Melting point	-51 ºC
Water Solubility	practically insoluble
Boiling point	130-131 ºC
Flash point	31 ºC
Density	0.951
Refractive index	1.436-1.438

Symbol(GHS)	Xi
Hazard Codes	R10;R36/38
SDS/MSDS	S23

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Microfluidic chip with thermoresponsive boronate affinity for the capture-release of cis-diol biomolecules.Yan Man et al.Journal of separation science, 38(2), 339-345 (2014-11-08) Probing particle heteroaggregation using analytical centrifugation.Marcel Rey et al.Soft matter, 16(14), 3407-3415 (2020-03-11) Swelling kinetics of microgels embedded in a polyacrylamide hydrogel matrix.Na Huang et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 15(9), 1785-1792 (2014-05-28) Thermal-induced Immuno-nephelometry Using Gold Nanoparticles Conjugated with a Thermoresponsive Polymer for the Detection of Avidin.Nobuo Uehara et al.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(6), 495-501 (2015-06-13) Influence of galactomannan molar mass on particle size galactomannan-grafted-poly-N-isopropylacrylamide copolymers.Raelle F Gomes et al.International journal of biological macromolecules, 156, 446-453 (2020-04-12) Smart thermo/pH responsive magnetic nanogels for the simultaneous delivery of doxorubicin and methotrexate.Roya Salehi et al.International journal of pharmaceutics, 487(1-2), 274-284 (2015-04-22) N-isopropylacrylamide-modified polyethylenimines as effective gene carriers.Huayu Tian et al.Macromolecular bioscience, 12(12), 1680-1688 (2012-11-07) N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells.Jianxu Zhang et al.Colloids and surfaces. B, Biointerfaces, 129, 54-62 (2015-04-02) Magnetic, fluorescent, and thermo-responsive poly(MMA-NIPAM-Tb(AA)3Phen)/Fe3O4 multifunctional nanospheres prepared by emulsifier-free emulsion polymerization.Ying Gong et al.Journal of biomaterials applications, 30(2), 201-211 (2015-03-15) Cellular responses to beating hydrogels to investigate mechanotransduction.Yashoda Chandorkar et al.Nature communications, 10(1), 4027-4027 (2019-09-08) Bioprospecting the American alligator (Alligator mississippiensis) host defense peptidome.Barney M Bishop et al.PloS one, 10(2), e0117394-e0117394 (2015-02-12) Thermo-responsive polymeric nanoparticles for enhancing neuronal differentiation of human induced pluripotent stem cells.Hye In Seo et al.Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1861-1869 (2015-06-21) Intermolecular approach to metal ion indicators based on polymer phase transitions coupled to fluorescence resonance energy transfer.Shaojun Yao et al.The Analyst, 137(20), 4734-4741 (2012-08-23) Amine-reactive polymers synthesized by RAFT polymerization using an azlactone functional trithiocarbonate RAFT agent.Hien The Ho et al.Macromolecular rapid communications, 33(20), 1753-1758 (2012-07-13) Poly(N-isopropylacrylamide-co-methacrylic acid) pH/thermo-responsive porous hydrogels as self-regulated drug delivery system.Marieta Constantin et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 86-95 (2014-05-23) Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles.Ulrike Wais et al.Journal of controlled release : official journal of the Controlled Release Society, 222, 141-150 (2015-12-26) Faster droplet production by delayed surfactant-addition in two-phase microfluidics to form thermo-sensitive microgels.Sebastian Seiffert et al.Journal of colloid and interface science, 452, 38-42 (2015-04-29) Preparation and characterisation of thermoresponsive nanogels for smart antibacterial fabrics.Muhammad Zafar et al.Materials science & engineering. C, Materials for biological applications, 40, 135-141 (2014-05-27) Process analytical approaches for the coil-to-globule transition of poly(N-isopropylacrylamide) in a concentrated aqueous suspension.Peter Werner et al.Analytical and bioanalytical chemistry, 409(3), 807-819 (2016-11-11) Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery.Rimesh Augustine et al.Journal of materials chemistry. B, 8(26), 5745-5755 (2020-06-11) Stretching of collapsed polymers causes an enhanced dissipative response of PNIPAM brushes near their LCST.Yunlong Yu et al.Soft matter, 11(43), 8508-8516 (2015-09-16) A fluorescent responsive hybrid nanogel for closed-loop control of glucose.Weitai