Melting point	220 ºC
Specific optical rotation	-14.75 º (c=10 2 N HCl)
Water Solubility	346 g/L (20 ºC)

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
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Synthetic Route

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Name	CAS
Lacosamide	175481-36-4	View

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Articles

Peer-Reviewed Papers

[Synthesis of diethyl N-[p-(methylamino)benzoyl]-L-glutamate].Chao Tian et al.Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 40(4), 443-445 (2008-08-05) [Excitatory amino acid antagonists and potentiation of cortical evoked potentials].O Nanka Sbornik lekarsky, 100(1), 53-56 (2000-06-22) [A phase study of the glutamate-dependent EEG effects in the alpha- and beta-frequency ranges during the acute and subchronic administration of piracetam to rats].G I Kovalev et al.Eksperimental'naia i klinicheskaia farmakologiia, 63(1), 3-6 (2000-04-14) Protease-catalyzed regioselective polymerization and copolymerization of glutamic acid diethyl ester.Hiroshi Uyama et al.Biomacromolecules, 3(2), 318-323 (2002-03-13) The WAG/Rij rat model for nonconvulsive absence epilepsy: involvement of nonNMDA receptors.B W Peeters et al.Brain research bulletin, 33(6), 709-713 (1994-01-01) Mass spectrometric and kinetic studies on slow progression of papain-catalyzed polymerization of L-glutamic acid diethyl ester.Asako Narai-Kanayama et al.Biochimica et biophysica acta, 1780(6), 881-891 (2008-04-15) Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.W C Wu et al.Journal of the autonomic nervous system, 67(3), 145-155 (1998-02-28) NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats.J Folbergrová Experimental neurology, 130(2), 344-350 (1994-12-01) Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.J Folbergrová Experimental neurology, 145(2 Pt 1), 442-450 (1997-06-01) Ultrasound induced formation of organogel from a glutamic dendronLi Y, et al. Tetrahedron, 63(31), 7468-7473 (2007) Interactions between NMDA and nonNMDA receptors in nonconvulsive epilepsy in the WAG/Rij inbred strain.B W Peeters et al.Brain research bulletin, 33(6), 715-718 (1994-01-01) Effects of L-glutamate, substance P and substance P(1-7) on cardiovascular regulation in the nucleus tractus solitarius.M E Hall et al.Regulatory peptides, 46(1-2), 102-109 (1993-07-02) [The corticostriatal mechanisms of behavior].N F Suvorov et al.Fiziologicheskii zhurnal imeni I.M. Sechenova, 81(12), 1-12 (1995-12-01) Effects of ketamine and L-glutamic acid diethyl ester on spatial and nonspatial learning tasks in rats.R Lalonde et al.Pharmacology, biochemistry, and behavior, 44(3), 539-545 (1993-03-01) N-methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre.P D Evans et al.The Journal of experimental biology, 173, 229-249 (1992-12-01) Antagonism of non-NMDA receptors in the dorsal periaqueductal grey induces anxiolytic effect in the elevated plus maze.M G Matheus et al.Psychopharmacology, 132(1), 14-18 (1997-07-01) Cholinergic and glutamatergic transmission in medial vestibular nucleus neurons responding to lateral roll tilt in rats.S Takeshita et al.Brain research, 840(1-2), 99-105 (1999-10-13) Neurotransmitters in the thalamus relaying visceral input to the insular cortex in the rat.F Barnabi et al.American journal of physiology. Regulatory, integrative and comparative physiology, 281(5), R1665-R1674 (2001-10-20) [Study of the role of different types of glutamate receptors in spatial memory in rats].V I Petrov et al.Biulleten' eksperimental'noi biologii i meditsiny, 113(6), 617-619 (1992-06-01) Endothelin-1 and endothelin-3 modulate dopaminergic neurons through different mechanisms.K Horie et al.Life sciences, 57(8), 735-741 (1995-01-01) Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats.T Kubo et al.Brain research, 616(1-2), 311-314 (1993-07-09) Rapid regioselective oligomerization of L-glutamic acid diethyl ester catalyzed by papainLi G, et al. Macromolecules, 39(23), 7915-7921 (2006) Primary neurotransmitters and regulatory substances onto vestibular nucleus neurons.M Sasa et al.Uchu Seibutsu Kagaku, 15(4), 371-374 (2002-07-09) Fast-acting excitatory amino acids are involved in the enhancement of the aversiveness of the electrical stimulation of the inferior colliculus by systemic injections of muscimol.Manoel Jorge Nobre et al.Life sciences, 71(25), 2961-2972 (2002-10-18) [The role of non-NMDA glutamate receptors in the EEG effects of chronic administration of noopept GVS-111 in awake rats].G I Kovalev et al.Eksperimental'naia i klinicheskaia farmakologiia, 65(6), 6-9 (2003-02-25) Inhibition of cocaine intoxication by excitatory amino acid receptor antagonists.R W Rockhold et al.Annals of the New York Academy of Sciences, 648, 335-337 (1992-05-11) Varying fish scale derived hydroxyapatite bound hybrid peptide nanofiber scaffolds for potential applications in periodontal tissue regeneration.Niyasha P Wijedasa et al.Materials science & engineering. C, Materials for biological applications, 109, 110540-110540 (2020-04-02) Self-assembled nanohelix from a bolaamphiphilic diacetylene via hydrogelation and selective responsiveness towards amino acids and nucleobases.Yan Meng et al.Nanoscale, 9(21), 7199-7206 (2017-05-18) Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.Paola Corona et al.European journal of medicinal chemistry, 43(1), 189-203 (2007-05-29)

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