Melting point	34-37 ºC
Water Solubility	slightly soluble
Flash point	91 ºC

Symbol(GHS)	Xn
Hazard Codes	R20/21/22;R36/37/38
SDS/MSDS	S26;S36/37/39

Source	SDS/MSDS Samples
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Articles

Peer-Reviewed Papers

Prolonging the postcomplex spike pause speeds eyeblink conditioning.Jaione Maiz et al.Proceedings of the National Academy of Sciences of the United States of America, 109(41), 16726-16730 (2012-09-19) Activity-dependent differences in function between proximal and distal Schaffer collaterals.Benjamin Owen et al.Journal of neurophysiology, 113(10), 3646-3662 (2015-04-10) Non-Canonical Control of Neuronal Energy Status by the Na+ Pump.Felipe Baeza-Lehnert et al.Cell metabolism, 29(3), 668-680 (2018-12-12) PACAP modulation of calcium ion activity in developing granule cells of the neonatal mouse olfactory bulb.Mavis Irwin et al.Journal of neurophysiology, 113(4), 1234-1248 (2014-12-06) Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats.Bao Fu et al.BMC anesthesiology, 17(1), 111-111 (2017-08-25) High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.Kelli Solly et al.Journal of biomolecular screening, 20(6), 708-719 (2015-02-24) Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.Marco Pignatelli et al.Neuron, 93(2), 425-440 (2017-01-20) The development of synaptic transmission is time-locked to early social behaviors in rats.Shovan Naskar et al.Nature communications, 10(1), 1195-1195 (2019-03-15) Ca2+-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse.Joy Y Sebe et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(25), 6162-6175 (2017-05-26) The post-synaptic scaffolding protein tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors.Saurabh Pandey et al.The Journal of biological chemistry, 295(25), 8575-8588 (2020-05-08) A novel functionally distinct subtype of striatal neuropeptide Y interneuron.Osvaldo Ibáñez-Sandoval et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16757-16769 (2011-11-18) Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury.Ying Li et al.Neurobiology of disease, 74, 240-253 (2014-12-17) Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.Wei Xu et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5867-5877 (2013-03-29) Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine.Rogier B Poorthuis et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4843-4853 (2013-03-15) Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex.Tingting Liu et al.Journal of neurophysiology, 111(11), 2287-2297 (2014-03-14) Focal activation of neuronal circuits induced by microstimulation in the visual cortexTanaka Y, et al. Journal of Neural Engineering, 16(3), 036007-036007 (2019) Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.Marco I González et al.Neurobiology of disease, 77, 246-256 (2015-03-15) Desire or Dread from Nucleus Accumbens Inhibitions: Reversed by Same-Site Optogenetic Excitations.Hannah M Baumgartner et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(13), 2737-2752 (2020-02-23) Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus.Hila Milshtein-Parush et al.Cerebral cortex (New York, N.Y. : 1991), 27(6), 3457-3470 (2017-04-14) Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin.Cyril G Eleftheriou et al.Molecular vision, 23, 334-345 (2017-07-01) Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia.Thomas Marissal et al.Nature neuroscience, 21(10), 1412-1420 (2018-09-19) Serotonin modulates glutamatergic transmission to neurons in the lateral habenula.Guiqin Xie et al.Scientific reports, 6, 23798-23798 (2016-04-02) Theoretical and Experimental Investigation of Acidity of the Glutamate Receptor Antagonist 6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione and Its Possible Implication in GluA2 Binding.Gutto R S de Freitas et al.The journal of physical chemistry. A, 121(39), 7414-7423 (2017-09-14) Fixed single-cell transcriptomic characterization of human radial glial diversity.Elliot R Thomsen et al.Nature methods, 13(1), 87-93 (2015-11-03) Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.Tharkika Nagendran et al.Nature communications, 8(1), 625-625 (2017-09-22) Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.Tongfei A Wang et al.Neuron, 103(2), 309-322 (2019-06-04) Excitatory amino acid receptors in the vertebrate central nervous system.G L Collingridge et al.Pharmacological reviews, 41(2), 143-210 (1989-06-01) Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala.Yanfang Zhao et al.BMC biology, 15(1), 128-128 (2017-12-29) Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice.Julia Leschik et al.Molecular neurobiology, 56(10), 6833-6855 (2019-04-01) Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit.Paul G Morris et al.Frontiers in cellular neuroscience, 12, 354-354 (2018-10-27) Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1.Vedakumar Tatavarty et al.Neuron, 106(5), 769-777 (2020-03-22) Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI.Phillip L W Colmers et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(49), 10444-10453 (2018-10-26) Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.Ji Hoon Yoo et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(1), 38-46 (2017-01-06) Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices.B E Lindquist et al.Neuroscience, 223, 365-376 (2012-08-07) Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex.Julian M C Choy et al.Cerebral cortex (New York, N.Y. : 1991), 27(1), 589-601 (2015-10-28) Concentration-dependent activation of dopamine receptors differentially modulates GABA release onto orexin neurons.Victoria Linehan et al.The European journal of neuroscience, 42(3), 1976-1983 (2015-06-04) Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus.Tingting Liu et al.Journal of neurophysiology, 113(7), 2646-2652 (2015-02-06) Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation.Aurore Thomazeau et al.Cerebral cortex (New York, N.Y. : 1991), 27(4), 2571-2579 (2016-03-08) High frequency stimulation-induced plasticity in the prelimbic cortex of rats emerges during adolescent development and is associated with an increase in dopamine receptor function.Shuo Kang et al.Neuropharmacology, 141, 158-166 (2018-08-31) Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation.Masaaki Kuwajima et al.PloS one, 15(1), e0226797-e0226797 (2020-01-16) A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus.Chung Sub Kim et al.Journal of neurophysiology, 113(7), 2511-2523 (2015-02-06) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.Ryan D Morrie et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(25), 9281-9286 (2015-06-26) Ni(2+)-sensitive T-type Ca(2+) channel currents are regulated in parallel with synaptic and visual response plasticity in visual cortex.Shoko Horibe et al.Neuroscience research, 87, 33-39 (2014-07-16) Transient Hearing Loss Within a Critical Period Causes Persistent Changes to Cellular Properties in Adult Auditory Cortex.Todd M Mowery et al.Cerebral cortex (New York, N.Y. : 1991), 25(8), 2083-2094 (2014-02-21) Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum.Rachel M Gwynne et al.Frontiers in physiology, 8, 991-991 (2017-12-20) Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels.Wanhong Zuo et al.Neuropharmacology, 101, 449-459 (2015-10-17) Paraventricular hypothalamic and amygdalar CRF neurons synapse in the external globus pallidus.Albert J Hunt et al.Brain structure & function, 223(6), 2685-2698 (2018-03-24) Dorsal raphe serotonin neurons in mice: immature hyperexcitability transitions to adult state during first three postnatal weeks suggesting sensitive period for environmental perturbation.Benjamin D Rood et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4809-4821 (2014-04-04) Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.Qin Yang et al.EBioMedicine, 47, 470-483 (2019-09-03) Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex.Dania Vecchia et al.Current biology : CB, 30(9), 1589-1599 (2020-03-15) IGF-1-Involved Negative Feedback of NR2B NMDA Subunits Protects Cultured Hippocampal Neurons Against NMDA-Induced Excitotoxicity.Yun Li et al.Molecular neurobiology, 54(1), 684-696 (2016-01-14) Contributions of quisqualate and NMDA receptors to the induction and expression of LTP.D Muller et al.Science (New York, N.Y.), 242(4886), 1694-1697 (1988-12-23) Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling.Luan Pereira Diniz et al.Glia, 62(12), 1917-1931 (2014-07-22) The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.Rei Yamada et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01) In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.Shinji Matsumura et al.The European journal of neuroscience, 41(7), 989-997 (2015-02-04) Focal activation of neuronal circuits induced by microstimulation in the visual cortex.Yuta Tanaka et al.Journal of neural engineering, 16(3), 