Wu et al.Journal of diabetes science and technology, 6(4), 892-901 (2012-08-28) Polymerizing nonfluorescent monomers without incorporating any fluorescent agent produces strong fluorescent polymers.Jun-Jie Yan et al.Advanced materials (Deerfield Beach, Fla.), 24(41), 5617-5624 (2012-08-29) Effect of composition interactions on the dose response of an N-isopropylacrylamide gel dosimeter.Yuan-Jen Chang et al.PloS one, 7(10), e44905-e44905 (2012-10-19) Light-triggered concomitant enhancement of magnetic resonance imaging contrast performance and drug release rate of functionalized amphiphilic diblock copolymer micelles.Yamin Li et al.Biomacromolecules, 13(11), 3877-3886 (2012-09-28) Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators.Fernando Benito-Lopez et al.Lab on a chip, 14(18), 3530-3538 (2014-07-16) 4D Printing with Mechanically Robust, Thermally Actuating Hydrogels.Shannon E Bakarich et al.Macromolecular rapid communications, 36(12), 1211-1217 (2015-04-14) Fundamental Study of Emulsions Stabilized by Soft and Rigid Particles.Zifu Li et al.Langmuir : the ACS journal of surfaces and colloids, 31(23), 6282-6288 (2015-04-04) Smart nanogels at the air/water interface: structural studies by neutron reflectivity.Katarzyna Zielińska et al.Nanoscale, 8(9), 4951-4960 (2015-12-25) Impact of heating method on the flocculation process using thermosensitive polymer.Marcin Lemanowicz et al.Water research, 46(13), 4091-4098 (2012-06-05) Thermally Switchable Liquid Crystals Based on Cellulose Nanocrystals with Patchy Polymer Grafts.Bailey Risteen et al.Small (Weinheim an der Bergstrasse, Germany), 14(46), e1802060-e1802060 (2018-09-11) Integrated system for temperature-controlled fast protein liquid chromatography comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor arrangement.Tobias K H Müller et al.Journal of chromatography. A, 1285, 97-109 (2013-03-14) Synthesis of two thermo-responsive copolymers forming recyclable aqueous two-phase systems and its application in cefprozil partition.Daisong Hou et al.Journal of chromatography. A, 1349, 30-36 (2014-05-27) Epitope approach in molecular imprinting of antibodies.Ewa Moczko et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1124, 1-6 (2019-06-09) Meunier, F., Elaissari, A. Surfactant Science Series, 115, 117-117 (2003) A novel, smart microsphere with K(+)-induced shrinking and aggregating properties based on a responsive host-guest system.Ming-Yue Jiang et al.ACS applied materials & interfaces, 6(21), 19405-19415 (2014-10-18) Detection of Peptide-based nanoparticles in blood plasma by ELISA.Gerard H Bode et al.PloS one, 10(5), e0126136-e0126136 (2015-05-23) [Controlled release using temperature-responsive poly(N-isopropylacrylamide) gel].R Yoshida Nihon rinsho. Japanese journal of clinical medicine, 56(3), 670-674 (1998-04-29) Novel semi-interpenetrating hydrogel networks with enhanced mechanical properties and thermoresponsive engineered drug delivery, designed as bioactive endotracheal tube biomaterials.David S Jones et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(3), 563-571 (2012-09-04) Kinetic studies and model development for the formation of galacto-oligosaccharides from lactose using synthesized thermo-responsive bioconjugate.Tapas Palai et al.Enzyme and microbial technology, 70, 42-49 (2015-02-11) Abatement of aqueous anionic contaminants by thermo-responsive nanocomposites: (poly(N-isopropylacrylamide))-co-silylanized magnesium/aluminun layered double hydroxides.Hua Chen et al.Journal of colloid and interface science, 448, 65-72 (2015-02-28) Peptide/protein separation with cationic polymer brush nanosponges for MALDI-MS analysis.Bojan Mitrovic et al.Langmuir : the ACS journal of surfaces and colloids, 29(2), 696-700 (2012-12-19) Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea.Natalya Doroshenko et al.Biomaterials science, 6(8), 2101-2109 (2018-06-09) Poly(Ionic Liquid) Semi-Interpenetrating Network Multi-Responsive Hydrogels.Alexandru Tudor et al.Sensors (Basel, Switzerland), 16(2), 219-219 (2016-02-11) Magnetic molecularly imprinted polymers prepared by reversible addition fragmentation chain transfer polymerization for dispersive solid phase extraction of polycyclic aromatic hydrocarbons in water.Ali Azizi et al.Journal