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Andrographolide | CAS:5508-58-7
Andrographolide
  • Name:Andrographolide
  • CAS:5508-58-7
  • Synonyms:
  • Molecular Formula:C20H30O5
  • Molecular Weight:350.45
  • EINESC:226-852-5

Description

Properties

Melting point 229-232 ºC
Specific optical rotation -126 º (c=1.5,HAc)

Safety

SDS/MSDS S22;S24/25

SDS

Source SDS/MSDS Samples
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Articles
Peer-Reviewed Papers
What do we really know about the health effects of natural sources of trans fatty acids?David J Baer The American journal of clinical nutrition, 95(2), 267-268 (2011-12-30) The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor-α and -γ in a rodent model of dyslipidemia and the metabolic syndrome.Ye Wang et al.Molecular nutrition & food research, 56(8), 1234-1246 (2012-06-21) Breed effect on quality veal production in mountain areas: emphasis on meat fatty acid composition.Noelia Aldai et al.Meat science, 92(4), 687-696 (2012-07-10) Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids.S J Liu et al.Journal of dairy science, 94(6), 2977-2985 (2011-05-25) Short communication: in vivo deposition of [1-13C]vaccenic acid and the product of its Δ9-desaturation, [1-13C]rumenic acid, in the body tissues of lactating goats fed oils.P G Toral et al.Journal of dairy science, 95(11), 6755-6759 (2012-09-11) Both Dietary Fatty Acids and Those Present in the Cecotrophs Contribute to the Distinctive Chemical Characteristics of New Zealand Rabbit Milk Fat.Claudia A Betancourt López et al.Lipids, 53(11-12), 1085-1096 (2019-02-11) Positional determination of the carbon-carbon double bonds in unsaturated fatty acids mediated by solvent plasmatization using LC-MS.Shigeo Takashima et al.Scientific reports, 10(1), 12988-12988 (2020-08-02) Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women.Emilie Lacroix et al.The American journal of clinical nutrition, 95(2), 318-325 (2011-12-30) The inclusion of fresh forage in the lactating buffalo diet affects fatty acid and sensory profile of mozzarella cheese.P Uzun et al.Journal of dairy science, 101(8), 6752-6761 (2018-05-29) Conjugated linoleic acid synthesis-related protein proteasome subunit α 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue.Y C Jin et al.Journal of dairy science, 95(8), 4286-4297 (2012-07-24) Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages.Natalie Fournier et al.Biochimica et biophysica acta, 1821(2), 303-312 (2011-11-15) Isomerization of vaccenic acid to cis and trans C18:1 isomers during biohydrogenation by rumen microbes.S Laverroux et al.Lipids, 46(9), 843-850 (2011-06-28) Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2.Shannon N Mostyn et al.ACS chemical neuroscience, 8(9), 1949-1959 (2017-06-03) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice.Sasmita Tripathy et al.Journal of lipid research, 54(1), 71-84 (2012-10-27) Adipose tissue trans-fatty acids and changes in body weight and waist circumference.Camilla P Hansen et al.The British journal of nutrition, 111(7), 1283-1291 (2013-11-30) Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry.Guangling Jiao et al.Marine drugs, 13(6), 3849-3876 (2015-06-23) Dietary supplementation of trans-11-vaccenic acid reduces adipocyte size but neither aggravates nor attenuates obesity-mediated metabolic abnormalities in fa/fa Zucker rats.Suresh K Mohankumar et al.The British journal of nutrition, 109(9), 1628-1636 (2012-08-24) Determination of elaidic and vaccenic acids in foods using GC×GC-FID and GC×GC-TOFMS.Jaeho Ha et al.Talanta, 85(1), 252-258 (2011-06-08) Vaccenic and elaidic acid equally esterify into triacylglycerols, but differently into phospholipids of fed rat liver cells.Zhen-Yu Du et al.Lipids, 46(7), 647-657 (2011-05-27) Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality.E Øie et al.Journal of internal medicine, 270(3), 263-272 (2011-04-07) Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies.Sarah K Gebauer et al.Advances in nutrition (Bethesda, Md.), 2(4), 332-354 (2012-02-15) Red blood cell trans-18:1 isomeric profile correlates with subcutaneous fat and muscle profiles in beef cattle.Noelia Aldai et al.Meat science, 91(2), 203-206 (2012-02-14) Fatty acid composition of ruminal bacteria and protozoa, and effect of defaunation on fatty acid profile in the rumen with special reference to conjugated linoleic acid in cattle.Halima Sultana et al.Animal science journal = Nihon chikusan Gakkaiho, 82(3), 434-440 (2011-05-28) Effect of the dietary supplementation of essential oils from rosemary and artemisia on muscle fatty acids and volatile compound profiles in Barbarine lambs.Valentina Vasta et al.Meat science, 95(2), 235-241 (2013-06-12) Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.Enrico Girardi et al.PLoS biology, 9(11), e1001189-e1001189 (2011-11-10) A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats.Arturo Anadon et al.Journal of agricultural and food chemistry, 59(14), 8036-8046 (2011-06-18) Ricinoleic acid inhibits methanogenesis and fatty acid biohydrogenation in ruminal digesta from sheep and in bacterial cultures.E Ramos Morales et al.Journal of animal science, 90(13), 4943-4950 (2012-07-26) Trans-palmitoleic acid (trans-9-C16:1, or trans-C16:1 n-7): Nutritional impacts, metabolism, origin, compositional data, analytical methods and chemical synthesis. A review.Etienne Guillocheau et al.Biochimie, 169, 144-160 (2019-12-15) Milk production and fatty acid profile of dairy cows grazing four grass species pastures during the rainy season in small-scale dairy systems in the highlands of Mexico.D A Plata-Reyes et al.Tropical animal health and production, 50(8), 1797-1805 (2018-06-28) Chemical identification of an aggregation pheromone in the termite Reticulitermes speratus.Yuki Mitaka et al.Scientific reports, 10(1), 7424-7424 (2020-05-06) Association of protein expression in isolated milk epithelial cells and cis-9, trans-11 conjugated linoleic acid proportions in milk from dairy cows.Wang T, Lim JN, Bok JD, et al. Journal of the Science of Food and Agriculture, 94(9), 1835-1843 (2014) Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men.Michael A Zulyniak et al.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 37(5), 1003-1007 (2012-06-23) Effect of tanniniferous Terminalia chebula extract on rumen biohydrogenation, ∆(9)-desaturase activity, CLA content and fatty acid composition in longissimus dorsi muscle of kids.Madhu Suman Rana et al.Meat science, 90(3), 558-563 (2011-10-25) Vaccenic acid-mediated reduction in cytokine production is independent of c9,t11-CLA in human peripheral blood mononuclear cells.Anke Jaudszus et al.Biochimica et biophysica acta, 1821(10), 1316-1322 (2012-07-04) Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic dermatitis in mice.X Sun et al.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 41(5), 729-738 (2011-03-25) Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro.Dan Li et al.BMC research notes, 5, 97-97 (2012-02-18)
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