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m-Cresol | CAS:108-39-4
m-Cresol
  • Name:m-Cresol
  • CAS:108-39-4
  • Synonyms:3-Methylphenol; 3-Hydroxytoluene; 1-Hydroxy-3-methylbenzene
  • Molecular Formula:C7H8O
  • Molecular Weight:108.14
  • EINESC:203-577-9

Description

Properties

Melting point 8-10 ºC
Water Solubility 20 g/L (20 ºC)
Boiling point 203 ºC
Flash point 86 ºC
Density 1.034
Refractive index 1.539-1.541

Safety

Symbol(GHS) T
Hazard Codes R24/25;R34
SDS/MSDS S36/37/39;S45

SDS

Source SDS/MSDS Samples
没有数据没有数据
Synthetic Route
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Name CAS
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Articles
Peer-Reviewed Papers
Activatable two-photon fluorescence nanoprobe for bioimaging of glutathione in living cells and tissues.Hong-Min Meng et al.Analytical chemistry, 86(24), 12321-12326 (2014-11-18) High-performance liquid chromatography separation of unsaturated organic compounds by a monolithic silica column embedded with silver nanoparticles.Yang Zhu et al.Journal of separation science, 38(16), 2841-2847 (2015-06-23) Microfluidic chip with thermoresponsive boronate affinity for the capture-release of cis-diol biomolecules.Yan Man et al.Journal of separation science, 38(2), 339-345 (2014-11-08) OncomiR detection in circulating body fluids: a PDMS microdevice perspective.Cristina Potrich et al.Lab on a chip, 14(20), 4067-4075 (2014-09-02) Silica nanoparticles: preparation, characterization and in vitro/in vivo biodistribution studies.B I Tamba et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 46-55 (2015-02-15) Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells.Mohammad Yahya Hanafi-Bojd et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 248-258 (2014-12-17) Real-time label-free quantitative fluorescence microscopy-based detection of ATP using a tunable fluorescent nano-aptasensor platform.Sajal Shrivastava et al.Nanoscale, 7(46), 19663-19672 (2015-11-11) Development of genistein-PEGylated silica hybrid nanomaterials with enhanced antioxidant and antiproliferative properties on HT29 human colon cancer cells.Héctor Pool et al.American journal of translational research, 10(8), 2306-2323 (2018-09-14) Enantioseparation characteristics of tadalafil and its intermediate on chitin derived chiral stationary phases.Juan Zhang et al.The Analyst, 140(16), 5593-5600 (2015-06-27) Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes.Jéssica Cristiane Magalhães Ierich et al.Scientific reports, 9(1), 2033-2033 (2019-02-16) Functionalization of mesoporous silica nanoparticles with a cell-penetrating peptide to target mammalian sperm in vitro.Natalia Barkalina et al.Nanomedicine (London, England), 10(10), 1539-1553 (2015-05-27) Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation.San Kyeong et al.PloS one, 10(11), e0143727-e0143727 (2015-11-26) Improvement of the activation of lipase from Candida rugosa following physical and chemical immobilization on modified mesoporous silica.Chunfeng Wang et al.Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11) Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum.Shakiba Shahabi et al.ACS applied materials & interfaces, 7(25), 13821-13833 (2015-06-02) Microfluidic Generation of Porous Particles Encapsulating Spongy Graphene for Oil Absorption.Jie Wang et al.Small (Weinheim an der Bergstrasse, Germany), 11(32), 3890-3895 (2015-05-09) Interface-Dominated Time-Dependent Behavior of Poled Poly(Vinylidene Fluoride-Trifluoroethylene)/Barium Titanate Composites.Sara Dalle Vacche et al.Materials (Basel, Switzerland), 13(1) (2020-01-18) TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length.Zhengyu Ma et al.PloS one, 9(11), e112292-e112292 (2014-11-11) Preparation, characterization and adsorption properties of a novel 3-aminopropyltriethoxysilane functionalized sodium alginate porous membrane adsorbent for Cr(III) ions.Jian Hua Chen et al.Journal of hazardous materials, 248-249, 285-294 (2013-02-13) Adsorption and protection of plasmid DNA on mesoporous