of chromatography. A, 1610, 460534-460534 (2019-09-22) Distribution of locally delivered antimicrobials is limited by cortical bone: a pilot study.Ryan Odgers et al.Clinical orthopaedics and related research, 471(10), 3141-3146 (2013-02-23) Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing.Shixuan Chen et al.Scientific reports, 5, 18104-18104 (2015-12-09) CORR Insights®: distribution of locally delivered antimicrobials is limited by cortical bone: a pilot study.Arvind D Nana Clinical orthopaedics and related research, 471(10), 3147-3148 (2013-08-13) Efficient targeted cancer cell detection, isolation and enumeration using immuno-nano/hybrid magnetic microgels.Amir Seyfoori et al.Biomaterials science, 7(8), 3359-3372 (2019-06-25) Autonomous and Continuous Stimuli-Responsive Polymer Surface for Antibacterial Application through Enzymatic Self-Propagating Reactions.Chao Ding et al.Chemistry (Weinheim an der Bergstrasse, Germany), 23(59), 14883-14888 (2017-08-05) Temperature-responsive polymers for cell culture and tissue engineering applications Switchable and Responsive Surfaces and Materials for Biomedical Applications, 32(5), 203-233 (2015) Synthesis of vinyl-terminated Au nanoprisms and nanooctahedra mediated by 3-butenoic acid: direct Au@pNIPAM fabrication with improved SERS capabilities.M A Casado-Rodriguez et al.Nanoscale, 8(8), 4557-4564 (2016-01-30) Temperature-sensitive hydrogels by graft polymerization of chitosan and N-isopropylacrylamide for drug release.Umile Gianfranco Spizzirri et al.Pharmaceutical development and technology, 18(5), 1026-1034 (2011-12-28) Tunable thermo-responsive hydrogels: synthesis, structural analysis and drug release studies.Giuseppe Cirillo et al.Materials science & engineering. C, Materials for biological applications, 48, 499-510 (2015-01-13) Poly (N-Isopropylacrylamide) microgel-based optical devices for humidity sensing.Molla R Islam et al.Analytica chimica acta, 898, 101-108 (2015-11-04) Injectable hydrogel as stem cell scaffolds from the thermosensitive terpolymer of NIPAAm/AAc/HEMAPCL.Sheng Lian et al.International journal of nanomedicine, 7, 4893-4905 (2012-10-03) Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine, 34(9), 161-186 (2017) Concave microwell array-mediated three-dimensional tumor model for screening anticancer drug-loaded nanoparticles.AhRan Kang et al.Nanomedicine : nanotechnology, biology, and medicine, 11(5), 1153-1161 (2015-03-11) Anions make the difference: insights from the interaction of big cations and anions with poly(N-isopropylacrylamide) chains and microgels.Leonor Pérez-Fuentes et al.Soft matter, 11(25), 5077-5086 (2015-06-02) Bioinspired programmable wettability arrays for droplets manipulation.Lingyu Sun et al.Proceedings of the National Academy of Sciences of the United States of America, 117(9), 4527-4532 (2020-02-20) Thermoresponsive copolymer/SiO2 nanoparticles with dual functions of thermally controlled drug release and simultaneous carrier decomposition.Aihua Li et al.Chemistry (Weinheim an der Bergstrasse, Germany), 20(40), 12945-12953 (2014-08-12) Characterisation of biomedical coatings Coatings for Biomedical Applications, 32(5), 176-220 (2012) Poly(N-isopropylacrylamide)-clay based hydrogels controlled by the initiating conditions: evolution of structure and gel formation.Beata Strachota et al.Soft matter, 11(48), 9291-9306 (2015-10-03) Dynamics in N-isopropylacrylamide-acrylic acid copolymer aqueous solution from mechanical spectroscopy.Huaguang Wang et al.The journal of physical chemistry. B, 116(45), 13411-13415 (2012-10-31) Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples.Homayon Ahmad Panahi et al.Journal of chromatography. A, 1345, 37-42 (2014-05-02) Localized delivery of doxorubicin in vivo from polymer-modified thermosensitive liposomes with MR-guided focused ultrasound-mediated heating.Terence Ta et al.Journal of controlled release : official journal of the Controlled Release Society, 194, 71-81 (2014-08-26) Electrostatic Self-Assembly of Au Nanoparticles onto Thermosensitive Magnetic Core-Shell Microgels for Thermally Tunable and Magnetically Recyclable Catalysis.Guoqiang Liu et al.Small (Weinheim an der Bergstrasse, Germany), 11(23), 2807-2816 (2015-02-05) A smart nanofiber web that