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Peer-Reviewed Papers

Protective action of tetramethylpyrazine on the medulla oblongata in rats with chronic hypoxia.Yan Ding et al.Autonomic neuroscience : basic & clinical, 173(1-2), 45-52 (2012-12-12) Design, synthesis, and biological activities of novel Ligustrazine derivatives.Xian-Chao Cheng et al.Bioorganic & medicinal chemistry, 15(10), 3315-3320 (2007-03-27) Quantitation of alkylpyrazines in maple syrup, maple flavors and non-maple syrups.Akochi-KE, et al. Food Research International, 27(5), 451-457 (1994) Synthesis and biological evaluation of new ligustrazine derivatives as anti-tumor agents.Penglong Wang et al.Molecules (Basel, Switzerland), 17(5), 4972-4985 (2012-05-02) Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine.Li-Sheng Wang et al.The Journal of pharmacy and pharmacology, 64(11), 1688-1694 (2012-10-13) Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.Ling Guo et al.Molecules (Basel, Switzerland), 17(5), 5412-5421 (2012-05-10) Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents.Hongfei Chen et al.European journal of medicinal chemistry, 46(11), 5609-5615 (2011-10-14) [Study on preparation of ligustrazine ocular implant and correlation between in vivo and in vitro drug release].Jun-Hua Wei et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1160-1164 (2013-08-16) Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats.Li-Heng Guo et al.Chinese journal of integrative medicine, 18(8), 610-615 (2012-08-03) Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.Lei Lv et al.Annals of clinical and laboratory science, 42(2), 198-202 (2012-05-16) Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways.Feng Zhang et al.Toxicology and applied pharmacology, 265(1), 51-60 (2012-10-02) Steam volatile aroma constituents of roasted cocoa beans.Van Praag M, et al. Journal of Agricultural and Food Chemistry, 16(6), 1005-1008 (1968) [Protective effect of Ligustrazine preconditioning on hepatic energy metabolism in ischemia/reperfusion injury of rat].Zhu-Lin Luo et al.Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 43(4), 540-542 (2012-09-25) Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.Yi-Wen Zhang et al.Die Pharmazie, 69(7), 532-536 (2014-07-31) [Effects of tetramethylpyrazine on nitric oxide synthase activity and calcium ion concentration of skeletal muscle in hindlimb unloading rats].Xue Wu et al.Zhonghua yi xue za zhi, 92(29), 2075-2077 (2012-12-21) Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes.Uddipak Rai et al.Life sciences, 236, 116836-116836 (2019-09-08) The effect of ligustrazine on L-type calcium current, calcium transient and contractility in rabbit ventricular myocytes.Zhiqiang Ren et al.Journal of ethnopharmacology, 144(3), 555-561 (2012-10-13) Precursor supply strategy for tetramethylpyrazine production by bacillus subtilis on solid-state fermentation of wheat bran.Fei Hao et al.Applied biochemistry and biotechnology, 169(4), 1346-1352 (2013-01-12) Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.Keming Yu et al.Oncology reports, 28(3), 955-960 (2012-06-20) Characterization of Volatile Flavor Compounds in Chinese Rice Wine Fermented from Enzymatic Extruded Rice.Enbo Xu et al.Journal of food science, 80(7), C1476-C1489 (2015-06-20) Development of ligustrazine-loaded lipid emulsion: formulation optimization, characterization and biodistribution.Lijun Wei et al.International journal of pharmaceutics, 437(1-2), 203-212 (2012-09-05) A new ligustrazine derivative--pharmacokinetic evaluation and antitumor activity by suppression of NF-kappaB/p65 and COX-2 expression in S180 mice.Penglong Wang et al.Die Pharmazie, 68(9), 782-789 (2013-10-24) Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.Yewei Sun et al.Bioorganic & medicinal chemistry, 16(19), 8868-8874 (2008-09-16) Antiviral effects of the constituents derived from Chinese herb medicines on infectious bursal disease virus.Yaogui Sun et al.Pharmaceutical biology, 51(9), 1137-1143 (2013-04-24) Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain.Yu-Fang Leng et al.The American journal of Chinese medicine, 40(6), 1229-1239 (2012-12-12) [Protective effect of ligustrazine hydrochloride on homocysteine-injured ECV304 cells].Dongming Xu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(12), 1836-1839 (2012-09-25) Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.Xian-Chao Cheng et al.Bioorganic & medicinal chemistry, 17(8), 3018-3024 (2009-03-31) Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211.Donghui Xu et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(5), 2012-2021 (2018-09-24) [Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats].Hongbing Wang et al.Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 26(5), 597-600 (2012-06-19) Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation.Jian-Zhong Hu et al.Journal of the neurological sciences, 324(1-2), 94-99 (2012-11-13) Ligustrazine and the contractile properties of soleus muscle in hindlimb-unloaded rats.Siyuan Li et al.Aviation, space, and environmental medicine, 83(11), 1049-1054 (2012-11-20) Preparation of natural borneol/2-hydroxypropyl-β-cyclodextrin inclusion complex and its effect on the absorption of tetramethylpyrazine phosphate in mouse.Jianyu Su et al.Chemical & pharmaceutical bulletin, 60(6), 736-742 (2012-06-13) Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats.Tsung-Kuei Kao et al.Experimental neurology, 247, 188-201 (2013-05-07) Tetramethylpyrazine upregulates the aquaporin 8 expression of hepatocellular mitochondria in septic rats.Jin-quan Wang et al.The Journal of surgical research, 185(1), 286-293 (2013-07-09) [Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].Binbin Feng et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(9), 1311-1314 (2012-07-19) [Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].Ling-tao Ding et al.Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 28(3), 170-172 (2012-09-13) Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.Qiqiang Tang et al.Brain research, 1488, 81-91 (2012-10-16) Protective action of tetramethylpyrazine on the medulla oblongata in rats with chronic hypoxia.Yan Ding et al.Autonomic neuroscience : basic & clinical, 173(1-2), 45-52 (2012-12-12) [Effects of combination of Salvia and Ligustrazine on TNF-α and TGF-β1 in serum and BALF of rats with pulmonary fibrosis].Chengliang Huang et al.Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(7), 673-676 (2013-07-11) Ligustrazine derivatives. Part 6: design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents.Zhenyu Li et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 8(5), 928-933 (2012-06-30)

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