Melting point	127 ºC
Flash point	230 ºC

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Source	SDS/MSDS Samples
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Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.Romina Nassini et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(12), 4904-4916 (2010-08-20) Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.Brett A Howell et al.Toxicology letters, 226(2), 163-172 (2014-02-25) Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.Rosalind E Jenkins et al.Proteomics, 8(2), 301-315 (2008-01-19) A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.Kiyoshi Fukuhara et al.Drug metabolism and pharmacokinetics, 26(4), 399-406 (2011-06-15) In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.Dimitrios Tsikas et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(17-18), 1476-1484 (2011-03-01) Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes.Ravindra Babu Pingili et al.Chemico-biological interactions, 302, 123-134 (2019-02-23) A novel approach for the determination of paracetamol based on the reduction of N-acetyl-p-benzoquinoneimine formed on the electrochemically treated pencil graphite electrode.Ali Özcan et al.Analytica chimica acta, 685(1), 9-14 (2010-12-21) The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.Ian M Copple et al.Hepatology (Baltimore, Md.), 48(4), 1292-1301 (2008-09-12) A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.Sonya V Iverson et al.Free radical biology & medicine, 63, 369-380 (2013-06-08) A reliable method of liquid chromatography for the quantification of acetaminophen and identification of its toxic metabolite N-acetyl-p-benzoquinoneimine for application in pediatric studies.Carmen Flores-Pérez et al.Biomedical chromatography : BMC, 25(7), 760-766 (2010-09-30) Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using a glutathione conjugated 96-well plate.Xiang Ma et al.Bioconjugate chemistry, 21(1), 46-55 (2009-12-05) TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.David A Andersson et al.Nature communications, 2, 551-551 (2011-11-24) An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.Jeffrey L Woodhead et al.The Journal of pharmacology and experimental therapeutics, 342(2), 529-540 (2012-05-18) [Dosing time based on molecular mechanism of biological clock of hepatic drug metabolic enzyme].Naoya Matsunaga Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(11), 1357-1365 (2009-11-03) Combination of electrochemistry and nuclear magnetic resonance spectroscopy for metabolism studies.Hannah Simon et al.Analytical chemistry, 84(20), 8777-8782 (2012-09-14) Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice.Shingo Arakawa et al.The Journal of toxicological sciences, 37(3), 595-605 (2012-06-13) SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.Zhongping Lu et al.EMBO reports, 12(8), 840-846 (2011-07-02) Cross-linking of protein molecules by the reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, and related quinoid compounds.A J Streeter et al.Advances in experimental medicine and biology, 197, 727-737 (1986-01-01) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.J E Laine et al.Xenobiotica; the fate of foreign compounds in biological systems, 39(1), 11-21 (2009-02-17) An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human.Hui Ting Chng et al.Journal of biomolecular screening, 17(7), 974-986 (2012-05-31) Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.Kang Kwang Lee et al.Hepatology (Baltimore, Md.), 61(1), 326-336 (2014-08-22) Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.Su Ching Tan et al.Toxicology letters, 180(3), 174-181 (2008-07-01) Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes.Angela S Burke et al.Chemical research in toxicology, 23(7), 1286-1292 (2010-06-29) Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.Laura P James et al.Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1779-1784 (2009-05-15) Plasmid DNA linearization in the antibacterial action of a new fluorescent Ag nanoparticle-paracetamol dimer composite.Amaresh Kumar Sahoo et al.Nanoscale, 3(10), 4226-4233 (2011-09-08) An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review.Bellamkonda Bosebabu et al.Mini reviews in medicinal chemistry, 20(11), 988-1000 (2020-03-14) Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.Johannes S Hoos et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859(2), 147-156 (2007-10-05) Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.Gregg V Crichlow et al.Biochemistry, 48(1), 132-139 (2008-12-19) Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.S Koling et al.International journal of clinical pharmacology and therapeutics, 45(9), 496-503 (2007-10-03) Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.Jean-Matthieu Prot et al.Toxicology and applied pharmacology, 259(3), 270-280 (2012-01-11)

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