silica nanoparticles modified with various amounts of organosilane.Hong Yang et al.Journal of colloid and interface science, 369(1), 317-322 (2012-01-10) Label-Free Electrical Immunosensor for Highly Sensitive and Specific Detection of Microcystin-LR in Water Samples.Feng Tan et al.Environmental science & technology, 49(15), 9256-9263 (2015-06-30) Double-scattering/reflection in a single nanoparticle for intensified ultrasound imaging.Kun Zhang et al.Scientific reports, 5, 8766-8766 (2015-03-06) New insights into the complex architecture of siliceous copepod teeth.Jan Michels et al.Zoology (Jena, Germany), 118(3), 141-146 (2015-01-28) Towards high potential magnetic biocatalysts for on-demand elimination of pharmaceuticals.Vaidyanathan Vinoth Kumar et al.Bioresource technology, 200, 81-89 (2015-10-18) Glutamate detection by amino functionalized tetrahedral amorphous carbon surfaces.Emilia Kaivosoja et al.Talanta, 141, 175-181 (2015-05-13) Stimulation of gene transfection by silicon nanowire arrays modified with polyethylenimine.Jingjing Pan et al.ACS applied materials & interfaces, 6(16), 14391-14398 (2014-07-18) Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.Christopher G England et al.PloS one, 10(6), e0129172-e0129172 (2015-06-06) Fabrication and investigation of gold (III) ion-imprinted functionalized silica particles.Majdah R Alotaibi et al.Journal of molecular recognition : JMR, 33(2), e2813-e2813 (2019-12-10) A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy.Zhengze Yu et al.ACS nano, 9(11), 11064-11074 (2015-10-13) Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers.Hokyung Song et al.Materials science & engineering. C, Materials for biological applications, 48, 663-672 (2015-01-13) Highly specific multiplexed RNA imaging in tissues with split-FISH.Jolene Jie Lin Goh et al.Nature methods, 17(7), 689-693 (2020-06-17) High-performance liquid chromatography separation of unsaturated organic compounds by a monolithic silica column embedded with silver nanoparticles.Yang Zhu et al.Journal of separation science, 38(16), 2841-2847 (2015-06-23) Microfluidic chip with thermoresponsive boronate affinity for the capture-release of cis-diol biomolecules.Yan Man et al.Journal of separation science, 38(2), 339-345 (2014-11-08) OncomiR detection in circulating body fluids: a PDMS microdevice perspective.Cristina Potrich et al.Lab on a chip, 14(20), 4067-4075 (2014-09-02) Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells.Mohammad Yahya Hanafi-Bojd et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 248-258 (2014-12-17) Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids.Longjun Tang et al.Small (Weinheim an der Bergstrasse, Germany), 15(39), e1900950-e1900950 (2019-08-14) Aeromonas salmonicida binds differentially to mucins isolated from skin and intestinal regions of Atlantic salmon in an N-acetylneuraminic acid-dependent manner.János T Padra et al.Infection and immunity, 82(12), 5235-5245 (2014-10-08) Women have more potential to induce browning of perirenal adipose tissue than men.Johanna C van den Beukel et al.Obesity (Silver Spring, Md.), 23(8), 1671-1679 (2015-07-17) Sliding and jumping of single EcoRV restriction enzymes on non-cognate DNA.Isabelle Bonnet et al.Nucleic acids research, 36(12), 4118-4127 (2008-06-12) Natural Halloysites-Based Janus Platelet Surfactants for the Formation of Pickering Emulsion and Enhanced Oil Recovery.Lecheng Zhang et al.Scientific reports, 9(1), 163-163 (2019-01-19) Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy.K Heileman et al.Biomicrofluidics, 9(4), 044125-044125 (2015-09-05) Silica nanoparticles: preparation, characterization and in vitro/in vivo biodistribution studies.B I Tamba et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 46-55 (2015-02-15) Functionalization of mesoporous silica nanoparticles with a cell-penetrating peptide to target mammalian sperm in vitro.Natalia Barkalina et al.Nanomedicine (London, England), 10(10), 1539-1553 (2015-05-27) A cell-ECM screening method to predict breast