (2018-06-29) 25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes.Brett N Olsen et al.Biophysical journal, 100(4), 948-956 (2011-02-16) CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ.Corina Rosales et al.Atherosclerosis, 239(1), 224-231 (2015-01-27) Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.Cinzia Casella et al.Gynecologic oncology, 135(2), 333-341 (2014-08-20) Natural products reveal cancer cell dependence on oxysterol-binding proteins.Anthony W G Burgett et al.Nature chemical biology, 7(9), 639-647 (2011-08-09) Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins.T Vehus et al.Scientific reports, 6, 37507-37507 (2016-11-30) p38MAPK and Rho-dependent kinase are involved in anoikis induced by anicequol or 25-hydroxycholesterol in DLD-1 colon cancer cells.Arowu R Tanaka et al.Biochemical and biophysical research communications, 430(4), 1240-1245 (2012-12-26) Evidence that the pregnane X and retinoid receptors PXR, RAR and RXR may regulate transcription of the transporter hOCT1 in chronic myeloid leukaemia cells.Gemma Austin et al.European journal of haematology, 94(1), 74-78 (2014-07-22) A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.Alastair G Kerr et al.The Journal of pharmacology and experimental therapeutics, 361(3), 417-428 (2017-04-01) A candidate reference measurement procedure for quantifying serum concentrations of 25-hydroxyvitamin D₃ and 25-hydroxyvitamin D₂ using isotope-dilution liquid chromatography-tandem mass spectrometry.Ekaterina M Mineva et al.Analytical and bioanalytical chemistry, 407(19), 5615-5624 (2015-05-15) 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line.Sabine Waltl et al.Neuroscience letters, 539, 16-21 (2013-01-26) Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.Congcong Shen et al.EBioMedicine, 16, 238-250 (2017-02-06) Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.Ulf Diczfalusy et al.Journal of lipid research, 52(8), 1447-1449 (2011-06-10) On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment.Gerald Eibinger et al.Experimental cell research, 319(12), 1828-1838 (2013-04-02) Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.Massimiliano Ruscica et al.The Journal of biological chemistry, 291(7), 3508-3519 (2015-12-17) An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.Kevin A Robertson et al.PLoS biology, 14(3), e1002364-e1002364 (2016-03-05) Reduced expression of pyruvate kinase in kidney proximal tubule cells is a potential mechanism of pravastatin altered glucose metabolism.Yong Pyo Lee et al.Scientific reports, 9(1), 5318-5318 (2019-03-31) OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.Wenbin Zhong et al.Experimental cell research, 317(16), 2353-2363 (2011-06-15) Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.Peter Blattmann et al.Cell systems, 5(6), 604-619 (2017-12-12) Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.Simone Romano et al.The Journal of steroid biochemistry and molecular biology, 167, 135-143 (2016-11-29) 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cellsKoarai A et al Respiratory Research, 13, doi: 10-doi: 10 (2012) Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.Ikuya Sagimori et al.Bioorganic & medicinal chemistry, 28(3), 115298-115298 (2020-01-07) Stable isotope labeling derivatization coupled with magnetic dispersive solid phase extraction for the determination of hydroxyl-containing cholesterol and metabolites by in vivo microdialysis and ultra-high performance liquid chromatography tandem mass spectrometry.Xin Wang et al.Journal of chromatography. A, 1594, 23-33 (2019-02-25) Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells.V Derangère et al.Cell death and differentiation, 21(12), 1914-1924 (2014-08-16) Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor.Daniel L Villeneuve et al.Environmental health perspectives, 117(4), 624-631 (2009-05-15) Antiviral effect of 25-hydroxycholesterol against porcine reproductive and respiratory syndrome virus in vitro.Hong Dong et al.Antiviral therapy, 23(5), 395-404 (2018-03-22) Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats.Guey-Shyang Hwang et al.Scientific reports, 7(1), 9035-9035 (2017-08-24) Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.Shiro Hiramitsu et al.Frontiers in endocrinology, 9, 470-470 (2018-09-08) Oxidative stability of n-3-enriched chicken patties under different package-atmosphere conditions.Ana Penko et al.Food chemistry, 168, 372-382 (2014-08-31) Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation.Shunlin Ren et al.American journal of physiology. Endocrinology and metabolism, 306(2), E123-E130 (2013-12-05) Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.Shingo Miyata et al.The Journal of biological chemistry, 290(33), 20565-20579 (2015-07-05) 27-Hydroxycholesterol suppresses lipid accumulation by down-regulating lipogenic and adipogenic gene expression in 3T3-L1 cells.Bungo Shirouchi et al.Cytotechnology, 69(3), 485-492 (2016-03-18) Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line.Hee-Kyoung Lim et al.Life sciences, 72(12), 1389-1399 (2003-01-16) Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis.Claudia Tonini et al.International journal of molecular sciences, 21(4) (2020-02-23) Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.Shi-You Jiang et al.PLoS genetics, 15(7), e1008289-e1008289 (2019-07-20) Influence of Cooking, Storage Period, and Re-heating on Production of Cholesterol Oxides in Chicken Meat.Juhui Choe et al.Korean journal for food science of animal resources, 38(3), 433-441 (2018-07-19) Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.Patricia Pereiro et al.Antiviral research, 145, 146-159 (2017-08-10) CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway.Lei Wang et al.Journal of virology, 92(24) (2018-09-28) Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis.Anna-Pia Papageorgiou et al.Cardiovascular research, 107(1), 78-88 (2015-05-23) Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors.Xiaohui Liu et al.Toxicology and applied pharmacology, 377, 114610-114610 (2019-06-14) Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment.Linda Omer