Remarks
Description for route of synthesis:
Under inert gas protection, using tetrahydrofuran as the solvent, 8-benzyloxy-5- (2-bromoacetyl) -2-hydroxyquinoline is mixed with (R) -2-methyl-CBS oxazolborane. After cooling to low temperature, borane dimethyl sulfide complex is slowly added for asymmetric carbonyl reduction reaction; After the reaction is complete, the target chiral product is obtained by quenching, extraction, washing, drying, and purification through column chromatography or recrystallization.
Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
More
