Melting point	-75 ºC***
Boiling point	91-92 ºC****
Flash point	1.7±0.0 ºC, 计算值*
Density	0.7637 g/cm3 (15 ºC)**
Refractive index	1.4045 (589.3 nm 16 ºC)****

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Source	SDS/MSDS Samples
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Articles

Peer-Reviewed Papers

Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.Julia Tischler et al.The EMBO journal, 38(1) (2018-09-28) Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.Jing-Jing Wang et al.Oncoimmunology, 8(11), e1659092-e1659092 (2019-10-28) Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.Julia Tischler et al.The EMBO journal, 38(1) (2018-09-28) Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.Han Shen et al.Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13) Homogeneous photocatalytic Fe3+/Fe2+ redox cycle for simultaneous Cr(VI) reduction and organic pollutant oxidation: Roles of hydroxyl radical and degradation intermediates.Dong-Hyo Kim et al.Journal of hazardous materials, 372, 121-128 (2018-04-11) Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: design, synthesis and biological evaluation.Yongchong Yang et al.European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29) Combining lipoic acid to methylene blue reduces the Warburg effect in CHO cells: From TCA cycle activation to enhancing monoclonal antibody production.Léa Montégut et al.PloS one, 15(4), e0231770-e0231770 (2020-04-17) Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells.Fernando Erra Díaz et al.Cell reports, 31(5), 107613-107613 (2020-05-07) Activation of Pyruvate Dehydrogenase Activity by Dichloroacetate Improves Survival and Neurologic Outcomes After Cardiac Arrest in Rats.Peng Wang et al.Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29) Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.Strum SB., et al. Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013) CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases.Roald A Lambrechts et al.EMBO molecular medicine, 11(12), e10488-e10488 (2019-11-09) Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.Jing-Jing Wang et al.Oncoimmunology, 8(11), e1659092-e1659092 (2019-10-28) Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.Han Shen et al.Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13) The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.Ruoyan Xu et al.EMBO reports, 21(9), e48260-e48260 (2020-08-13) Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence.Michal Harel et al.Cell, 179(1), 236-250 (2019-09-10) Dual-targeting of aberrant glucose metabolism in glioblastoma.Han Shen et al.Journal of experimental & clinical cancer research : CR, 34, 14-14 (2015-02-06) Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma.Gang Meng et al.British journal of cancer, 122(1), 111-120 (2019-12-11) Metabolic requirements of Besnoitia besnoiti tachyzoite-triggered NETosis.Ershun Zhou et al.Parasitology research, 119(2), 545-557 (2019-11-30) Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.Chiara Agnoletto et al.Oncotarget, 5(12), 4347-4360 (2014-06-26) Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate.M V Filimonova et al.Bulletin of experimental biology and medicine, 168(1), 92-94 (2019-11-27) Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.Pathak RK, et al. ACS Chemical Biology, 9(5), 1178-1187 (2014) Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.Valentina Sica et al.Cell reports, 27(3), 820-834 (2019-04-18) Evaluation of cell metabolic adaptation in wound and tumour by Fluorescence Lifetime Imaging Microscopy.Diego Morone et al.Scientific reports, 10(1), 6289-6289 (2020-04-15) Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.Ian F Robey et al.BMC cancer, 11, 235-235 (2011-06-15) Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments.Mario Ammendola et al.Scientific reports, 10(1), 6521-6521 (2020-04-18) HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.Jason Miska et al.Cell reports, 27(1), 226-237 (2019-04-04) Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility.Shuang Peng et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 58, 152745-152745 (2019-04-22) Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary.Rachel Cinco et al.Biology of reproduction, 95(6), 129-129 (2016-09-30) Inhibition of retinoic acid receptor β signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells.Cecilie Abildgaard et al.Oncotarget, 8(48), 84210-84223 (2017-11-16) Antitumor activity of potent pyruvate dehydrogenase kinase 4 inhibitors from plants in pancreatic cancer.Yukihiro Tambe et al.Molecular carcinogenesis, 58(10), 1726-1737 (2019-05-21) Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells.Fengsen Duan et al.Scientific reports, 10(1), 7714-7714 (2020-05-10) Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells.Won Dong Lee et al.Nature communications, 10(1), 1351-1351 (2019-03-25) Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.Atkinson JD & Rood MJ. Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012) Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.Marie-Aline Neveu et al.Oncotarget, 7(49), 81741-81749 (2017-01-14) A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene.Eun-Ha Lee et al.Journal of Korean medical science, 21(5), 800-804 (2006-10-18) Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms.Jiajun Huang et al.EBioMedicine, 45, 251-260 (2019-06-16) Broadening the phenotypic spectrum of Pearson syndrome: Five new cases and a review of the literature.K Taylor Wild et al.American journal of medical genetics. Part A, 182(2), 365-373 (2019-12-12) Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.Debabrata Chowdhury et al.Cell reports, 27(13), 3873-3886 (2019-06-27) Why do some ME/CFS patients benefit from treatment with sodium dichloroacetate, but others do not?Frank Comhaire Medical hypotheses, 120, 65-67 (2018-09-18) Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.Wenjing Ma et al.Cancer biology & therapy, 19(9), 835-846 (2018-08-02)

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