captures and releases cells.Young-Jin Kim et al.Angewandte Chemie (International ed. in English), 51(42), 10537-10541 (2012-09-20) Colloidal Plastic Crystals in a Shear Field.Fangfang Chu et al.Langmuir : the ACS journal of surfaces and colloids, 31(22), 5992-6000 (2015-01-31) Au@pNIPAM SERRS Tags for Multiplex Immunophenotyping Cellular Receptors and Imaging Tumor Cells.Gustavo Bodelón et al.Small (Weinheim an der Bergstrasse, Germany), 11(33), 4149-4157 (2015-05-06) Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles.Juan M Giussi et al.Nanoscale, 10(3), 1189-1195 (2017-12-23) Synthesis and application of hybrid polymer composites based on silver nanoparticles as corrosion protection for line pipe steel.Ayman M Atta et al.Molecules (Basel, Switzerland), 19(5), 6246-6262 (2014-05-21) A pH gated, glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release.Lei Sun et al.The journal of physical chemistry. B, 117(14), 3852-3860 (2013-03-23) Controlled release of lipase from Candida rugosa loaded into hydrogels of N-isopropylacrylamide and itaconic acid.Nikola Milašinović et al.International journal of pharmaceutics, 436(1-2), 332-340 (2012-07-05) Doubly thermo-responsive copolymers in ionic liquid.H H Nguyen et al.Soft matter, 12(13), 3246-3251 (2016-03-05) Raman spectroscopy as a tool to evaluate oxygen effects on the response of polymer gel dosimetry.D Chacón et al.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 150, 43-52 (2019-05-24) Enhanced delivery of naproxen to the viable epidermis from an activated poly N-isopropylacrylamide (PNIPAM) Nanogel: Skin penetration, modulation of COX-2 expression and rat paw oedema.Aysu Yurdasiper et al.Nanomedicine : nanotechnology, biology, and medicine, 14(7), 2051-2059 (2018-07-01) Protein crystallization and biosensor applications of hydrogel-based molecularly imprinted polymers.Subrayal M Reddy et al.Biomacromolecules, 13(12), 3959-3965 (2012-10-31) Thermally programmable pH buffers.Dara Van Gough et al.ACS applied materials & interfaces, 4(11), 6247-6251 (2012-11-08) Preparation of thermo-responsive PNIPAAm-MWCNT membranes and evaluation of its antifouling properties in dairy wastewater.Zeynab Yaghoubi et al.Materials science & engineering. C, Materials for biological applications, 103, 109779-109779 (2019-07-28) Temperature-Responsive Poly(N-isopropylacrylamide) Modified Gold Nanoparticle-Protein Conjugates for Bioactivity Modulation.Feng Liu et al.ACS applied materials & interfaces, 7(21), 11547-11554 (2015-05-08) Shell cross-linking of cyclodextrin-based micelles via supramolecular chemistry for the delivery of drugs.Firdaus Yhaya et al.Macromolecular rapid communications, 33(21), 1868-1874 (2012-08-24) Fabrication and aggregation of thermoresponsive glucose-functionalized double hydrophilic copolymers.Shao-Feng Lou et al.Colloids and surfaces. B, Biointerfaces, 105, 180-186 (2013-02-13) Functionalized thermo-responsive microgels for high performance forward osmosis desalination.Yusak Hartanto et al.Water research, 70, 385-393 (2014-12-31) Photoisomerizable and thermoresponsive N-isopropylacrylamide-surfmer copolymer hydrogels prepared upon electrostatic self-assembly of an azobenzene bolaamphiphile.Tatjana Friedrich et al.Macromolecular rapid communications, 34(5), 393-398 (2013-01-29) Controlled release of antibiotics from photopolymerized hydrogels: Kinetics and microbiological studies.Antonela Gallastegui et al.Materials science & engineering. C, Materials for biological applications, 102, 896-905 (2019-05-31) Magnetocaloric effect in magnetothermally-responsive nanocarriers for hyperthermia-triggered drug release.Jianbo Li et al.Nanotechnology, 23(50), 505706-505706 (2012-11-28) Tat/HA2 Peptides Conjugated AuNR@pNIPAAm as a Photosensitizer Carrier for Near Infrared Triggered Photodynamic Therapy.Shefang Ye et al.Molecular pharmaceutics, 12(7), 2444-2458 (2015-06-03) Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas.Ganjun Feng et al.Biomaterials, 52, 1-13 (2015-03-31) A thermoresponsive biodegradable polymer with intrinsic antioxidant properties.Jian Yang et al.Biomacromolecules, 15(11), 3942-3952 (2014-10-09) Thermo-sensitive polymeric micelles based on poly (N-isopropylacrylamide) as drug carriersWei H, et al. Progress in