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Peer-Reviewed Papers

Biotransformation of extracted digitoxin from Digitalis lanata by Streptomyces.S Keshk et al.Die Pharmazie, 66(6), 458-462 (2011-06-28) Analysis of glipizide binding to normal and glycated human serum albumin by high-performance affinity chromatography.Ryan Matsuda et al.Analytical and bioanalytical chemistry, 407(18), 5309-5321 (2015-04-29) Influence of protein conformation and selected Hofmeister salts on bovine serum albumin/lutein complex formation.Paulo Henrique C Paiva et al.Food chemistry, 305, 125463-125463 (2019-09-15) A stereoselective synthesis of digitoxin and digitoxigen mono-and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylationZhou M and George AO Experimental Hematology & Oncology, 8(19), 4339-4342 (2006) Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.Kaori Okuyama-Dobashi et al.Scientific reports, 5, 17047-17047 (2015-11-26) [Digitoxin overdose with reversible thrombocytopenia].K G Dahmen et al.Medizinische Klinik (Munich, Germany : 1983), 91(12), 791-795 (1996-12-15) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Lourdes Santana et al.Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07) [Rational and safe pharmacotherapy for the aged].Camilla Bystad et al.Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(3), 268-268 (2013-02-06) Binding of caffeic acid to human serum albumin by the retention data and frontal analysis.Yuxin An et al.Biomedical chromatography : BMC, 28(12), 1881-1886 (2014-05-16) Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.Hsiang-Ting Ho et al.The Journal of physiology, 589(Pt 19), 4697-4708 (2011-08-03) Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis.Cheng-Wei Yang et al.Biochemical pharmacology, 180, 114122-114122 (2020-06-28) Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved.Miguel López-Lázaro Expert opinion on therapeutic targets, 11(8), 1043-1053 (2007-08-02) Study of fluorescence interaction and conformational changes of bovine serum albumin with histamine H₁ -receptor--drug epinastine hydrochloride by spectroscopic and time-resolved fluorescence methods.Girish G Ariga et al.Biopolymers, 103(11), 646-657 (2015-07-29) Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.R Scott Obach et al.Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23) The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B.Erik S Anderson et al.RNA (New York, N.Y.), 18(5), 1041-1049 (2012-03-30) The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin.Maoquan Zhou et al.Current topics in medicinal chemistry, 8(2), 114-125 (2008-02-22) Ex vivo activity of cardiac glycosides in acute leukaemia.Helene Hallböök et al.PloS one, 6(1), e15718-e15718 (2011-01-20) Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides.Simon C Groen et al.Insect biochemistry and molecular biology, 81, 51-61 (2016-12-25) The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner.Camilla Schinner et al.Basic research in cardiology, 115(4), 46-46 (2020-06-20) Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.Miguel López-Lázaro et al.Journal of natural products, 68(11), 1642-1645 (2005-11-29) Hologram QSAR model for the prediction of human oral bioavailability.Tiago L Moda et al.Bioorganic & medicinal chemistry, 15(24), 7738-7745 (2007-09-18) Plasma protein binding of digitoxin and some other drugs in renal disease.J J Lohman et al.Pharmaceutisch weekblad. Scientific edition, 9(2), 75-78 (1987-04-24) Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes.Peter Kolkhof et al.Biochemical and biophysical research communications, 394(1), 233-239 (2010-03-09) Biological activity of natural flavonoids as impacted by protein flexibility: an example of flavanones.Fei Ding et al.Molecular bioSystems, 11(4), 1119-1133 (2015-02-13) [Determination of digoxin and digitoxin in the blood and their clinical significance].G Bodem et al.Klinische Wochenschrift, 51(2), 57-62 (1973-01-15) Comparative interactions of dihydroquinazolin derivatives with human serum albumin observed via multiple spectroscopyWang Y, et al. Applied Sciences, 7(2), 200-200 (2017) Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine.Luigi M Castello et al.Biochemia medica, 22(3), 380-384 (2012-10-25) HPLC method validation for Digitalis and its analogue by pulsed amperometric detection.Ha-Jeong Kwon et al.Journal of pharmaceutical and biomedical analysis, 54(1), 217-221 (2010-08-31) [Digitoxin].K Yamamoto et al.Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 945-949 (1995-02-01) Cardiac glycosides decrease prostate specific antigen expression by down-regulation of prostate derived Ets factor.Horng-Heng Juang et al.The Journal of urology, 184(5), 2158-2164 (2010-09-21) Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.Arun Kapoor et al.Antimicrobial agents and chemotherapy, 56(9), 4891-4899 (2012-07-11) C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity.John W Hinds et al.ChemMedChem, 8(1), 63-69 (2012-11-10) Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.Jenny Felth et al.Journal of natural products, 72(11), 1969-1974 (2009-11-10) Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro.C I Delebinski et al.Cell proliferation, 48(5), 600-610 (2015-08-25) An elderly man with atrial fibrillation and exacerbated diabetes.Ketil Arne Espnes et al.Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 132(9), 1103-1105 (2012-05-23) Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates.Yuyong Ma et al.The Journal of organic chemistry, 76(23), 9748-9756 (2011-11-08) Thermodynamic and kinetic analyses of curcumin and bovine serum albumin binding.Eliara Acipreste Hudson et al.Food chemistry, 242, 505-512 (2017-10-19) Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks.Ioannis Prassas et al.Molecular cancer therapeutics, 10(11), 2083-2093 (2011-08-24) Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.Sihyung Yang et al.Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07) Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.Marie Jensen et al.Bioorganic & medicinal chemistry, 19(7), 2407-2417 (2011-03-23) Termination of refractory focal status epilepticus by the P-glycoprotein inhibitor verapamil.S Pirker et al.European journal of neurology, 18(12), e151-e151 (2011-11-22) Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification.Joseph M Langenhan et al.Journal of natural products, 68(11), 1696-1711 (2005-11-29) Digitalis therapy in renal failure with special regard to digitoxin.H F Vöhringer et al.International journal of clinical pharmacology, therapy, and toxicology, 19(4), 175-184 (1981-04-01) Analysis of drug interactions with modified proteins by high-performance affinity chromatography: binding of glibenclamide to normal and glycated human serum albumin.Ryan Matsuda et al.Journal of chromatography. A, 1265, 114-122 (2012-10-25) Exploring the interaction of the photodynamic therapeutic agent thionine with bovine serum albumin: multispectroscopic and molecular docking studies.Perumal Manivel et al.Luminescence : the journal of biological and chemical luminescence, 30(6), 729-739 (2014-11-27) [Changed digitalis dosing].Asmund Reikvam Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 130(13), 1324-1324 (2010-07-03) Treatment of congestive heart failure--current status of use of digitoxin.G G Belz et al.European journal of clinical investigation, 31 Suppl 2, 10-17 (2001-08-30) [Interaction of quinidine on the pharmacokinetics of digitoxin : a controversal view (author's transl)].M Lesne et al.Therapie, 36(6), 631-634 (1981-11-01) [EKG-changes with gastrointestinal disorder].H Boenigk et al.Deutsche medizinische Wochenschrift (1946), 136(20), 1053-1054 (2011-05-12) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Francisco J Prado-Prado et al.Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27) Digitoxin for airway inflammation in cystic fibrosis: preliminary assessment of safety, pharmacokinetics, and dose findingZeitlin PL, et al. Annals of the American Thoracic Society, 14(2), 220-229 (2017) Identification of anti-viral activity of the cardenolides, NaCheng-Wei Yang et al.Toxicology and applied pharmacology, 332, 129-137 (2017-04-26) Kinetics and thermodynamics of bovine serum albumin interactions with Congo red dye.Hauster Maximiler Campos de Paula et al.Colloids and surfaces. B, Biointerfaces, 159, 737-742 (2017-09-08) Analysis of multi-site drug-protein interactions by high-performance affinity chromatography: Binding by glimepiride to normal or glycated human serum albumin.Ryan Matsuda et al.Journal of chromatography. A, 1408, 133-144 (2015-07-21) Synthesis of cardiac glycoside analogs by catalyst-controlled, regioselective glycosylation of digitoxin.Thomas M Beale et al.Organic letters, 15(6), 1358-1361 (2013-03-08) Beneficial effect of digitoxin for heart failure from noncompaction in myotonic dystrophy 1.Josef Finsterer et al.International journal of cardiology, 160(3), e50-e51 (2012-04-06) [Personality disorders in late life: an overview].Naoki Hayashi Nihon rinsho. Japanese journal of clinical medicine, 71(10), 1823-1829 (2013-11-23) Digitalis and diabetes.Steinar Madsen Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 132(9), 1105-1105 (2012-05-23) [Do we still need digitalis today?].E Erdmann MMW Fortschritte der Medizin, 152(6), 18-18 (2010-03-23) Compound library screening identified cardiac glycoside digitoxin as an effective growth inhibitor of gefitinib-resistant non-small cell lung cancer via downregulation of ?-tubulin and inhibition of microtubule formationZhang YZ, et al. Molecules (Basel), 21(3), 374-374 (2016) Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virusYang CW, et al. Toxicology and Applied Pharmacology, 337, 129-137 (2017) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Digitoxin and its analogs as novel cancer therapeuticsElbaz HA, et al. Experimental Hematology & Oncology, 1(1), 4-4 (2012) Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells.Hosam A Elbaz et al.Toxicology and applied pharmacology, 258(1), 51-60 (2011-11-01) [Dosing of digitoxin in clinical practice].Arne Hønnås et al.Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 130(13), 1334-1336 (2010-07-03) Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.Jannette Gavillán-Suárez et al.BMC complementary and alternative medicine, 15, 244-244 (2015-07-23) Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.Bram Baert et al.Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11) Biointeractions of herbicide atrazine with human serum albumin: UV-Vis, fluorescence and circular dichroism approachesZhu M, et al. International Journal of Environmental Research and Public Health, 15(1), 116-116 (2018)

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