036007-036007 (2019-03-01) Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity.Philip D Fox et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(36), 8667-8677 (2017-08-20) Short-term inhibition of GABAergic IPSCs induced by association of pre- and postsynaptic activation in the neonatal hippocampus.Megumi Taketo et al.Neuropharmacology, 121, 39-48 (2017-04-19) µ-Opioid receptor-induced synaptic plasticity in dopamine neurons mediates the rewarding properties of anabolic androgenic steroids.Leonardo Bontempi et al.Science signaling, 13(647) (2020-09-03) Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex.Moritz Armbruster et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(40), 10404-10415 (2016-10-07) Alterations in Properties of Glutamatergic Transmission in the Temporal Cortex and Hippocampus Following Pilocarpine-Induced Acute Seizures in Wistar Rats.Dmitry V Amakhin et al.Frontiers in cellular neuroscience, 11, 264-264 (2017-09-16) Glutamate: Where does it come from and where does it go?Grethe M Olsen et al.Neurochemistry international, 88, 47-52 (2014-12-03) Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells.Caifeng Shao et al.Biochemical and biophysical research communications, 522(4), 1059-1062 (2019-12-11) Inflammatory demyelination alters subcortical visual circuits.Sheila Espírito Santo Araújo et al.Journal of neuroinflammation, 14(1), 162-162 (2017-08-20) Modulatory Effects of Perineuronal Oligodendrocytes on Neuronal Activity in the Rat Hippocampus.Yoshihiko Yamazaki et al.Neurochemical research, 43(1), 18-31 (2017-04-27) The Glycolytic Metabolite, Fructose-1,6-bisphosphate, Blocks Epileptiform Bursts by Attenuating Voltage-Activated Calcium Currents in Hippocampal Slices.Li-Rong Shao et al.Frontiers in cellular neuroscience, 12, 168-168 (2018-07-03) Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.Juan D Pita-Almenar et al.Learning & memory (Cold Spring Harbor, N.Y.), 19(12), 615-626 (2012-11-21) Immediate Effects of Repetitive Magnetic Stimulation on Single Cortical Pyramidal Neurons.Jineta Banerjee et al.PloS one, 12(1), e0170528-e0170528 (2017-01-24) The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity.Xavier De Jaeger et al.Psychopharmacology, 225(3), 687-695 (2012-09-14) Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement.Ji Hoon Yoo et al.Nature communications, 7, 13697-13697 (2016-12-16) Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons.A R Wild et al.The European journal of neuroscience, 42(9), 2633-2643 (2015-09-16) Periaqueductal gray glutamatergic, cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation.Franklin P Back et al.Neuropharmacology, 135, 399-411 (2018-03-30) Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval.Mei-Mei Shi et al.Molecular psychiatry, 25(5), 977-992 (2019-05-31) Sexual dimorphism, estrous cycle and laterality determine the intrinsic and synaptic properties of medial amygdala neurons in rat.Francine Dalpian et al.Journal of cell science, 132(9) (2019-04-11) Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.David M Dorris et al.Journal of neurophysiology, 113(3), 720-729 (2014-11-08) Expression and functional roles of Kv7/KCNQ/M-channels in rat medial entorhinal cortex layer II stellate cells.Maximiliano Jose Nigro et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 6807-6812 (2014-05-16) Enhanced lateral inhibition in the barrel cortex by deletion of phospholipase C-related catalytically inactive protein-1/2 in mice.Hiroki Toyoda et al.Pflugers Archiv : European journal of physiology, 467(7), 1445-1456 (2014-08-29) Innermost desires.Elie Dolgin Nature medicine, 18(5), 644-644 (2012-05-09) ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines.Shu-Xia Cao et al.eLife, 7 (2018-09-05) Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Xiao-Jie Cao et al.Hearing research, 345, 57-68 (2017-01-10) Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala.Maureen T Cruz et al.Frontiers in neuroscience, 4, 207-207 (2011-01-25) The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS.Javier H Jara et al.Frontiers in molecular neuroscience, 13, 73-73 (2020-06-09) Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex.Shangbin Chen et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(39), 13510-13519 (2012-09-28) Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.Mridu Kapur et al.Neuron, 108(1), 193-208 (2020-08-28) Optoactivation of parvalbumin neurons in the spinal dorsal horn evokes GABA release that is regulated by presynaptic GABAB receptors.Kun Yang et al.Neuroscience letters, 594, 55-59 (2015-03-31) Layer-specific cholinergic modulation of synaptic transmission in layer 2/3 pyramidal neurons of rat visual cortex.Kwang-Hyun Cho et al.