Melting point	-5.5 ºC
Boiling point	75-76 ºC
Density	1.277
Refractive index	1.413-1.415

Symbol(GHS)	F;Xi
Hazard Codes	R11;R36/37/38
SDS/MSDS	S16;S29;S33;S7

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

The effect to IL-3Ralpha, downstream PI3k/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells.Ping Chen et al.Die Pharmazie, 69(4), 297-300 (2014-05-06) PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.Akio Iwanami et al.Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4339-4344 (2013-02-27) Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin-proteasome system in human sarcoma cells.Hui-Wen Chiu et al.Cancer letters, 356(2 Pt B), 762-772 (2014-12-03) Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.Xiao-Hui Zhang et al.Leukemia research, 37(12), 1719-1725 (2013-11-12) Genistein ameliorates adverse cardiac effects induced by arsenic trioxide through preventing cardiomyocytes apoptosis.Yuhua Fan et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31(1), 80-91 (2013-02-01) Down-regulation of signal transducer and activator of transcription 3 improves human acute myeloid leukemia-derived dendritic cell function.Michael T Brady et al.Leukemia research, 37(7), 822-828 (2013-05-01) Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a.Y Zhang et al.Neoplasma, 60(3), 247-253 (2013-02-05) Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491.Xingxing Wang et al.Toxicology letters, 227(2), 75-83 (2014-04-01) Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells.Yanfei Jia et al.PloS one, 8(1), e54774-e54774 (2013-02-06) Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.Adeline Vitaliano-Prunier et al.Blood, 124(25), 3772-3780 (2014-09-27) Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.Mayumi Watanabe et al.Toxicology, 322, 43-50 (2014-05-08) BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL.Davood Bashash et al.Anti-cancer agents in medicinal chemistry, 13(7), 1115-1125 (2013-01-09) Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway.Jianing Wu et al.Toxicology letters, 220(1), 61-69 (2013-04-02) A case report of acute myeloid leukemia after liver transplantation.Mingjuan Liu et al.Acta haematologica, 129(4), 225-228 (2013-01-09) The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma.Michael Karsy et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(5), 4567-4580 (2014-01-09) Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.Min You et al.The Journal of thoracic and cardiovascular surgery, 147(1), 508-516 (2013-10-08) Arsenic trioxide during consolidation for patients with previously untreated low/intermediate risk acute promyelocytic leukaemia may eliminate the need for maintenance therapy.Steven E Coutre et al.British journal of haematology, 165(4), 497-503 (2014-02-18) Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo.Richard W Ahn et al.PloS one, 8(3), e58491-e58491 (2013-03-26) Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib.M Huang et al.Leukemia, 27(10), 1970-1980 (2013-07-24) Arsenic trioxide: marked suppression of tumor metastasis potential by inhibiting the transcription factor Twist in vivo and in vitro.Guang-Zhi Wang et al.Journal of cancer research and clinical oncology, 140(7), 1125-1136 (2014-04-24) Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.Ritesh K Srivastava et al.Toxicology and applied pharmacology, 272(3), 879-887 (2013-08-21) Evaluation of multiple myeloma cell apoptosis in primary bone marrow samples.Katarina Rebersek et al.Clinical laboratory, 59(3-4), 389-395 (2013-06-04) Arsenic trioxide inhibits DNA methyltransferase and restores TMS1 gene expression in K562 cells.Hongli Li et al.Acta haematologica, 133(1), 18-25 (2014-07-06) Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis.Ali Zekri et al.Molecular and cellular endocrinology, 377(1-2), 84-92 (2013-07-16) Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma.Samriti Dogra et al.Cancer letters, 356(2 Pt B), 953-961 (2014-12-03) Characteristics and prognosis analysis of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide as the front-line therapy.Yinjun Lou et al.Leukemia research, 37(11), 1451-1456 (2013-08-21) Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.Kerl K, Moreno N, Holsten T, et al. International Journal of Cancer. Journal International Du Cancer, 135(4), 989-995 (2014) Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine.Victoria Cavaliere et al.European journal of cancer (Oxford, England : 1990), 50(18), 3243-3261 (2014-12-03) Determination of arsenic metabolites in patients with newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide.Zhuo Zhang et al.Leukemia & lymphoma, 54(9), 2041-2046 (2013-01-25) Arsenic trioxide stabilizes accumulations of adeno-associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo.Angela M Mitchell et al.Journal of virology, 87(8), 4571-4583 (2013-02-15) Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway.Lan Chen et al.Die Pharmazie, 68(2), 117-123 (2013-03-09) The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.W-C Yang et al.Oncogene, 32(43), 5167-5175 (2012-12-05) The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies.K L Rice et al.Journal of internal medicine, 276(1), 61-70 (2014-03-19) Enhanced cell growth and tumorigenicity of rat glioma cells by stable expression of human CD133 through multiple molecular actions.Kuan-Min Fang et al.Glia, 61(9), 1402-1417 (2013-07-09) Hepatotoxicity from arsenic trioxide for pediatric acute promyelocytic leukemia.Liangchun Hao et al.Journal of pediatric hematology/oncology, 35(2), e67-e70 (2013-02-16) Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization.Xiao Liu et al.Science China. Life sciences, 63(11), 1744-1754 (2020-05-10) Arsenic downregulates gene expression at the postsynaptic density in mouse cerebellum, including genes responsible for long-term potentiation and depression.Cong Zhang et al.Toxicology letters, 228(3), 