Boiling point	140-144 ºC (17 Torr)**
Flash point	41.1±0.0 ºC, 计算值*
Density	0.818±0.06 g/cm3 (20 º
Refractive index	1.4453 (589.3 nm 13 ºC)***

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells.A Zembowicz et al.Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11172-11176 (1991-12-15) Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors.Tingwei Cai et al.Bioorganic & medicinal chemistry letters, 12(11), 1507-1510 (2002-05-29) Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.A Renodon-Cornière et al.Biochemistry, 38(15), 4663-4668 (1999-04-14) Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.David Lefèvre-Groboillot et al.Biochemistry, 42(13), 3858-3867 (2003-04-02) Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.Daniel Mansuy et al.Drug metabolism reviews, 34(3), 593-606 (2002-09-07) Oxidative denitrification of the antitumour drug hydroxyguanidine.S A Everett et al.Free radical biology & medicine, 24(1), 1-10 (1998-01-22) Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide.Rémy Ricoux et al.European journal of biochemistry, 270(1), 47-55 (2002-12-21) Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.B Clement et al.Biochemical pharmacology, 58(3), 439-445 (1999-07-29) N-Hydroxyguanidine compound 1-(3,4-dimethoxy- 2-chlorobenzylideneamino)-3-hydroxyguanidine inhibits the xanthine oxidase mediated generation of superoxide radical.M Dambrova et al.Archives of biochemistry and biophysics, 377(1), 101-108 (2000-04-25) N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.D Lefevre-Groboillot et al.Biochemistry, 40(33), 9909-9917 (2001-08-15) Novel substrates for nitric oxide synthases.Ming Xian et al.Bioorganic & medicinal chemistry, 10(9), 3049-3055 (2002-07-12) Aromatic bis-N-hydroxyguanidinium derivatives: synthesis, biophysical, and biochemical evaluations.Amila Kahvedžić et al.Journal of medicinal chemistry, 56(2), 451-459 (2012-12-21) Zembowicz, A., et al. British Journal of Pharmacology, 107, 1007-1007 (1992) Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.C Moali et al.Chemical research in toxicology, 14(2), 202-210 (2001-03-22) Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO.David Lefèvre-Groboillot et al.The FEBS journal, 272(12), 3172-3183 (2005-06-16) 1-(2-Mercaptobenzenesulfonyl)-3-hydroxyguanidines--novel potent antiproliferatives, synthesis and in vitro biological activity.Kamil Brożewicz et al.European journal of medicinal chemistry, 55, 384-394 (2012-08-16) N-hydroxyguanidines as substrates of nitric oxide synthases.T Bill Cai et al.Current topics in medicinal chemistry, 5(7), 721-736 (2005-08-17) Reaction of N-hydroxyguanidine with the ferrous-oxy state of a heme peroxidase cavity mutant: a model for the reactions of nitric oxide synthase.Alycen Pond Nigro et al.Archives of biochemistry and biophysics, 500(1), 66-73 (2010-03-30) Metalloporphyrin catalyzed oxidation of N-hydroxyguanidines: a biomimetic model for the H2O2-dependent activity of nitric oxide synthase.G M Keseru et al.Bioorganic & medicinal chemistry letters, 10(15), 1775-1777 (2000-08-11) The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?Dennis Schade et al.ChemMedChem, 4(10), 1595-1599 (2009-08-21) Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase.Patrick Slama et al.Biochemical and biophysical research communications, 316(4), 1081-1087 (2004-03-27) Alternative nitric oxide-producing substrates for NO synthases.Daniel Mansuy et al.Free radical biology & medicine, 37(8), 1105-1121 (2004-09-29) N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase.Patrick Slama et al.Journal of inorganic biochemistry, 103(3), 455-462 (2009-01-31) A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.Qingzhi Zhang et al.Chemical communications (Cambridge, England), 49(14), 1389-1391 (2013-01-17) The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis.Huiying Li et al.Biochemistry, 41(47), 13868-13875 (2002-11-20) Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase.J Hirst et al.The Journal of biological chemistry, 275(12), 8582-8591 (2000-03-18) Cardioprotective effects of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats.M Veveris et al.British journal of pharmacology, 128(5), 1089-1097 (1999-11-11) [Design, synthesis and antiasthmatic activities of NO-donating seratrodast derivatives].Zhi-guo Zhang et al.Yao xue xue bao = Acta pharmaceutica Sinica, 39(9), 705-710 (2004-12-21)

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