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 23(5), 317-328 (2019-09-10) Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Dongxu Guan et al.Journal of neurophysiology, 120(2), 394-408 (2018-04-12) Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.Mohammed Al-Yaari et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(3), 619-631 (2019-11-16) A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex.Qingtao Sun et al.Nature neuroscience, 22(8), 1357-1370 (2019-07-10) Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.R Adron Harris et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1139-1155 (2016-12-18) Functional up-regulation of the M-current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneurons.Filippo Ghezzi et al.The Journal of physiology, 596(13), 2611-2629 (2018-05-08) The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.Nicholas A Courtney et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(22), 7645-7656 (2014-05-30) Re-Opening the Critical Window for Estrogen Therapy.Linda A Bean et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(49), 16077-16093 (2015-12-15) Time course of the dependence of associative memory retrieval on the entorhinal cortex.Xi Chen et al.Neurobiology of learning and memory, 116, 155-161 (2014-12-03) Age-dependent expression of Nav1.9 channels in medial prefrontal cortex pyramidal neurons in rats.Maciej Gawlak et al.Developmental neurobiology, 77(12), 1371-1384 (2017-09-16) Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS.Yuqin Men et al.Nature communications, 10(1), 4136-4136 (2019-09-14) Increased O-GlcNAcylation rapidly decreases GABAAR currents in hippocampus but depresses neuronal output.L T Stewart et al.Scientific reports, 10(1), 7494-7494 (2020-05-06) Proopiomelanocortin expression in both GABA and glutamate neurons.Shane T Hentges et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(43), 13684-13690 (2009-10-30) Differential Distribution of Ca2+ Channel Subtypes at Retinofugal Synapses.Gubbi Govindaiah et al.eNeuro, 7(6) (2020-10-25) A neural basis for antagonistic control of feeding and compulsive behaviors.Leandra R Mangieri et al.Nature communications, 9(1), 52-52 (2018-01-06) α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.Qihui Wu et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(26), 5080-5094 (2019-05-01) Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia.Kevin S Jones et al.PloS one, 9(10), e109303-e109303 (2014-10-08) Effects of acute and chronic nicotine on catecholamine neurons of the nucleus of the solitary tract.Stephen J Page et al.American journal of physiology. Regulatory, integrative and comparative physiology, 316(1), R38-R49 (2018-10-26) Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model.Karolina Kolodziejczyk et al.Neurobiology of disease, 86, 62-74 (2015-12-02) Amyloid Beta42 oligomers up-regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors.Andrea Marcantoni et al.The Journal of physiology, 598(11), 2183-2197 (2020-04-05) Sucrose-induced plasticity in the basolateral amygdala in a 'comfort' feeding paradigm.Amy E B Packard et al.Brain structure & function, 222(9), 4035-4050 (2017-06-10) Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors.A Sagarduy et al.Experimental neurology, 277, 35-45 (2015-12-22) Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.Masaru Ishibashi et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(39), 10097-10115 (2016-09-30) A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.Rohan Sharma et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(40), 8605-8620 (2018-08-26) Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via βKatarzyna Grzelka et al.Frontiers in cellular neuroscience, 11, 341-341 (2017-12-07) Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.Przemysław Kurowski et al.Frontiers in cellular neuroscience, 12, 93-93 (2018-05-10) GluN2B-containing N-methyl-D-aspartate receptors compensate for the inhibitory control of synaptic plasticity during the early critical period in the rat visual cortex.Changik Lee et al.Journal of neuroscience 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