Water Solubility	Miscible
Boiling point	90-91 ºC
Flash point	-18 ºC
Density	0.91
Refractive index	1.469-1.471

Symbol(GHS)	F;C
Hazard Codes	R11;R34
SDS/MSDS	S16;S26;S36/37/39;S45

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.Matthew K Brittain et al.Neuropharmacology, 63(6), 974-982 (2012-07-24) Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis.Pallab Bhattacharya et al.Medical hypotheses, 79(4), 516-518 (2012-08-10) Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels.Andrew J Delaney et al.Journal of neurophysiology, 107(6), 1571-1575 (2011-12-30) Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.A H Shin et al.British journal of pharmacology, 166(3), 1002-1017 (2011-12-07) Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.Qin Yang et al.EBioMedicine, 47, 470-483 (2019-09-03) Ifenprodil for emotional incontinence in patients with vascular dementia: two case reports.Akira Kishimoto et al.Journal of clinical psychopharmacology, 33(1), 143-145 (2013-01-05) Ifenprodil for the treatment of flashbacks in adolescent female posttraumatic stress disorder patients with a history of abuseSasaki T, et al. Psychotherapy and Psychosomatics, 82(5), 344-345 (2013) Ifenprodil for the treatment of flashbacks in female posttraumatic stress disorder patients with a history of childhood sexual abuse.Akira Kishimoto et al.Biological psychiatry, 71(4), e7-e8 (2011-11-11) Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor.Kay-Siong Ng et al.The Journal of biological chemistry, 287(30), 25520-25529 (2012-05-23) Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.Mónica Santos et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(38), 15259-15271 (2013-09-21) Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine.J Kurihara et al.European journal of pharmacology, 190(1-2), 23-30 (1990-11-06) Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil.Hideyuki Tomitori et al.The Journal of pharmacology and experimental therapeutics, 343(1), 82-90 (2012-06-30) Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons.Hjalte M Larsen et al.Stem cell research, 41, 101642-101642 (2019-11-11) Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.T R Butler et al.Neuroscience, 165(2), 525-534 (2009-10-20) Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.Austen J Milnerwood et al.Neurobiology of disease, 48(1), 40-51 (2012-06-07) Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.Pieter B Burger et al.Molecular pharmacology, 82(2), 344-359 (2012-05-19) Anti?epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical developmentWang X, et al. Experimental and Therapeutic Medicine, 14(6), 5757-5766 (2017) Properties of doublecortin expressing neurons in the adult mouse dentate gyrus.Jay Spampanato et al.PloS one, 7(9), e41029-e41029 (2012-09-08) Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.Haowei Shen et al.Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19407-19412 (2011-11-16) Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating.Jay M Bhatt et al.Molecular pharmacology, 83(1), 9-21 (2012-09-26) Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRIShatillo A, et al. Neuropharmacology, 93, 164-170 (2015) Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.Youngkyung Kim et al.Pain, 153(5), 1022-1029 (2012-03-20) Ifenprodil effects on GluN2B-containing glutamate receptors.Stacy A Amico-Ruvio et al.Molecular pharmacology, 82(6), 1074-1081 (2012-09-01) Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.Tamaki Ishima et al.PloS one, 7(5), e37989-e37989 (2012-06-02) Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates.Patrice Marchand et al.Bioconjugate chemistry, 23(1), 21-26 (2011-12-14) NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylationShen L, et al. Molecular Brain, 11(1), 35-35 (2018) On mechanism of allosteric modulation of NMDA receptor via amino-terminal domains.D S Karlov et al.Biochemical and biophysical research communications, 424(4), 687-690 (2012-07-14) Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodilKobayashi T, et al. Neuropsychopharmacology, 31(3), 516-516 (2006) Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs.Kenneth R Tovar et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(23), 8065-8073 (2012-06-08) Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.Amy L Milton et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 1109-1115 (2013-01-18) A critical role for GluN2B-containing NMDA receptors in cortical development and function.Chih-Chieh Wang et al.Neuron, 72(5), 789-805 (2011-12-14) Antagonists selective for NMDA receptors containing the NR2B subunit.B L Chenard et al.Current pharmaceutical design, 5(5), 381-404 (1999-04-24) Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions.Shauna L Parkes et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8753-8763 (2013-05-17) Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.Andrew J Delaney et al.Journal of neurophysiology, 109(5), 1391-1402 (2012-12-12) The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation.Zdeňka Bendová et al.Neurochemistry international, 61(1), 43-47 (2012-05-01) Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.Leonardo Magno Rambo et al.Brain research bulletin, 88(6), 553-559 (2012-06-30) The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.Agnes R Banreti et al.Nature communications, 11(1), 2228-2228 (2020-05-08) Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor.C Carter et al.European journal of pharmacology, 164(3), 611-612 (1989-05-30)

Remarks