Polymer Science, 34(9), 893-910 (2009) Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.Mahesh D Pawar et al.Materials science & engineering. C, Materials for biological applications, 48, 126-137 (2015-01-13) Unusual and Superfast Temperature-Triggered Actuators.Shaohua Jiang et al.Advanced materials (Deerfield Beach, Fla.), 27(33), 4865-4870 (2015-07-18) The effectively specific recognition of bovine serum albumin imprinted silica nanoparticles by utilizing a macromolecularly functional monomer to stabilize and imprint template.Liwei Qian et al.Analytica chimica acta, 884, 97-105 (2015-06-16) Degradable nanohydrogel with high doxorubicin loadings exhibiting controlled drug release and decreased toxicity against healthy cells.Ewelina Waleka et al.International journal of pharmaceutics, 579, 119188-119188 (2020-03-03) Stick-slip water penetration into capillaries coated with swelling hydrogel.J E Silva et al.Soft matter, 11(29), 5933-5939 (2015-06-30) Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide).I M Pilipenko et al.Carbohydrate polymers, 248, 116764-116764 (2020-09-14) Saunders, B.R. Surfactant Science Series, 115, 419-419 (2003) Use of poly(N-isopropylacrylamide) nanohydrogels for the controlled release of pimaricin in active packaging.C Fuciños et al.Journal of food science, 77(7), N21-N28 (2012-07-05) pH triggered in vivo photothermal therapy and fluorescence nanoplatform of cancer based on responsive polymer-indocyanine green integrated reduced graphene oxide.Shazid Md Sharker et al.Biomaterials, 61, 229-238 (2015-05-26) Functional copolymers of N-isopropylacrylamide for bioengineering applicationsRzaev ZMO, et al. Progress in Polymer Science, 32(5), 534-595 (2007) Chemokine-Releasing Nanoparticles for Manipulation of Lymph Node Microenvironment.Taissia G Popova et al.Nanomaterials (Basel, Switzerland), 5(1), 298-320 (2015-04-17) Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?Zeynep Altintas et al.Biosensors & bioelectronics, 74, 996-1004 (2015-08-13) Light-Induced Polymer Response through Thermoplasmonics Transduction in Highly Monodisperse Core-Shell-Brush Nanosystems.María Jazmín Penelas et al.Langmuir : the ACS journal of surfaces and colloids, 36(8), 1965-1974 (2020-02-08) Hybrid collagen-based hydrogels with embedded montmorillonite nanoparticles.Manuela Tatiana Nistor et al.Materials science & engineering. C, Materials for biological applications, 53, 212-221 (2015-06-05) Thermoresponsive chitosan/N-isopropylacrylamide copolymer through atom transfer radical polymerization.S Ifuku et al.International journal of biological macromolecules, 52, 14-19 (2012-10-23) Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K.Hollie Hathaway et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 437-441 (2015-10-02) In situ forming, resorbable graft copolymer hydrogels providing controlled drug release.Derek J Overstreet et al.Journal of biomedical materials research. Part A, 101(5), 1437-1446 (2012-11-02) Strengthening injectable thermo-sensitive NIPAAm-g-chitosan hydrogels using chemical cross-linking of disulfide bonds as scaffolds for tissue engineering.Shu-Wei Wu et al.Carbohydrate polymers, 192, 308-316 (2018-04-25) Preparation and characterization of a thermoresponsive gigaporous medium for high-speed protein chromatography.Jian-Bo Qu et al.Analytica chimica acta, 853, 617-624 (2014-12-04) Volume transition and adhesion force of nanosized bifunctional spherical polyelectrolyte brushes observed by dynamic light scattering and atomic force microscopy.Shibin Huang et al.The journal of physical chemistry. B, 116(33), 10079-10088 (2012-07-28) Synthesis and characterization of pH sensitive hydrogel nanoparticles based on poly(N-isopropyl acrylamide-co-methacrylic acid).C E Belman-Flores et al.Journal of materials science. Materials in medicine, 31(8), 61-61 (2020-07-23) On the temperature-responsive polymers and gels based on N-propylacrylamides and N-propylmethacrylamidesKano M and Kokufuta E Langmuir, 25(15), 8649-8655 (2009) Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels.Amit K Jha et al.PloS one, 9(6), e98640-e98640 (2014-06-18) The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs.Catarina Leite Pereira et al.Biomaterials, 35(28), 8144-8153 (2014-06-28)

Remarks