Melting point	301 ºC
Water Solubility	160 g/100 mL

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems.Andrei I Khlebnikov et al.Bioorganic & medicinal chemistry, 15(4), 1749-1770 (2006-12-15) Anticancer effects of baicalein on hepatocellular carcinoma cells.Yi-Hu Zheng et al.Phytotherapy research : PTR, 28(9), 1342-1348 (2014-03-07) Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells.Patchima Sithisarn et al.Antiviral research, 97(1), 41-48 (2012-10-27) Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model.She-Qing Zhang et al.Journal of neuroscience research, 91(9), 1239-1246 (2013-05-21) Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.Yosuke Nishizaki et al.Bioorganic & medicinal chemistry letters, 19(16), 4706-4710 (2009-07-14) Baicalein Inhibits Amadori-Glycated Albumin-Induced MCP-1 Expression in Retinal Ganglion Cells via a MicroRNA-124-Dependent Mechanism.Ning Dong et al.Investigative ophthalmology & visual science, 56(10), 5844-5853 (2015-09-09) Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology.R J Aitken et al.Biochemical pharmacology, 121, 78-96 (2016-09-24) Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.Xiaoxuan Tian et al.Biological & pharmaceutical bulletin, 39(2), 181-191 (2015-11-20) Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert.Muhammad Munawar Hayat et al.Journal of ethnopharmacology, 156, 347-352 (2014-09-16) Baicalein preconditioning protects cardiomyocytes from ischemia-reperfusion injury via mitochondrial oxidant signaling.Wei-Tien Chang et al.The American journal of Chinese medicine, 41(2), 315-331 (2013-04-04) Baicalein-phospholipid complex: a novel drug delivery technology for phytotherapeutics.Devendra Singh Rawat et al.Current drug discovery technologies, 10(3), 224-232 (2013-02-16) Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Victor Kenyon et al.Journal of medicinal chemistry, 54(15), 5485-5497 (2011-07-12) Effect of the lipoxygenase inhibitor baicalein on bone tissue and bone healing in ovariectomized rats.Dominik Saul et al.Nutrition & metabolism, 16, 4-4 (2019-01-18) Rational design of novel, potent small molecule pan-selectin antagonists.Remo Kranich et al.Journal of medicinal chemistry, 50(6), 1101-1115 (2007-02-17) Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.Manuela Schneider et al.Neoplasia (New York, N.Y.), 12(3), 254-263 (2010-03-18) Gaultheria trichophylla (Royle): a source of minerals and biologically active molecules, its antioxidant and anti-lipoxygenase activities.Fiaz Alam et al.BMC complementary and alternative medicine, 17(1), 3-3 (2017-01-05) 2-Aminoresorcinol is a potent alpha-glucosidase inhibitor.Hong Gao et al.Bioorganic & medicinal chemistry letters, 18(2), 812-815 (2007-11-28) Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug.Wujun Dong et al.International journal of nanomedicine, 15, 5629-5643 (2020-08-18) Characterization of the baicalein-bovine serum albumin complex without or with Cu2+ or Fe3+ by spectroscopic approaches.Daojin Li et al.European journal of medicinal chemistry, 46(2), 588-599 (2011-01-05) Inhibitors of histone demethylases.Brian Lohse et al.Bioorganic & medicinal chemistry, 19(12), 3625-3636 (2011-05-21) Antibacterial synergy between linezolid and baicalein against methicillin-resistant Staphylococcus aureus biofilm in vivo.Tangjuan Liu et al.Microbial pathogenesis, 147, 104411-104411 (2020-08-04) Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.Shingo Arioka et al.Bioorganic & medicinal chemistry, 18(4), 1633-1640 (2010-01-26) Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells.Geun-Soo Park et al.Oncotarget, 6(8), 5749-5759 (2015-02-19) Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes.Wei-Ping Chen et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(1), 325-333 (2015-05-15) 4'-bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophages.Dong Han Kim et al.Bioorganic & medicinal chemistry letters, 22(1), 700-705 (2011-11-22) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.Vasilis P Androutsopoulos et al.Bioorganic & medicinal chemistry, 19(9), 2842-2849 (2011-04-13) QSAR modeling of the interaction of flavonoids with GABA(A) receptor.Pablo R Duchowicz et al.European journal