Boiling point	259 ºC
Density	1.067
Refractive index	1.6125-1.6145

Symbol(GHS)	Xn
Hazard Codes	R22;R36/37/38;R68
SDS/MSDS	S26;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium.V Vlahov et al.European journal of clinical pharmacology, 38(1), 61-65 (1990-01-01) Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis.Y Matzner et al.European journal of clinical investigation, 14(6), 440-443 (1984-12-01) Plasma kinetics of dipyrone metabolites in rapid and slow acetylators.M Levy et al.European journal of clinical pharmacology, 27(4), 453-458 (1984-01-01) Simultaneous determination of aminopyrine hydroxylation and aminopyrine N-demethylation in liver microsomes by high-performance liquid chromatography.K Inoue et al.Journal of chromatography, 274, 201-208 (1983-05-13) High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes.G Geisslinger et al.Pharmaceutical research, 13(8), 1272-1275 (1996-08-01) Determination of antipyrine metabolites in human plasma by solid-phase extraction and micellar liquid chromatography.I Carretero et al.The Analyst, 120(6), 1729-1732 (1995-06-01) Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.M Levy et al.European journal of clinical pharmacology, 57(6-7), 461-465 (2001-11-09) [Metamizol--acute overdose with suicidal intent].H Wolhoff et al.Deutsche medizinische Wochenschrift (1946), 108(46), 1761-1764 (1983-11-18) Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone.O Cohen et al.European journal of clinical pharmacology, 54(7), 549-553 (1998-12-01) High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.Adriana Miriam Domínguez-Ramírez et al.Journal of pharmaceutical and biomedical analysis, 71, 173-178 (2012-08-25) Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites.M J D'Souza et al.Journal of chromatography, 421(1), 198-205 (1987-10-09) Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics.Y Caraco et al.Arzneimittel-Forschung, 43(11), 1204-1208 (1993-11-01) Formation and excretion of dipyrone metabolites in man.E Zylber-Katz et al.European journal of clinical pharmacology, 42(2), 187-191 (1992-01-01) Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.S Imaoka et al.Archives of biochemistry and biophysics, 265(1), 159-170 (1988-08-15) Integrating organic micropollutant removal into tertiary filtration: Combining PAC adsorption with advanced phosphorus removal.Altmann J, et al. Water Research, 84, 58-65 (2015) Plasma protein binding of dipyrone metabolites in man.E Zylber-Katz et al.European journal of clinical pharmacology, 29(1), 67-71 (1985-01-01) Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.María J Gómez et al.Water research, 42(10-11), 2698-2706 (2008-02-26) Multiresidue analysis of 88 polar organic micropollutants in ground, surface and wastewater using online mixed-bed multilayer solid-phase extraction coupled to high performance liquid chromatography-tandem mass spectrometry.Sebastian Huntscha et al.Journal of chromatography. A, 1268, 74-83 (2012-11-10) Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.C Herdeg et al.Liver, 22(6), 507-513 (2002-11-26) Multiresidue analytical method for the simultaneous determination of 72 micropollutants in aqueous samples with ultra high performance liquid chromatography-high resolution mass spectrometry.Wode F, et al. Journal of Chromatography A, 1270, 118-126 (2012) Influence of phenobarbital and 3-methylcholanthrene on the metabolism of aminopyrine in isolated hepatocyte system.K Matsuyama et al.Journal of pharmacobio-dynamics, 6(11), 821-828 (1983-11-01) Thin-layer chromatographic determination of major metamizole metabolites in serum and urine.N Sistovaris et al.Journal of chromatography, 274, 289-298 (1983-05-13)

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