Melting point	40-42 ºC**
Boiling point	151-152 ºC***
Flash point	30.0±0.0 ºC, 计算值****
Density	0.891 g/cm3 (20 ºC)*
Refractive index	1.48434 (589.3 nm 20 ºC)*

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Source	SDS/MSDS Samples
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Articles

Peer-Reviewed Papers

A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.Xinghan Li et al.BioMed research international, 2015, 197183-197183 (2015-02-20) Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.Nadeem Siddiqui et al.European journal of medicinal chemistry, 45(4), 1536-1543 (2010-02-02) Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives.Pierre Morieux et al.Bioorganic & medicinal chemistry, 16(19), 8968-8975 (2008-09-16) Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.Xian-Qing Deng et al.European journal of medicinal chemistry, 46(7), 2955-2963 (2011-05-04) Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.J J Rahn et al.Neuroscience, 259, 142-154 (2013-12-03) LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.Xiao-Jun Li et al.Proceedings of the National Academy of Sciences of the United States of America, 117(36), 22225-22236 (2020-08-23) Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5.Dong-Yun Ouyang et al.Autophagy, 9(1), 20-32 (2012-10-19) Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma.R B Erlich et al.British journal of cancer, 106(1), 107-115 (2011-11-26) Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.April Goehring et al.Nature protocols, 9(11), 2574-2585 (2014-10-10) Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N).Mazid Md Abdul et al.Stem cell research, 41, 101607-101607 (2019-11-30) Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.Clayton A White et al.Journal of immunology (Baltimore, Md. : 1950), 193(12), 5933-5950 (2014-11-14) Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine.Yifan Zhang et al.PloS one, 10(5), e0125898-e0125898 (2015-05-13) Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.Sushil K Kashaw et al.European journal of medicinal chemistry, 44(11), 4335-4343 (2009-08-14) Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism.N F M Olde Loohuis et al.Neurobiology of disease, 80, 42-53 (2015-05-20) D-Cycloserine ameliorates social alterations that result from prenatal exposure to valproic acid.Kristen A Wellmann et al.Brain research bulletin, 108, 1-9 (2014-08-19) RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study.Lijing Shen et al.BMC cancer, 15, 970-970 (2015-12-18) p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.A Jiemjit et al.Oncogene, 27(25), 3615-3623 (2008-01-29) Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells.Julia Biermann et al.Investigative ophthalmology & visual science, 51(1), 526-534 (2009-07-25) A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitorsRempel E, et al. Archives of Toxicology, 89(9), 1599-1618 (2015) Accuracy, discriminative properties and reliability of a human ESC-based in vitro toxicity assay to distinguish teratogens responsible for neural tube defects.Anne-Catherine Feutz et al.Archives of toxicology, 93(8), 2375-2384 (2019-08-12) SOX2 reprograms resident astrocytes into neural progenitors in the adult brain.Wenze Niu et al.Stem cell reports, 4(5), 780-794 (2015-04-30) A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention.Raghavender Medishetti et al.Journal of pharmacological and toxicological methods, 101, 106656-106656 (2019-11-18) Valproic acid antagonizes the capacity of other histone deacetylase inhibitors to activate the Epstein-barr virus lytic cycle.Derek Daigle et al.Journal of virology, 85(11), 5628-5643 (2011-03-18) A locust embryo as predictive developmental neurotoxicity testing system for pioneer axon pathway formation.Karsten Bode et al.Archives of toxicology, 94(12), 4099-4113 (2020-10-21) Valproic acid suppresses Warburg effect and tumor progression in neuroblastomaFang E, et al. Biochemical and Biophysical Research Communications (2018) Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells.Yusuke Marikawa et al.Reproductive toxicology (Elmsford, N.Y.), 91, 74-91 (2019-11-13) Epigenetic predisposition to reprogramming fates in somatic cells.Maayan Pour et al.EMBO reports, 16(3), 370-378 (2015-01-21) Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells.Shien Hu et al.Molecular cancer, 14, 180-180 (2015-10-16) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions.Shiping Zou et al.Journal of neurochemistry, 149(1), 98-110 (2019-01-24) Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers.Sebastian Bultmann et al.Nucleic acids research, 40(12), 5368-5377 (2012-03-06) Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors.Caroline E Hendry et al.Journal of the American Society of Nephrology : JASN, 24(9), 1424-1434 (2013-06-15) Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells.Jussi Ryynänen et al.PloS one, 8(10), e78170-e78170 (2013-11-20) Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes.M Y Follo et al.Leukemia, 25(2), 271-280 (2010-11-27) Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.Rafaela C Sartore et al.PloS one, 6(6), e20667-e20667 (2011-06-16) Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.Xiaotian T Fang et al.Biological procedures online, 19, 11-11 (2017-09-22) A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε.Deguang Liang et al.Cell research, 21(5), 793-806 (2011-01-12) Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells.Koji Yamanegi et al.International journal of oncology, 46(5), 1994-2002 (2015-03-18) The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices.Inge M Westra et al.PloS one, 9(4), e95462-e95462 (2014-04-24) Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice.B Pragnya et al.Behavioural brain research, 270, 86-94 (2014-05-08) Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR study.Saeed Emami et al.Bioorganic & medicinal chemistry letters, 21(2), 655-659 (2011-01-05) Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide.Osvaldo Garrido-Acosta et al.BioMed research international, 2016, 3978010-3978010 (2016-03-24) Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer.Ramchandra Vigay Amnekar et al.World journal of gastroenterology, 26(6), 598-613 (2020-02-28) Valproic acid overcomes hypoxia-induced resistance to apoptosis.Šimon Cipro et al.Oncology reports, 27(4), 1219-1226 (2011-12-14) Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes.Seiji Kuroda et al.Molecular therapy. 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Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring.Mingming Zhao et al.Journal of chromatographic science, 55(4), 436-444 (2016-12-21) Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties.Amber M King et al.Journal of medicinal chemistry, 54(19), 6417-6431 (2011-08-25) Disrupted Social Hierarchy in Prenatally Valproate-Exposed Autistic-Like Rats.Péter Pelsőczi et al.Frontiers in behavioral neuroscience, 13, 295-295 (2020-02-06) Anticonvulsant activity of some xanthone derivatives.Henryk Marona et al.Bioorganic & medicinal chemistry, 16(15), 7234-7244 (2008-07-22) Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.Stephen J Fey et al.Toxicological sciences : an 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