of medicinal chemistry, 43(8), 1593-1602 (2007-12-26) Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives.Chih-Hua Tseng et al.European journal of medicinal chemistry, 44(9), 3621-3626 (2009-04-03) 3-Formylchromones: potential antiinflammatory agents.Khalid M Khan et al.European journal of medicinal chemistry, 45(9), 4058-4064 (2010-06-26) 12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase.Amira Othman et al.PloS one, 8(2), e57254-e57254 (2013-02-26) Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.Yuh-Chiang Shen et al.European journal of pharmacology, 465(1-2), 171-181 (2003-03-26) Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.Noelia López-Gutiérrez et al.Food chemistry, 173, 607-618 (2014-12-04) Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).Miklós Poór et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 998-1005 (2016-10-25) Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription.Sheng-Teng Huang et al.Bioorganic & medicinal chemistry letters, 18(18), 5046-5049 (2008-08-30) Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor.Teresa Tarragó et al.Bioorganic & medicinal chemistry, 16(15), 7516-7524 (2008-07-25) Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in mice.Yi-Kuei Wong et al.Pharmacology, 93(5-6), 278-285 (2014-08-30) Effect of the lipoxygenase-inhibitors baicalein and zileuton on the vertebra in ovariectomized rats.D Saul et al.Bone, 101, 134-144 (2017-04-30) Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer.Graham Donald et al.Current drug targets, 13(14), 1772-1776 (2012-11-13) Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas.Se Gun Kim et al.Journal of natural medicines, 67(2), 390-398 (2012-08-03) Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study.Li Gao et al.Pharmacology, biochemistry, and behavior, 133, 155-163 (2015-04-22) Development and extraction optimization of baicalein and pinostrobin from Scutellaria violacea through response surface methodology.Shankar Subramaniam et al.Pharmacognosy magazine, 11(Suppl 1), S127-S138 (2015-06-26) Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats.Wei-Han Li et al.Apoptosis : an international journal on programmed cell death, 25(5-6), 354-369 (2020-04-28) Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).Gao-Feng Shi et al.Journal of chromatographic science, 53(7), 1140-1146 (2015-01-09) Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats.Jiaqi Zhang et al.European journal of pharmacology, 795, 160-168 (2016-12-17) Baicalein Decreases Hydrogen Peroxide-Induced Damage to NG108-15 Cells via Upregulation of Nrf2.Chao-Hung Yeh et al.Journal of cellular physiology, 230(8), 1840-1851 (2015-01-06) HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis.Lianghua Ding et al.Apoptosis : an international journal on programmed cell death, 19(8), 1269-1280 (2014-05-23) Biotransformation of baicalin to baicalein significantly strengthens the inhibition potential towards UDP-glucuronosyltransferases (UGTs) isoforms.Yanjie Teng et al.Die Pharmazie, 68(9), 763-767 (2013-10-24) Cinnamic acid attenuates quorum sensing associated virulence factors and biofilm formation in Pseudomonas aeruginosa PAO1.Jobina Rajkumari et al.Biotechnology letters, 40(7), 1087-1100 (2018-04-24) A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.Joseph A Lutz et al.Fitoterapia, 98, 11-21 (2014-06-28) Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis.Marta Perro Neves et al.European journal of medicinal chemistry, 46(6), 2562-2574 (2011-04-19) Comparative studies on interactions of baicalein, baicalin and scutellarin with lysozyme.Yun Huang et al.European journal of medicinal chemistry, 46(12), 6039-6045 (2011-11-05) 12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.Tobias Rothe et al.The Journal of clinical investigation, 125(5), 1944-1954 (2015-04-07) PF2405, standardized fraction of Scutellaria baicalensis, ameliorates colitis in vitro and in vivo.Wen-Yi Jiang et al.Archives of pharmacal research, 38(6), 1127-1137 (2015-01-13) In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment.Rosi Bissinger et al.Toxins, 6(9), 2771-2786 (2014-09-23) Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation.B Dinda et al.Journal