et al.Disease models & mechanisms, 13(4) (2020-02-02) Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.Jan Van den Bossche et al.Biochemical and biophysical research communications, 455(3-4), 396-402 (2014-12-03) Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1.Yongjun Yu et al.Journal of virology, 86(6), 2942-2949 (2012-01-20) The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.Esperanza Perucha et al.Nature communications, 10(1), 498-498 (2019-02-01) The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.Norbert Volkmar et al.Journal of cell science, 132(2) (2018-12-24) Cholesterol metabolism regulation mediated by SREBP-2, LXRα and miR-33a in rainbow trout (Oncorhynchus mykiss) both in vivo and in vitro.Tengfei Zhu et al.PloS one, 15(2), e0223813-e0223813 (2020-02-29) Effects of LPA2R, LPA3R, or EP4R agonists on luteal or endometrial function in vivo or in vitro and sirtuin or EP1R, EP2R, EP3R or EP4R agonists on endometrial secretion of PGE and PGFMagen E LaPorte et al.Theriogenology, 95, 8-17 (2017-05-04) Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data.Alzbeta Kloudova-Spalenkova et al.The Journal of steroid biochemistry and molecular biology, 197, 105566-105566 (2019-12-25) Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB.Irving L M H Aye et al.Molecular human reproduction, 18(7), 341-353 (2012-01-13) Antiviral oxysterols are present in human milk at diverse stages of lactation.Andrea Civra et al.The Journal of steroid biochemistry and molecular biology, 193, 105424-105424 (2019-07-16) Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.Wendi Sun et al.Scientific reports, 7(1), 7190-7190 (2017-08-05) Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.Hanna Appelqvist et al.PloS one, 7(11), e50262-e50262 (2012-11-21) Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis.Asako Goto et al.Molecular biology of the cell, 23(18), 3624-3635 (2012-08-10) Modulators of the hedgehog signaling pathway.Philipp Heretsch et al.Bioorganic & medicinal chemistry, 18(18), 6613-6624 (2010-08-17) Cardiomyocyte apoptosis in ischaemia-reperfusion due to the exogenous oxidants at the time of reperfusion.Ana-Maria Rosca et al.Cell biology international, 36(12), 1207-1215 (2012-09-22) Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol.Aditya J Desai et al.Clinical nutrition (Edinburgh, Scotland), 35(6), 1374-1379 (2016-03-27) Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1.Stéphane J H Ricoult et al.Molecular and cellular biology, 36(18), 2384-2395 (2016-06-30) Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.Aditya J Desai et al.American journal of physiology. Gastrointestinal and liver physiology, 309(5), G377-G386 (2015-07-04) Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.Joelle Makoukji et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(26), 9620-9629 (2011-07-01) Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis.Ming-Xia Liu et al.Acta pharmacologica Sinica, 38(5), 660-671 (2017-01-24) Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site.Kenji Ohgane et al.Chemistry & biology, 20(3), 391-402 (2013-03-26) An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.Joseph Longo et al.Molecular metabolism, 25, 119-130 (2019-04-27) ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation.Elizabeth S Gold et al.The Journal of experimental medicine, 209(4), 807-817 (2012-04-05) Flip-flop of steroids in phospholipid bilayers: effects of the chemical structure on transbilayer diffusion.Giulia Parisio et al.Journal of the American Chemical Society, 134(29), 12198-12208 (2012-06-29) Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry.Parthajit Mukherjee et al.Biochimica et biophysica acta. Biomembranes, 1860(11), 2356-2365 (2018-06-08) Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.Jaspreet Sandhu et al.Cell, 175(2), 514-529 (2018-09-18) The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.Steve Poirier et al.The Journal of biological chemistry, 289(27), 18736-18751 (2014-05-24) Identification of novel genes and pathways regulating SREBP transcriptional activity.Sandipan Chatterjee et al.PloS one, 4(4), e5197-e5197 (2009-04-22) Detection of dihydroxycholesterols in human plasma using HPLC-ESI-MS/MS.Ratna Karuna et al.Steroids, 99(Pt B), 131-138 (2015-02-17) Human-specific dual regulations of FXR-activation for reduction of fatty liver using in vitro cell culture model.Teruo Miyazaki et al.Journal of clinical biochemistry and nutrition, 64(2), 112-123 (2019-04-03) The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols.Tingting Wu et al.Journal of pharmacological sciences, 127(3), 251-259 (2015-04-04) Central role of SREBP-2 in the pathogenesis of osteoarthritis.Fotini Kostopoulou et al.PloS one, 7(5), e35753-e35753 (2012-06-05) Cholesterol metabolites alleviate injured liver function and decrease mortality in an LPS-induced mouse model.Yanxia Ning et al.Metabolism: clinical and experimental, 71, 83-93 (2017-05-20) The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.Mathieu Blanc et al.Immunity, 38(1), 106-118 (2013-01-01) Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.Hiroaki Fukumoto et al.The Journal of biological chemistry, 277(50), 48508-48513 (2002-10-18) Normal-phase liquid chromatography-atmospheric-pressure photoionization-mass spectrometry analysis of cholesterol and phytosterol oxidation products.Christian H Grün et al.Journal of chromatography. A, 1439, 74-81 (2016-01-18) COMarko Tarvainen et al.Journal of agricultural and food chemistry, 64(51), 9653-9662 (2016-12-16) Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway.Jing Zhu et al.Chemico-biological interactions, 290, 77-87 (2018-06-01) Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation.E Nishio et al.Biochemical and biophysical research communications, 226(3), 928-934 (1996-09-24) Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.Keisuke Fujiyama et al.Nature plants, 5(6), 589-594 (2019-06-12) 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway.Tomohiro Ichikawa et al.Experimental cell research, 319(8), 1176-1186 (2013-03-15)

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