Density	1.33

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Source	SDS/MSDS Samples
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Stereospecific synthesis of m-Hydroxymexiletine enantiomers.Alessia Catalano et al.Drug metabolism letters, 6(3), 182-186 (2012-11-13) Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.Alessia Catalano et al.Journal of medicinal chemistry, 55(3), 1418-1422 (2011-12-24) Drug-induced hypersensitivity syndrome complicated with concurrent fulminant type 1 diabetes mellitus and Hashimoto's thyroiditis.Yusuke Minegaki et al.International journal of dermatology, 52(3), 355-357 (2013-02-19) Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.Da Shi et al.Acta pharmacologica Sinica, 33(5), 710-716 (2012-05-05) Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.Andrias O O'Reilly et al.PloS one, 7(7), e41667-e41667 (2012-08-01) Sivy J, et al. Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991) Long QT syndrome with nocturnal cardiac events caused by a KCNH2 missense mutation (G604S).Akinori Sato et al.Internal medicine (Tokyo, Japan), 51(14), 1857-1860 (2012-07-24) An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.Alessia Catalano et al.Drug metabolism letters, 6(2), 124-128 (2012-08-02) Primary erythromelalgia in a 12-year-old boy: positive response to sodium channel blockers despite negative SCN9A mutations.A Jakob et al.Klinische Padiatrie, 224(5), 309-312 (2011-12-16) Deracemization of mexiletine biocatalyzed by omega-transaminases.Dominik Koszelewski et al.Organic letters, 11(21), 4810-4812 (2009-09-30) Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels.Michela De Bellis et al.Biophysical journal, 104(2), 344-354 (2013-02-28) Wide QRS Tachycardia in a young patient.Robert J Hariman et al.Archives of internal medicine, 172(7), 537-537 (2012-04-12) Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.Shinichi Niwano et al.International heart journal, 53(2), 139-145 (2012-06-13) Pharmacological therapies for muscular dystrophies.Hoda Abdel-Hamid et al.Current opinion in neurology, 25(5), 604-608 (2012-09-04) Enantioselective drug-protein interaction between mexiletine and plasma protein.Lushan Yu et al.The Journal of pharmacy and pharmacology, 64(6), 792-801 (2012-05-11) Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.Jeffrey M Statland et al.JAMA, 308(13), 1357-1365 (2012-10-04) Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.Juan Zhao et al.The Journal of physiology, 590(11), 2629-2644 (2012-01-18) Atrial selectivity in Na+channel blockade by acute amiodarone.Tomoyuki Suzuki et al.Cardiovascular research, 98(1), 136-144 (2013-01-24) Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).Kadir Batcioglu et al.Basic & clinical pharmacology & toxicology, 111(2), 137-141 (2012-03-21) Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.Jaya R Trivedi et al.Brain : a journal of neurology, 136(Pt 7), 2189-2200 (2013-06-19) Detecting drug-induced prolongation of the QRS complex: new insights for cardiac safety assessment.C Cros et al.Toxicology and applied pharmacology, 265(2), 200-208 (2012-10-18) Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.Sunao Ito et al.The Journal of pharmacology and experimental therapeutics, 342(1), 53-60 (2012-03-31) Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a practical strategy in the preparation of (R)-mexiletine and (S)-propranolol.Arghya Sadhukhan et al.Chemistry (Weinheim an der Bergstrasse, Germany), 18(17), 5256-5260 (2012-03-17) Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome.Yuanfeng Gao et al.Circulation. Arrhythmia and electrophysiology, 6(3), 614-622 (2013-04-13) Mexiletine for treatment of myotonia: a trial triumph for rare disease networks.Eric P Hoffman et al.JAMA, 308(13), 1377-1378 (2012-10-04) Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.Angela K Clouse et al.Urology, 79(6), 1410-1410 (2012-04-14) Erythromelagia: a rare and hard-to-treat condition: a 9-year-old boy responsive to intravenous lidocaine and oral mexilitene.Francisca Elgueta et al.Pain medicine (Malden, Mass.), 14(2), 311-312 (2013-02-02) Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.Cecile Terrenoire et al.The Journal of general physiology, 141(1), 61-72 (2013-01-02)

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