of ethnopharmacology, 161, 255-278 (2014-12-30) MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage.A-Jin Lee et al.Experimental & molecular medicine, 47, e156-e156 (2015-04-04) Metabolomic fingerprinting of saffron by LC/MS: novel authenticity markers.Miguel Guijarro-Díez et al.Analytical and bioanalytical chemistry, 407(23), 7197-7213 (2015-07-23) Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways.Eun Byul Jung et al.European journal of pharmacology, 730, 116-124 (2014-03-19) Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A.Andreas Körner et al.Nature communications, 10(1), 633-633 (2019-02-09) Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase.J Lövey et al.Cancer letters, 335(2), 495-501 (2013-03-26) Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.Yuh-Chiang Shen et al.European journal of pharmacology, 465(1-2), 171-181 (2003-03-26) Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation.Shin Bi Oh et al.British journal of pharmacology, 168(2), 421-431 (2012-08-16) Dietary supplementation of Scutellaria baicalensis extract during early lactation decreases milk somatic cells and increases whole lactation milk yield in dairy cattle.K E Olagaray et al.PloS one, 14(1), e0210744-e0210744 (2019-01-24) Baicalein Exerts Anticancer Effect in Nasopharyngeal Carcinoma In Vitro and In Vivo.Jiandong Guo et al.Oncology research, 27(5), 601-611 (2019-05-06) Baicalein abrogates reactive oxygen species (ROS)-mediated mitochondrial dysfunction during experimental pulmonary carcinogenesis in vivo.Chandrashekar Naveenkumar et al.Basic & clinical pharmacology & toxicology, 112(4), 270-281 (2012-10-16) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3).Rupinder K Lota et al.Bioorganic & medicinal chemistry letters, 16(17), 4519-4522 (2006-06-27) Metabolic Interaction between Ammonia and Baicalein.Shuwei Zhang et al.Chemical research in toxicology, 33(8), 2181-2188 (2020-07-04) HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis.Lianghua Ding et al.Apoptosis : an international journal on programmed cell death, 19(8), 1269-1280 (2014-05-23) Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model.Hitoshi Ashida et al.Pesticide biochemistry and physiology, 120, 14-20 (2015-05-20) New inhibitors for expression of IgE receptor on human mast cell.Satoru Tamura et al.Bioorganic & medicinal chemistry letters, 20(7), 2299-2302 (2010-03-06) Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.Dragan Amić et al.Bioorganic & medicinal chemistry, 18(1), 28-35 (2009-12-01) In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii.A Goc et al.Journal of applied microbiology, 119(6), 1561-1572 (2015-10-13) In vitro and in vivo antimicrobial efficacy of natural plant-derived compounds against Vibrio cholerae of O1 El Tor Inaba serotype.Hyung-Ip Kim et al.Bioscience, biotechnology, and biochemistry, 79(3), 475-483 (2014-12-18) Novel antiviral activity of baicalein against dengue virus.Keivan Zandi et al.BMC complementary and alternative medicine, 12, 214-214 (2012-11-13) Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase.J Lövey et al.Cancer letters, 335(2), 495-501 (2013-03-26) [In vitro effect of banxiaxiexin-decoction and different combinations on the metabolic activities of baicalin and baicalein in rat liver microsomes].Qiao-Ling Cai et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(8), 1286-1290 (2013-01-17) Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi.Naheed Riaz et al.Phytochemistry, 65(8), 1129-1135 (2004-04-28) Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.Evanthia Nikolopoulou et al.Journal of lipid research, 55(12), 2479-2490 (2014-10-18) Evaluation of baicalein, chitosan and usnic acid effect on Candida parapsilosis and Candida krusei biofilm using a Cellavista device.Eva Kvasnickova et al.Journal of microbiological methods, 118, 106-112 (2015-09-13) Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation.Claire Regazzetti et al.The Journal of investigative dermatology, 135(12), 3096-3104 (2015-08-27) Investigation of the immune effects ofBożena Króliczewska et al.Journal of animal science and biotechnology, 8, 22-22 (2017-03-14) Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-β/Smad2/3 