260-269 (2014-05-17) Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic.Youhong Liu et al.Molecular carcinogenesis, 53(5), 380-391 (2012-12-21) Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?Valérie Lallemand-Breitenbach et al.Blood, 122(12), 2008-2010 (2013-07-31) SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic trioxide.Sneha Singh et al.Biochimica et biophysica acta, 1833(10), 2357-2368 (2013-06-19) Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.George Zhu et al.Current pharmaceutical biotechnology, 14(9), 849-858 (2014-01-18) How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia.Miguel A Sanz et al.Blood, 123(18), 2777-2782 (2014-03-15) Management of elderly patients with acute promyelocytic leukemia: progress and problems.Eva Lengfelder et al.Annals of hematology, 92(9), 1181-1188 (2013-05-23) Identification of recurrent SMO and BRAF mutations in ameloblastomas.Robert T Sweeney et al.Nature genetics, 46(7), 722-725 (2014-05-27) Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human.Yu-Hsun Lo et al.Blood, 121(16), 3185-3194 (2013-02-23) Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97.Hiroyuki Fujita et al.Cancer science, 104(10), 1339-1345 (2013-07-11) Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial.Hong-Hu Zhu et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(33), 4215-4221 (2013-10-16) The synergistic antitumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway.Hui Qu et al.Die Pharmazie, 68(10), 839-845 (2013-11-28) Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway.Joanna Roszak et al.Chemico-biological interactions, 205(3), 198-211 (2013-08-06) Arsenic trioxide induces cardiac fibroblast apoptosis in vitro and in vivo by up-regulating TGF-β1 expression.Cui Li et al.Toxicology letters, 219(3), 223-230 (2013-04-02) Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction.Sung-Keum Seo et al.Biochemical and biophysical research communications, 449(4), 490-495 (2014-05-23) Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha.Rabab M El Eit et al.International journal of cancer, 134(4), 988-996 (2013-08-13) Arsenic speciation in saliva of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.Baowei Chen et al.Analytical and bioanalytical chemistry, 405(6), 1903-1911 (2013-01-16) Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest.Saeed Hassani et al.Annals of hematology, 92(9), 1207-1220 (2013-05-07) Targeting agents alone to cure acute promyelocytic leukemia.Sai-Juan Chen et al.The New England journal of medicine, 369(2), 186-187 (2013-07-12) Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide.Ling-Huei Yih et al.Toxicology and applied pharmacology, 267(3), 228-237 (2013-01-29) Resistance to arsenic therapy in acute promyelocytic leukemia.Hong-Hu Zhu et al.The New England journal of medicine, 370(19), 1864-1866 (2014-05-09) Exposure of hepatocellular carcinoma cells to low-level As₂O₃‎ causes an extra toxicity pathway via L1 retrotransposition ‎induction.Abbas Karimi et al.Toxicology letters, 229(1), 111-117 (2014-06-25) A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma.Lauren A Held et al.Cancer investigation, 31(3), 172-176 (2013-02-15) Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.Guilherme Augusto Dos Santos et al.The Journal of experimental medicine, 210(13), 2793-2802 (2013-12-18) Tetrandrine enhances the anticancer effects of arsenic trioxide in vitro.Youran Chen et al.International journal of clinical pharmacology and therapeutics, 52(5), 416-424 (2014-02-20) The novel arsenical darinaparsin is transported by cystine importing systems.Nicolas Garnier et al.Molecular pharmacology, 85(4), 576-585 (2014-01-17) Arsenic trioxide treatment of rabbit liver VX-2 carcinoma via hepatic arterial cannulation-induced apoptosis and decreased levels of survivin in the tumor tissue.Hong Li et al.Croatian medical journal, 54(1), 12-16 (2013-02-28) Mees lines and Beau lines.Gregory Chesnut et al.Cutis, 91(3), 147-147 (2013-04-27) Identifying arsenic trioxide (ATO) functions in leukemia cells by using time series gene expression profiles.Hong Yang et al.Gene, 535(2), 312-317 (2013-11-23) Arsenic: an old enemy now turned friend.Frank Firkin et al.Leukemia & lymphoma, 54(9), 1864-1866 (2013-04-05) The evolving use of arsenic in pharmacotherapy of malignant disease.Athena Kritharis et al.Annals of hematology, 92(6), 719-730 (2013-03-16) Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway.Yu-Chen Hu et al.Biochemical pharmacology, 85(7), 1018-1026 (2013-01-23) Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer.Hui Ji et al.Cancer science, 105(12), 1541-1549 (2014-10-07) Outcomes and prognostic factors of first relapsed acute promyelocytic leukemia patients undergoing salvage therapy with intravenous arsenic trioxide and chemotherapy.Yinjun Lou et al.Annals of hematology, 93(6), 941-948 (2014-01-11) Src family kinase inhibitor PP2 enhances differentiation of acute promyelocytic leukemia cell line induced by combination of all-trans-retinoic acid and arsenic trioxide.Yun Seok Jung et al.Leukemia research, 38(8), 977-982 (2014-06-24) Arsenic methylation metabolism and liver injury of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.Huihui Wang et al.Environmental toxicology, 28(5), 267-275 (2013-04-17) Myocardial toxicity of acute promyelocytic leukaemia drug-arsenic trioxide.V V Mathews et al.European review for medical and pharmacological sciences, 17 Suppl 1, 34-38 (2013-04-26) Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.Francesco Lo-Coco et al.The New England journal of medicine, 369(2), 111-121 (2013-07-12) Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids.Monika Primon et al.Experimental cell research, 319(17), 2637-2648 (2013-08-24) Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia.Masamitsu Yanada et al.Blood, 121(16), 3095-3102 (2013-02-16)

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