Melting point	24 ºC
Water Solubility	slightly soluble
Boiling point	256 ºC
Flash point	104 ºC
Density	1.168
Refractive index	1.581-1.584

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

In vitro approach to predict post-translational phosphorylation response to mixtures.Jonathan Boyd et al.Toxicology, 313(2-3), 113-121 (2012-11-14) Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis.Lauren Arms et al.American journal of physiology. Renal physiology, 301(2), F252-F262 (2011-06-03) A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.Young-Ah Suh et al.Cancer letters, 332(1), 102-109 (2013-01-26) Activation of STAT1 is required for interferon-alpha-mediated cell death.Velmurugesan Arulampalam et al.Experimental cell research, 317(1), 9-19 (2010-10-13) Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.Bin-Chuan Ji et al.Oncology reports, 27(4), 959-964 (2012-01-10) Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.Rajeshwari R Mehta et al.Clinical & experimental metastasis, 30(7), 855-866 (2013-05-07) Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.Jong K Woo et al.Cancer prevention research (Philadelphia, Pa.), 2(4), 361-369 (2009-04-02) Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.Shigeki Ito et al.Leukemia research, 34(3), 352-357 (2009-09-29) [Separation and preparation of two rotenoids from the roots of Derris by high-speed counter-current chromatography].Wei Ji et al.Se pu = Chinese journal of chromatography, 28(8), 813-816 (2011-01-26) Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.Patrick Paulus et al.PloS one, 7(6), e39265-e39265 (2012-06-30) Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors.Jonathan Boyd et al.Chemical research in toxicology, 24(8), 1242-1250 (2011-07-14) [Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].Zhao-hui Chu et al.Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 9(5), 533-538 (2011-05-14) A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin.Jennifer M Rodenberg et al.Cancer prevention research (Philadelphia, Pa.), 2(11), 915-918 (2009-10-29) Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.Hyunseung Lee et al.Oncology reports, 24(4), 957-963 (2010-09-03) Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.José Garcia et al.Chemistry (Weinheim an der Bergstrasse, Germany), 16(32), 9767-9771 (2010-06-24) Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.Dong-Jo Chang et al.Journal of medicinal chemistry, 55(24), 10863-10884 (2012-11-29) Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.Vijayalakshmi Thamilselvan et al.International journal of cancer, 129(12), 2916-2927 (2011-04-08) Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model.Jia Hu et al.International journal of cancer, 127(10), 2455-2466 (2010-02-18) Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells.Yan-li Yang et al.PloS one, 8(1), e54736-e54736 (2013-02-02) Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro.Yan Chen et al.International journal of hematology, 89(5), 618-623 (2009-05-21) Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system.Ke Men et al.Nanoscale, 4(20), 6425-6433 (2012-09-08) Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.Hyoun Woo Kang et al.Digestive diseases and sciences, 57(11), 2873-2882 (2012-05-25) Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.Genoveva Murillo et al.Cancer prevention research (Philadelphia, Pa.), 2(11), 942-950 (2009-10-29) Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells.Rui Li et al.International journal of hematology, 89(5), 628-635 (2009-04-15) Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy.Sebastian J Buss et al.American journal of physiology. Heart and circulatory physiology, 302(2), H420-H430 (2011-11-08) Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.José Garcia et al.Bioorganic & medicinal chemistry, 20(2), 672-680 (2011-11-01) The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.Regan M Memmott et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 16(1), 4-10 (2009-12-24)

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