signalling pathway.Y F Zhang et al.The British journal of dermatology, 174(1), 120-130 (2015-08-25) Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock.Tzu-Ling Tseng et al.British journal of pharmacology, 173(7), 1179-1195 (2015-12-24) ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells.Ga Bin Park et al.Molecular and cellular biochemistry, 412(1-2), 247-258 (2015-12-24) Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2 signaling.Jing Zong et al.Journal of cellular biochemistry, 114(5), 1058-1065 (2012-12-12) Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.Emika Ohkoshi et al.International journal of oncology, 50(2), 387-395 (2016-12-31) The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms.Ana Roseli S Ribeiro et al.Chemico-biological interactions, 260, 33-41 (2016-10-27) Baicalein Promotes Angiogenesis and Odontoblastic Differentiation via the BMP and Wnt Pathways in Human Dental Pulp Cells.Sang-Im Lee et al.The American journal of Chinese medicine, 44(7), 1457-1472 (2016-11-05) The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase.Li Li et al.Journal of ethnopharmacology, 143(2), 732-739 (2012-08-14) Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects.Ryoko Takasawa et al.Bioorganic & medicinal chemistry, 16(7), 3969-3975 (2008-02-09) Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease.J Xu et al.Cell death & disease, 4, e569-e569 (2013-04-06) Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production.Zhilin Qi et al.Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(9), 845-855 (2013-06-08) On-line comprehensive two-dimensional HepG2 cell membrane chromatographic analysis system for charactering anti-hepatoma components from rat serum after oral administration of Radix scutellariae: A strategy for rapid screening active compounds in vivo.Dan Jia et al.Journal of pharmaceutical and biomedical analysis, 118, 27-33 (2015-10-30) Biological properties of baicalein in cardiovascular system.Yu Huang et al.Current drug targets. Cardiovascular & haematological disorders, 5(2), 177-184 (2005-04-28) Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.Zaijun Zhang et al.Journal of agricultural and food chemistry, 60(33), 8171-8182 (2012-07-31) Chemical & Pharmaceutical Bulletin, 39, 1051-1051 (1991) Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway.Xi Yan et al.Oncology reports, 33(2), 737-743 (2014-12-17) Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells.Yan Chen et al.Oncotarget, 8(6), 10470-10484 (2017-01-07) Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells.S Chen et al.Biochemical and biophysical research communications, 429(1-2), 117-123 (2012-10-16) Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract.Yuan-Xiong Deng et al.Fitoterapia, 83(8), 1435-1442 (2013-01-23) Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.Dina Morshedi et al.Journal of food science, 80(10), H2336-H2345 (2015-09-10) Baicalein protect pancreatic injury in rats with severe acute pancreatitis by inhibiting pro-inflammatory cytokines expression.Jun Li et al.Biochemical and biophysical research communications, 466(4), 664-669 (2015-09-24) Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).Alejandro Carazo Fernández et al.Toxicology letters, 233(2), 68-77 (2015-01-28) Preparation and evaluation of self-microemulsifying drug delivery system of baicalein.Wenli Liu et al.Fitoterapia, 83(8), 1532-1539 (2012-09-18) An Agent-Based Approach to Dynamically Represent the Pharmacokinetic Properties of Baicalein.Xiao Zhu et al.The AAPS journal, 18(6), 1475-1488 (2016-11-05) Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.Qiuna Zhou et al.International journal of pharmaceutics, 454(1), 125-134 (2013-07-16) Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system.Ki Cheon Kim et al.Cell biology and toxicology, 28(6), 421-433 (2012-09-27) A Combination Therapy with Baicalein and Taxol Promotes Mitochondria-Mediated Cell Apoptosis: Involving in Akt/β-Catenin Signaling Pathway.Qiong Pan et al.DNA and cell biology, 35(11), 646-656 (2016-07-15) Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides.Hyuk Sung Kwon et al.Bioorganic & medicinal chemistry letters, 21(14), 4325-4328 (2011-06-15) Baicalein inhibits HMGB1 release and MMP-2/-9 expression in lipopolysaccharide-induced cardiac hypertrophy.Huai-Min Chen et al.The American journal of Chinese medicine, 42(4), 785-797 (2014-07-10) Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.Sophie S Chen et al.Discovery medicine, 14(78), 327-333 (2012-12-04) Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells.Chong-Zhi Wang et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(1), 63-68 (2009-10-20) Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.T Hari Babu et al.Bioorganic & medicinal chemistry letters, 18(5), 1659-1662 (2008-02-08) Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8.Li Gao et al.ACS chemical neuroscience, 9(7), 1714-1724 (2018-04-19) Baicalein potently inhibits Rho kinase activity and suppresses actin stress fiber formation in angiotensin II-stimulated H9c2 cells.Kwang-Seok Oh et al.Biological & pharmaceutical bulletin, 35(8), 1281-1286 (2012-08-07) Baicalein ameliorates inflammatory-related apoptotic and catabolic phenotypes in human chondrocytes.Xiaodong Zhang et al.International immunopharmacology, 21(2), 301-308 (2014-05-27) Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo.Wonhwa Lee et al.Inflammation, 38(1), 110-125 (2014-09-25) Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.Alex N Bullock et al.Journal of medicinal chemistry, 48(24), 7604-7614 (2005-11-24) Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Li Liu et al.Bioorganic & medicinal chemistry letters, 22(1), 154-163 (2011-12-06) Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms.Qin S, Deng F, Wu W, et al. Archives of Biochemistry and Biophysics, 559, 53-61 (2014) Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening.Hwanho Choi et al.Bioorganic & medicinal chemistry letters, 20(21), 6195-6198 (2010-09-21) Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis.Peidong Chen et al.Journal of ethnopharmacology, 162, 207-214 (2015-01-13) [Neuroprotective effect of baicalein in patients with Parkinson's disease].Xin Yu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(4), 421-425 (2012-06-07) Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats.Amjid Ahad et al.Biochimie, 106, 101-110 (2014-08-26) The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells.Tsz Yan Wong et al.PloS one, 10(8), e0135637-e0135637 (2015-08-25) Evaluation of the antioxidative properties of lipoxygenase inhibitors.Grzegorz A Czapski et al.Pharmacological reports : PR, 64(5), 1179-1188 (2012-12-15) New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.Min Li-Weber Cancer treatment reviews, 35(1), 57-68 (2008-11-14) Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.Hisashi Matsuda et al.Bioorganic & medicinal chemistry, 19(9), 2835-2841 (2011-04-16) Gastroprotective effects of Hwanglyeonhaedok-tang against Helicobacter pylori-induced gastric cell injury.Hee-Seon Park et al.Journal of ethnopharmacology, 216, 239-250 (2018-02-08) Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPPKai-Chih Hung et al.Journal of ethnopharmacology, 194, 522-529 (2016-10-16) Protective effect of baicalein on renal ischemia/reperfusion injury in the rat.Kefei Wu et al.Renal failure, 37(2), 285-291 (2014-12-19) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.Benjamin H Maskrey et al.Journal of inflammation (London, England), 11(1), 33-33 (2014-10-29) Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system.Nina M Høyland-Kroghsbo et al.Proceedings of the National Academy of Sciences of the United States of America, 114(1), 131-135 (2016-11-17) Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies.Haijun Chen et al.Cancer letters, 354(1), 5-11 (2014-08-17) Cytotoxic and antioxidant properties of selected Scutellaria species from the Western Ghats of Peninsular India.S Salini et al.Pharmaceutical biology, 51(2), 152-159 (2012-11-07) Kuijieyuan Decoction Improved Intestinal Barrier Injury of Ulcerative Colitis by Affecting TLR4-Dependent PI3K/AKT/NF-κB Oxidative and Inflammatory Signaling and Gut Microbiota.Baohai Liu et al.Frontiers in pharmacology, 11, 1036-1036 (2020-08-28) 12S-Lipoxygenase is necessary for human vascular smooth 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