cancer metastasis.L E Barney et al.Integrative biology : quantitative biosciences from nano to macro, 7(2), 198-212 (2014-12-30) Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers.Hokyung Song et al.Materials science & engineering. C, Materials for biological applications, 48, 663-672 (2015-01-13) Highly specific multiplexed RNA imaging in tissues with split-FISH.Jolene Jie Lin Goh et al.Nature methods, 17(7), 689-693 (2020-06-17) Stimulation of gene transfection by silicon nanowire arrays modified with polyethylenimine.Jingjing Pan et al.ACS applied materials & interfaces, 6(16), 14391-14398 (2014-07-18) Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.Christopher G England et al.PloS one, 10(6), e0129172-e0129172 (2015-06-06) Improvement of the activation of lipase from Candida rugosa following physical and chemical immobilization on modified mesoporous silica.Chunfeng Wang et al.Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11) Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules.Sophia Schmitt et al.ACS nano, 9(4), 4219-4226 (2015-03-25) Fabrication and investigation of gold (III) ion-imprinted functionalized silica particles.Majdah R Alotaibi et al.Journal of molecular recognition : JMR, 33(2), e2813-e2813 (2019-12-10) Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles.Guangsheng Du et al.Pharmaceutical research, 35(10), 189-189 (2018-08-15) Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration.Séverine Hamann et al.PloS one, 4(8), e6616-e6616 (2009-08-13) A device design of an integrated CMOS poly-silicon biosensor-on-chip to enhance performance of biomolecular analytes in serum samples.Yen Pei-Wen et al.Biosensors & bioelectronics, 61, 112-118 (2014-05-28) Oligonucleotide biofunctionalization enhances endothelial progenitor cell adhesion on cobalt/chromium stents.Maria Chiara Barsotti et al.Journal of biomedical materials research. Part A, 103(10), 3284-3292 (2015-03-27) Comparative glycoprofiling of HIV gp120 immunogens by capillary electrophoresis and MALDI mass spectrometry.Miklós Guttman et al.Electrophoresis, 36(11-12), 1305-1313 (2015-03-27) Fabrication of magnetic colloidal bicones and their switchable self-assembly.Shanshan Li et al.Soft matter, 16(34), 8024-8032 (2020-08-14) Changes in the TNF-alpha/IL-10 ratio in hyperglycemia-associated pregnancies.Jusciele B Moreli et al.Diabetes research and clinical practice, 107(3), 362-369 (2015-02-05) Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy.Yuran Huang et al.Molecular pharmaceutics, 11(10), 3386-3394 (2014-05-17) Immobilized purine nucleoside phosphorylase from Aeromonas hydrophila as an on-line enzyme reactor for biocatalytic applications.Enrica Calleri et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 79-86 (2014-01-28) Functionalisation of Detonation Nanodiamond for Monodispersed, Soluble DNA-Nanodiamond Conjugates Using Mixed Silane Bead-Assisted Sonication Disintegration.Robert Edgington et al.Scientific reports, 8(1), 728-728 (2018-01-18) Fluoropolymer-Coated PDMS Microfluidic Devices for Application in Organic Synthesis.Tianjin Yang et al.Chemistry (Weinheim an der Bergstrasse, Germany), 24(46), 12078-12083 (2018-07-06) Morphological effects of mitomycin C on urothelial responses to experimentally-induced urethral stricture in rats.In Youb Chang et al.International journal of urology : official journal of the Japanese Urological Association, 22(7), 702-709 (2015-04-15) Cytotoxicity of curcumin silica nanoparticle complexes conjugated with hyaluronic acid on colon cancer cells.Surya Prakash Singh et al.International journal of biological macromolecules, 74, 162-170 (2014-12-17) Microfluidic Generation of Porous Particles Encapsulating Spongy Graphene for Oil Absorption.Jie Wang et al.Small (Weinheim an der Bergstrasse, Germany), 11(32), 3890-3895 (2015-05-09) Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum.Shakiba Shahabi et al.ACS applied materials & interfaces, 7(25), 13821-13833 (2015-06-02) Interface-Dominated Time-Dependent Behavior of Poled