没有数据	没有数据

Symbol(GHS)	T+
Hazard Codes	R26/28
SDS/MSDS	S24;S45

Source	SDS/MSDS Samples
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Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1.S Ozawa et al.Xenobiotica; the fate of foreign compounds in biological systems, 30(10), 1005-1017 (2001-04-21) Sulfhydryl compounds inhibit the cyto- and geno-toxicity of o-phenylphenol metabolites in CHO-K1 cells.S Tayama et al.Mutation research, 259(1), 1-12 (1991-01-01) Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells.A C Lambert et al.Mutation research, 322(4), 243-256 (1994-10-01) Peroxidative activation of o-phenylhydroquinone leads to the formation of DNA adducts in HL-60 cells.E Horvath et al.Carcinogenesis, 13(10), 1937-1939 (1992-10-01) Metabolism of naphthalene by the biphenyl-degrading bacterium Pseudomonas paucimobilis Q1.A E Kuhm et al.Biodegradation, 2(2), 115-120 (1991-01-01) Orthophenylphenol and phenylhydroquinone residues in citrus fruit and processed citrus products after postharvest fungicidal treatments with sodium orthophenylphenate in California and Florida.G D Johnson et al.Journal of agricultural and food chemistry, 49(5), 2497-2502 (2001-05-23) The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix.T Okubo et al.Biological & pharmaceutical bulletin, 23(2), 199-203 (2000-03-08) Cytotoxic effects of biphenyl and hydroxybiphenyls on isolated rat hepatocytes.Y Nakagawa et al.Biochemical pharmacology, 45(10), 1959-1965 (1993-05-25) Ames test-negative carcinogen, ortho-phenyl phenol, binds tubulin and causes aneuploidy in budding yeast.Tatsuo Nunoshiba et al.Mutation research, 617(1-2), 90-97 (2007-02-10) Effects of pH on nonenzymatic oxidation of phenylhydroquinone: potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer 344 rats.E S Kwok et al.Chemical research in toxicology, 10(7), 742-749 (1997-07-01) Effects of diethyl maleate on phenyl-hydroquinone-induced cytotoxicity in isolated rat hepatocytes.Y Nakagawa et al.Xenobiotica; the fate of foreign compounds in biological systems, 23(2), 205-213 (1993-02-01) Effect of scavengers of active oxygen species on cell damage caused in CHO-K1 cells by phenylhydroquinone, an o-phenylphenol metabolite.S Tayama et al.Mutation research, 324(3), 121-131 (1994-07-01) Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.P Kolachana et al.Carcinogenesis, 12(1), 145-149 (1991-01-01) Metabolites of the biocide o-phenylphenol generate oxidative DNA lesions in V 79 cells.P Henschke et al.Archives of toxicology, 73(10-11), 607-610 (2000-02-09) Hydroxylation of biphenyl by the yeast Trichosporon mucoides.R Sietmann et al.Archives of microbiology, 174(5), 353-361 (2000-01-11) Inhibition of prostaglandin-H-synthase by o-phenylphenol and its metabolites.A Freyberger et al.Archives of toxicology, 72(10), 637-644 (1998-12-16) Oxidative damage to cellular and isolated DNA by metabolites of a fungicide ortho-phenylphenol.M Murata et al.Carcinogenesis, 20(5), 851-857 (1999-05-20) Synthesis and biological evaluation of a new series of phenylhydroquinone derivatives as inhibitors of EGF-R-associated PTK activity.M E Million et al.Anti-cancer drug design, 11(2), 129-153 (1996-03-01) Depigmenting action of phenylhydroquinone, an O-phenylphenol metabolite, on the skin of JY-4 black guinea-pigs.Kuniaki Tayama et al.Pigment cell research, 15(6), 447-453 (2002-11-28) Phenyl hydroquinone, an Ames test-negative carcinogen, induces Hog1-dependent stress response signaling.Ayumi Yamamoto et al.The FEBS journal, 275(22), 5733-5744 (2008-10-31) Induction of mitosis delay, apoptosis and aneuploidy in human cells by phenyl hydroquinone, an Ames test-negative carcinogen.Masaru Imai et al.Genes & genetic systems, 84(1), 73-79 (2009-05-08) DNA adduct formation by o-phenylphenol metabolite in vivo and in vitro.K Ushiyama et al.Carcinogenesis, 13(8), 1469-1473 (1992-08-01) Formation of 8-hydroxydeoxyguanosine in calf thymus DNA treated in vitro with phenylhydroquinone, the major metabolite of O-phenylphenol.F Nagai et al.Carcinogenesis, 16(4), 837-840 (1995-04-01) Tuning surface hydrophilicity/hydrophobicity of hydrocarbon proton exchange membranes (PEMs).Chenfeng He et al.Journal of colloid and interface science, 466, 168-177 (2016-01-02) Analysis of genotoxicity and the carcinogenic mode of action for ortho-phenylphenol.David Brusick Environmental and molecular mutagenesis, 45(5), 460-481 (2005-02-17) Cytotoxic effects of phenyl-hydroquinone and some hydroquinones on isolated rat hepatocytes.Y Nakagawa et al.Biochemical pharmacology, 44(6), 1059-1065 (1992-09-25) Induction of 8-hydroxy-2'-deoxyguanosine in CHO-K1 cells exposed to phenyl-hydroquinone, a metabolite of ortho-phenylphenol.Y Nakagawa et al.Cancer letters, 101(2), 227-232 (1996-03-29)

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