Melting point	-44.5 ºC
Water Solubility	Insoluble
Boiling point	172-174 ºC
Flash point	55 ºC
Density	1.178
Refractive index	1.5205-1.5225

Symbol(GHS)	Xn
Hazard Codes	R10;R22;R36/37/38
SDS/MSDS	S16;S26;S37/39

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Role of the fused corrinoid/methyl transfer protein CmtA during CO-dependent growth of Methanosarcina acetivorans.Venkata R Vepachedu et al.Journal of bacteriology, 194(16), 4161-4168 (2012-05-29) Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes.C L Drennan et al.Current opinion in structural biology, 4(6), 919-929 (1994-12-01) Neuroprotective effect of ultra-high dose methylcobalamin in wobbler mouse model of amyotrophic lateral sclerosis.Ken Ikeda et al.Journal of the neurological sciences, 354(1-2), 70-74 (2015-05-20) Methylcobalamin--a form of vitamin B12 identified and characterised in Chlorella vulgaris.Anantharajappa Kumudha et al.Food chemistry, 170, 316-320 (2014-10-13) Methylcobalamin: a potential vitamin of pain killerZhang M, et al. Neural Plast. (2013) B12 trafficking in mammals: A for coenzyme escort service.Ruma Banerjee ACS chemical biology, 1(3), 149-159 (2006-12-14) A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.Jihoe Kim et al.The Journal of biological chemistry, 284(48), 33418-33424 (2009-10-06) Methylcobalamin attenuates the hypoxia/hypoglycemia- or glutamate-induced reduction in hippocampal fiber spikes in vitro.Y Yamamoto et al.European journal of pharmacology, 281(3), 335-340 (1995-08-15) Thin-layer chromatography combined with diode laser thermal vaporization inductively coupled plasma mass spectrometry.Antonín Bednařík et al.Journal of chromatography. A, 1364, 271-275 (2014-09-07) Hydroxocobalamin association during cell culture results in pink therapeutic proteins.Kenneth M Prentice et al.mAbs, 5(6), 974-981 (2013-08-09) Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes.Stéphane Pierre et al.Nature chemical biology, 8(12), 957-959 (2012-10-16) Cortical blindness caused by hypoxemia following an asthma attack.Tomoyuki Kunishige et al.Japanese journal of ophthalmology, 55(5), 588-590 (2011-07-01) In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea.Williard J Werner et al.Biochemistry, 50(42), 8986-8988 (2011-09-29) Structural basis of multifunctionality in a vitamin B12-processing enzyme.Markos Koutmos et al.The Journal of biological chemistry, 286(34), 29780-29787 (2011-06-24) Connection between multimetal(loid) methylation in methanoarchaea and central intermediates of methanogenesis.Frank Thomas et al.Applied and environmental microbiology, 77(24), 8669-8675 (2011-10-18) Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.Qian Xu et al.Diabetes research and clinical practice, 101(2), 99-105 (2013-05-15) Hyperintense signal on spinal cord diffusion-weighted imaging in a patient with subacute combined degeneration.Chenglin Tian Neurology India, 59(3), 429-431 (2011-07-12) L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.Andrew McCaddon et al.CNS spectrums, 15(1 Suppl 1), 2-5 (2010-04-20) B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes.John David Spence Clinical chemistry and laboratory medicine, 51(3), 633-637 (2013-03-02) Corrin ring-induced redox tuning.Manoj Kumar et al.Chemical communications (Cambridge, England), 48(37), 4456-4458 (2012-03-29) A case report of abdominal distention caused by herpes zoster.Su-Rong Zhou et al.World journal of gastroenterology, 18(33), 4627-4628 (2012-09-13) Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis.Ashit Syngle et al.International journal of rheumatic diseases, 15(1), 45-55 (2012-02-14) Cobalamin deficiency presenting as obsessive compulsive disorder: case report.Vivek Sharma et al.General hospital psychiatry, 34(5), 578-578 (2012-01-10) Environmental fate of the next generation refrigerant 2,3,3,3-tetrafluoropropene (HFO-1234yf).Jeongdae Im et al.Environmental science & technology, 48(22), 13181-13187 (2014-10-21) Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients.Hyoung-Il Kim et al.Annals of surgical oncology, 18(13), 3711-3717 (2011-05-11) [Clinical observation on diabetic peripheral neuropathy treated with electroacupuncture and acupoint injection].Ze Jin et al.Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 31(7), 613-616 (2011-08-10) Electronic structure of one-electron-oxidized form of the methylcobalamin cofactor: spin density distribution and pseudo-Jahn-teller effect.Neeraj Kumar et al.Inorganic chemistry, 52(4), 1762-1771 (2013-01-31) Adenosyltransferase: an enzyme and an escort for coenzyme B12?Mamoru Yamanishi et al.Trends in biochemical sciences, 30(6), 304-308 (2005-06-14) The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial.C K Chiu et al.Singapore medical journal, 52(12), 868-873 (2011-12-14) Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury modelOkada K, et al. Experimental Neurology, 222(2), 191-203 (2010) Which DFT functional performs well in the calculation of methylcobalamin? Comparison of the B3LYP and BP86 functionals and evaluation of the impact of empirical dispersion correction.Hajime Hirao The journal of physical chemistry. A, 115(33), 9308-9313 (2011-08-03) Electronic structure of cofactor-substrate reactant complex involved in the methyl transfer reaction catalyzed by cobalamin-dependent methionine synthase.Neeraj Kumar et al.The journal of physical chemistry. B, 115(20), 6722-6731 (2011-05-05) Ultrafast infrared spectral fingerprints of vitamin B12 and related cobalamins.Alex R Jones et al.The journal of physical chemistry. A, 116(23), 5586-5594 (2012-05-23) Leukoencephalopathies associated with disorders of cobalamin and folate metabolism.Bridget Wilcken Seminars in neurology, 32(1), 68-74 (2012-03-17) [Clinical trials of ultra-high-dose methylcobalamin in ALS].Yuishin Izumi et al.Brain and nerve = Shinkei kenkyu no shinpo, 59(10), 1141-1147 (2007-11-01) Inhibition of nitric oxide synthase by cobalamins and cobinamides.J Brice Weinberg et al.Free radical biology & medicine, 46(12), 1626-1632 (2009-03-31) [Electrophysiological changes in diabetic peripheral neuropathy patients of different Chinese medicine syndrome types intervened by naoxintong and mecobalamin].Pei-ji Huang et al.Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 31(8), 1051-1056 (2011-09-14) Methylcobalamin: a potential vitamin of pain killer.Ming Zhang et al.Neural plasticity, 2013, 424651-424651 (2014-01-24) Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.Luciana Hannibal et al.Molecular genetics and metabolism, 97(4), 260-266 (2009-05-19) Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.Karl Gruber et al.Chemical Society reviews, 40(8), 4346-4363 (2011-06-21) Case of Ramsay-Hunt syndrome associated with dysphagia.Fusheng Wang et al.The Journal of dermatology, 38(12), 1195-1197 (2011-05-07) Inborn errors of cobalamin absorption and metabolism.David Watkins et al.American journal of medical genetics. Part C, Seminars in medical genetics, 157C(1), 33-44 (2011-02-12) Position-specific isotope analysis of the methyl group carbon in methylcobalamin for the investigation of biomethylation processes.Oliver Wuerfel et al.Analytical and bioanalytical chemistry, 405(9), 2833-2841 (2013-01-18) Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin.Kiyoshi Okada et al.Neuroscience letters, 495(3), 201-204 (2011-04-05)

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