Poly(Vinylidene Fluoride-Trifluoroethylene)/Barium Titanate Composites.Sara Dalle Vacche et al.Materials (Basel, Switzerland), 13(1) (2020-01-18) Preparation, characterization and adsorption properties of a novel 3-aminopropyltriethoxysilane functionalized sodium alginate porous membrane adsorbent for Cr(III) ions.Jian Hua Chen et al.Journal of hazardous materials, 248-249, 285-294 (2013-02-13) Adsorption and protection of plasmid DNA on mesoporous silica nanoparticles modified with various amounts of organosilane.Hong Yang et al.Journal of colloid and interface science, 369(1), 317-322 (2012-01-10) TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length.Zhengyu Ma et al.PloS one, 9(11), e112292-e112292 (2014-11-11) Effect of divalent versus monovalent cations on the MS2 retention capacity of amino-functionalized ceramic filters.Bartels J, et al. Physical Chemistry Chemical Physics, 20(16), 11215-11223 (2018) Label-Free Electrical Immunosensor for Highly Sensitive and Specific Detection of Microcystin-LR in Water Samples.Feng Tan et al.Environmental science & technology, 49(15), 9256-9263 (2015-06-30) Effect of surface functionality of silica nanoparticles on cellular uptake and cytotoxicity.Siddharth Jambhrunkar et al.Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29) Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation.San Kyeong et al.PloS one, 10(11), e0143727-e0143727 (2015-11-26) Enantioseparation characteristics of tadalafil and its intermediate on chitin derived chiral stationary phases.Juan Zhang et al.The Analyst, 140(16), 5593-5600 (2015-06-27) Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes.Jéssica Cristiane Magalhães Ierich et al.Scientific reports, 9(1), 2033-2033 (2019-02-16) A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy.Zhengze Yu et al.ACS nano, 9(11), 11064-11074 (2015-10-13) Double-scattering/reflection in a single nanoparticle for intensified ultrasound imaging.Kun Zhang et al.Scientific reports, 5, 8766-8766 (2015-03-06) Towards high potential magnetic biocatalysts for on-demand elimination of pharmaceuticals.Vaidyanathan Vinoth Kumar et al.Bioresource technology, 200, 81-89 (2015-10-18) Glutamate detection by amino functionalized tetrahedral amorphous carbon surfaces.Emilia Kaivosoja et al.Talanta, 141, 175-181 (2015-05-13) Development of genistein-PEGylated silica hybrid nanomaterials with enhanced antioxidant and antiproliferative properties on HT29 human colon cancer cells.Héctor Pool et al.American journal of translational research, 10(8), 2306-2323 (2018-09-14) New insights into the complex architecture of siliceous copepod teeth.Jan Michels et al.Zoology (Jena, Germany), 118(3), 141-146 (2015-01-28) Ultrathin, ultrasmooth gold layer on dielectrics without the use of additional metallic adhesion layers.Lorenzo Leandro et al.ACS applied materials & interfaces, 7(10), 5797-5802 (2015-02-28) Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes.S R Simon Ting et al.Biomaterials, 34(17), 4377-4386 (2013-03-13) Disclosing caffeine action on insulin sensitivity: effects on rat skeletal muscle.Joana F Sacramento et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 107-116 (2015-02-11) Cellular Responses Modulated by FGF-2 Adsorbed on Albumin/Heparin Layer-by-Layer Assemblies.Marta Kumorek et al.PloS one, 10(5), e0125484-e0125484 (2015-05-07) Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts.Luciana Armada et al.Journal of endodontics, 41(8), 1281-1287 (2015-05-10) Mesoporous Silica Nanoparticles Decorated with Carbosilane Dendrons as New Non-viral Oligonucleotide Delivery Carriers.Ángel Martínez et al.Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15651-15666 (2015-09-12) Effective removal of heavy metal ions Cd2+, Zn2+, Pb2+, Cu2+ from aqueous solution by polymer-modified magnetic nanoparticles.Fei Ge et al.Journal of hazardous materials, 211-212, 366-372 (2012-01-03) Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration.Amelie Hailer et al.Oncotarget, 5(12), 4144-4153 (2014-07-02) Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.Ismail M Meraz et al.PloS one, 9(4), e94703-e94703 (2014-04-17) Do we need covalent bonding of Si nanoparticles on graphene oxide for Li-ion batteries?Yana Miroshnikov et al.Faraday discussions, 173, 391-402 (2014-12-04) Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration.Amelie Hailer et al.Oncotarget, 5(12), 4144-4153 (2014-07-02) Development of an immunoaffinity solid phase microextraction method for the identification of penicillin binding protein 2a.Yuhong Liu et al.Journal of chromatography. A, 1364, 64-73 (2014-09-04) Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes.S R Simon Ting et al.Biomaterials, 34(17), 4377-4386 (2013-03-13) Disclosing caffeine action on insulin sensitivity: effects on rat skeletal muscle.Joana F Sacramento et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 107-116 (2015-02-11) Biocompatibility of Tygon® tubing in microfluidic cell culture.Xiao Jiang et al.Biomedical microdevices, 17(1), 20-20 (2015-02-06) Yolk@Shell Nanoarchitecture of Au@r-GO/TiO₂ Hybrids as Powerful Visible Light Photocatalysts.Minggui Wang et al.Langmuir : the ACS journal of surfaces and colloids, 31(22), 6220-6228 (2015-05-23) EDTA functionalized magnetic nanoparticle sorbents for cadmium and lead contaminated water treatment.Yuxiong Huang et al.Water research, 80, 159-168 (2015-05-23) Simplified prototyping of perfusable polystyrene microfluidics.Reginald Tran et al.Biomicrofluidics, 8(4), 046501-046501 (2014-11-08) Mesoporous Silica Nanoparticles Decorated with Carbosilane Dendrons as New Non-viral Oligonucleotide Delivery Carriers.Ángel Martínez et al.Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15651-15666 (2015-09-12) Effective removal of heavy metal ions Cd2+, Zn2+, Pb2+, Cu2+ from aqueous solution by polymer-modified magnetic nanoparticles.Fei Ge et al.Journal of hazardous materials, 211-212, 366-372 (2012-01-03) Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.Ismail M Meraz et al.PloS one, 9(4), e94703-e94703 (2014-04-17) Rechargeable, flexible and mediator-free biosupercapacitor based on transparent ITO nanoparticle modified electrodes acting in µM glucose containing buffers.Tim Bobrowski et al.Biosensors & bioelectronics, 101, 84-89 (2017-10-20) The biosynthesis, structure and gelatinization properties of starches from wild and cultivated African rice species (Oryza barthii and Oryza glaberrima).Kai Wang et al.Carbohydrate polymers, 129, 92-100 (2015-06-09) Cellular Responses Modulated by FGF-2 Adsorbed on Albumin/Heparin Layer-by-Layer Assemblies.Marta Kumorek et al.PloS one, 10(5), e0125484-e0125484 (2015-05-07) Nanoshell-mediated targeted photothermal therapy of HER2 human breast cancer cells using pulsed and continuous wave lasers: an in vitro study.Mohammad E Khosroshahi et al.Lasers in medical science, 30(7), 1913-1922 (2015-07-04) Electrochemical detection of E. coli O157:H7 using porous pseudo-carbon paste electrode modified with carboxylic multi-walled carbon nanotubes, glutaraldehyde and 3-aminopropyltriethoxysilane.Lijian Xu et al.Journal of biomedical nanotechnology, 8(6), 1006-1011 (2012-10-04) A Label-Free Impedimetric DNA Sensor Based on a Nanoporous SnO₂ Film: Fabrication and Detection Performance.Minh Hai Le et al.Sensors (Basel, Switzerland), 15(5), 10686-10704 (2015-05-09) Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding.Rahul P Bagwe et al.Langmuir : the ACS journal of surfaces and colloids, 22(9), 4357-4362 (2006-04-19) Multi-walled carbon nanotube-based ternary rare earth (Eu3+, Tb3+) hybrid materials with organically modified silica-oxygen bridge.Qiu-Ping Li et al.Journal of colloid and interface science, 380(1), 67-74 (2012-06-15) BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells.Xiaojun Zhou et al.ACS applied materials & interfaces, 7(29), 15777-15789 (2015-07-03) Platinum nanoparticles homogenously decorating multilayered reduced graphene oxide for electrical nanobiosensor applications.Proa-Coronado, et al. 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