没有数据	没有数据

Symbol(GHS)	Xn
Hazard Codes	R10;R36/37/38;R40;R43
SDS/MSDS	S26;S36/37

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.Mihaela Necula et al.The Journal of biological chemistry, 282(14), 10311-10324 (2007-02-08) Cheminformatics based 3D-QSAR study on a series of 1,2-naphthoquinone derivatives as PTP 1B inhibitors.Payal Pahwa et al.Acta poloniae pharmaceutica, 69(3), 535-543 (2012-05-19) [Chemical biology of 1,2-naphthoquinone, a novel air pollutant that affects signal transduction pathways].Daigo Sumi et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127(12), 1949-1956 (2007-12-07) Biocompatible micelles based on comb-like PEG derivates: formation, characterization, and photo-responsiveness.Chao-Jian Chen et al.Macromolecular rapid communications, 32(14), 1077-1081 (2011-06-16) Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.Sanjeev Kumar et al.Journal of medicinal chemistry, 51(6), 1706-1718 (2008-03-06) Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor.Noriko Iwamoto et al.The Journal of biological chemistry, 282(46), 33396-33404 (2007-09-20) GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.Takashi Miura et al.Chemical research in toxicology, 24(11), 1836-1844 (2011-08-11) Structure-activity relationships and mechanism of action of tetragomycin derivatives as inhibitors of Staphylococcus aureus staphyloxanthin biosynthesis.L M B C Ribeiro et al.Microbial pathogenesis, 144, 104127-104127 (2020-03-15) Pin1 blockade in asthma by naphthoquinone?Ken-Ichiro Inoue et al.The Journal of allergy and clinical immunology, 121(4), 1064-1064 (2008-03-04) Reduction of lipid peroxidation products and advanced glycation end-product precursors by cyanobacterial aldo-keto reductase AKR3G1—a founding member of the AKR3G subfamily.Jan Hintzpeter et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 263-273 (2014-11-08) Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ).Soraia K P Costa et al.Archives of toxicology, 84(2), 109-117 (2009-04-29) A new method and tool for detection and quantification of PM oxidative potential.Francesco Ciriello et al.Environmental science and pollution research international, 22(16), 12469-12478 (2015-04-24) Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component.Wan-Yun Cheng et al.Environmental health perspectives, 120(2), 267-274 (2011-10-15) Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Janice L Hyatt et al.Journal of medicinal chemistry, 50(23), 5727-5734 (2007-10-19) Synthesis, characterization and antiproliferative activity of 1,2-naphthoquinone and its derivatives.S Shukla et al.Applied biochemistry and biotechnology, 167(5), 1430-1445 (2012-01-20) Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone.Takashi Miura et al.Chemical research in toxicology, 24(4), 559-567 (2011-03-10) Biodegradation of 2-naphthol and its metabolites by coupling Aspergillus niger with Bacillus subtilis.Shuyan Zang et al.Journal of environmental sciences (China), 22(5), 669-674 (2010-07-09) Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation.Takashi Miura et al.The Journal of toxicological sciences, 35(6), 843-852 (2010-12-09) Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells.Naoyuki Takayama et al.The Journal of toxicological sciences, 36(6), 817-821 (2011-12-02) Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity.Stefan Wirth et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 15(3), 429-440 (2010-01-22) 1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification.Akiko Endo et al.Biochemical and biophysical research communications, 361(1), 243-248 (2007-07-31) 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation.Daigo Sumi et al.The Journal of toxicological sciences, 35(6), 891-898 (2010-12-09) Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1,2-naphthoquinone protein adduct formation.Takashi Miura et al.Free radical biology & medicine, 51(11), 2082-2089 (2011-10-04) Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells.B Liu et al.Proceedings of the National Academy of Sciences of the United States of America, 97(18), 9855-9860 (2000-08-30) Efficient generation of ortho-naphthoquinone methides from 1,4-epoxy-1,4-dihydronaphthalenes and their annulation with allyl silanes.Yoshinari Sawama et al.Angewandte Chemie (International ed. in English), 52(5), 1515-1519 (2012-12-21) Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4.Takashi Toyama et al.Chemico-biological interactions, 214, 41-48 (2014-03-04) Novel spectrophotometric method for determination of some macrolide antibiotics in pharmaceutical formulations using 1,2-naphthoquinone-4-sulphonate.Safwan Ashour et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 74-80 (2012-10-09) Naphthalene metabolism and growth inhibition by naphthalene in Polaromonas naphthalenivorans strain CJ2.Graham M Pumphrey et al.Microbiology (Reading, England), 153(Pt 11), 3730-3738 (2007-11-03) 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.Shota Kikuno et al.Toxicology and applied pharmacology, 210(1-2), 47-54 (2005-07-26) Structure-activity relationships in the haemolytic activity and nephrotoxicity of derivatives of 1,2- and 1,4-naphthoquinone.Rex Munday et al.Journal of applied toxicology : JAT, 27(3), 262-269 (2007-02-01) Effects of different quinoid redox mediators on the simultaneous removal of p-cresol and sulphide in a denitrifying process.Edna R Meza-Escalante et al.Water science and technology : a journal of the International Association on Water Pollution Research, 59(10), 1945-1950 (2009-05-29) A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.Ashley A Reinke et al.Bioorganic & medicinal chemistry letters, 19(17), 4952-4957 (2009-07-31) 1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes.Robert F Jacob et al.Investigative ophthalmology & visual science, 54(12), 7189-7197 (2013-10-17) Inhibition of DNA binding activity of cAMP response element-binding protein by 1,2-naphthoquinone through chemical modification of Cys-286.Akiko Endo et al.Chemico-biological interactions, 192(3), 272-277 (2011-05-03) Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions.Hsueh-Cheng Chiang et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1969-1977 (2009-03-04) Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling.Yasuhiro Shinkai et al.Chemical research in toxicology, 25(6), 1222-1230 (2012-05-17) Rethinking Dithiothreitol-Based Particulate Matter Oxidative Potential: Measuring Dithiothreitol Consumption versus Reactive Oxygen Species Generation.Qianshan Xiong et al.Environmental science & technology, 51(11), 6507-6514 (2017-05-11) Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats.Suramya Waidyanatha et al.Chemico-biological interactions, 141(3), 189-210 (2002-10-19)

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