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Peer-Reviewed Papers

An investigation of the correlation between blood concentration of mizoribine and its efficacy in treatment of rheumatoid arthritis based on indices of drug survival and improvement in DAS28-CRP.Hideo Ohtsubo et al.Modern rheumatology, 22(6), 837-843 (2012-03-07) Effect of salt intake on bioavailability of mizoribine in healthy Japanese males.Kazuya Ishida et al.Drug metabolism and pharmacokinetics, 28(1), 75-80 (2012-07-21) Effect of single-dose oral mizoribine pulse therapy twice per week for frequently relapsing steroid-dependent nephrotic syndrome.Mikiya Fujieda et al.Clinical nephrology, 78(1), 40-46 (2012-06-27) A case of acute kidney injury with marked hyperuricemia during mizoribine administration.Tomoya Nishino et al.Internal medicine (Tokyo, Japan), 51(10), 1239-1243 (2012-06-13) GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin E.Kohei Miyazaki et al.Clinical nephrology, 77(4), 261-266 (2012-03-27) Napoli, K.L. J. Inter. Fed. Clin. Chem., 4, 15-15 (1992) The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme.Frédéric Picard-Jean et al.PloS one, 8(1), e54621-e54621 (2013-01-26) Topical Application of Mizoribine Suppresses CD4+ T-cell-Mediated Pathogenesis in Murine Dry EyeZhang X, et al. Investigative Ophthalmology & Visual Science, 58(14), 6056-6064 (2017) Long-term multidrug therapy in an adolescent patient with proliferative lupus nephritis: a trial of less cytotoxic therapy.Tomomi Aizawa-Yashiro et al.Clinical nephrology, 78(4), 332-334 (2012-08-03) Mizoribine, tacrolimus, and corticosteroid combination therapy successfully induces remission in patients with lupus nephritis.Hidetoshi Kagawa et al.Clinical and experimental nephrology, 16(5), 760-766 (2012-04-12) Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation.Kazuya Ishida et al.Clinical and experimental nephrology, 16(5), 799-804 (2012-03-01) Mizoribine: mode of action and effects in clinical use.Shumpei Yokota Pediatrics international : official journal of the Japan Pediatric Society, 44(2), 196-198 (2002-03-19) Nephrotic syndrome and mizoribine in children.Masataka Honda Pediatrics international : official journal of the Japan Pediatric Society, 44(2), 210-216 (2002-03-19) Mizoribine for crescentic glomerulonephritis with sarcoidosis: effectiveness not only for urinalysis abnormalities but also for hilar lymph node enlargement.Maki Kabara et al.Modern rheumatology, 23(1), 146-150 (2012-02-22) Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis.Eiko Nishi et al.Modern rheumatology, 23(1), 97-103 (2012-04-25) Mizoribine: a new approach in the treatment of renal disease.Yukihiko Kawasaki Clinical & developmental immunology, 2009, 681482-681482 (2010-01-07) Mizoribine as sole immunosuppressive agent in islet xenotransplantation models: a candidate immunosuppressant causing no adverse effects on islets.Michitoshi Yamashita et al.Cell transplantation, 21(2-3), 535-545 (2012-07-17) Inhibition of expression of cyclin A in human B cells by an immunosuppressant mizoribine.S Hirohata et al.Journal of immunology (Baltimore, Md. : 1950), 155(11), 5175-5183 (1995-12-01) Characterization of the novel Trypanosoma brucei inosine 5'-monophosphate dehydrogenase.Tomoaki Bessho et al.Parasitology, 140(6), 735-745 (2013-02-02) Role of mizoribine in renal transplantation.Kazuo Tsuzuki Pediatrics international : official journal of the Japan Pediatric Society, 44(2), 224-231 (2002-03-19) Mizoribine treatment for antihistamine-resistant chronic autoimmune urticaria.Takashi Hashimoto et al.Dermatologic therapy, 25(4), 379-381 (2012-09-07) GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis.C V Catapano et al.Molecular pharmacology, 47(5), 948-955 (1995-05-01) Influence of serum uric acid levels in response to the conversion from mycophenolate mofetil to mizoribine in kidney transplant recipients.X Ding et al.Transplantation proceedings, 45(1), 190-193 (2013-02-05) Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis.Syuji Takei Pediatrics international : official journal of the Japan Pediatric Society, 44(2), 205-209 (2002-03-19) Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis.Masaki Shimizu et al.Rheumatology (Oxford, England), 53(8), 1530-1532 (2014-03-13) [Mizoribine].Hirobumi Kondo et al.Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 5, 708-712 (2005-06-16) Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancersHuang F, et al. Cell Metabolism, 28(3), 369-382 (2018) Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect.R Håkanson et al.Regulatory peptides, 31(1), 75-82 (1990-10-29) Mizoribine and mycophenolate mofetil.H Ishikawa Current medicinal chemistry, 6(7), 575-597 (1999-07-03) Chronopharmacology of mizoribine in collagen-induced arthritis rats.Yuko Kanasaki et al.Journal of pharmacological sciences, 120(2), 112-120 (2012-09-29) [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine].Tetsuji Sawada Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(10), 2929-2935 (2011-12-20) Pharmacokinetics of mizoribine in adult living donor liver transplantation.M Shinoda et al.Transplantation proceedings, 44(5), 1329-1335 (2012-06-06) The beneficial effect of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids on CMV infection in renal transplant recipients.Norio Yoshimura et al.Clinical and experimental nephrology, 17(1), 127-133 (2012-09-27) Determination of mizoribine in human plasma using high-performance liquid chromatography: application to a pharmacokinetic study in Chinese renal transplant recipients.B Ren et al.Drug research, 63(7), 376-381 (2013-04-16) Efficacy and safety of multitarget therapy with mizoribine and tacrolimus for systemic lupus erythematosus with or without active nephritis.A Nomura et al.Lupus, 21(13), 1444-1449 (2012-08-25) [Hyperuricemia and acute kidney injury following kidney transplantation : a case report].Shigeaki Nakazawa et al.Hinyokika kiyo. Acta urologica Japonica, 59(2), 103-106 (2013-04-05) Monoclonal antibodies to lipopolysaccharide antigens of Salmonella enterica serotype Typhimurium DT104.Jennifer Ronholm et al.Hybridoma (2005), 30(1), 43-52 (2011-04-07) [A case of rheumatoid arthritis/Sjogren's syndrome with acute renal failure due to hyperuricemia associated with mizoribine therapy].Hiroki Tanaka et al.Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 27(3), 171-176 (2004-08-05) Childhood nephrotic syndrome--current and future therapies.Larry A Greenbaum et al.Nature reviews. Nephrology, 8(8), 445-458 (2012-06-13) The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats.Koji Sakuraya et al.The Journal of urology, 191(4), 1139-1146 (2013-10-22) Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 stimulated by thrombin.Hideaki Yamabe et al.Biological & pharmaceutical bulletin, 35(5), 705-708 (2012-06-13) Experiences of high-dose mizoribine as antimetabolite immunosuppressants for kidney transplantation.N Nakamura et al.Transplantation proceedings, 44(1), 150-153 (2012-02-09) Maintenance therapy with single-daily, high-dose mizoribine after cyclophosphamide therapy for prepubertal boys with severe steroid-dependent nephrotic syndrome.Shuichiro Fujinaga et al.Clinical nephrology, 78(3), 251-252 (2012-05-01) The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review.Xin Zhang et al.Transplant immunology, 28(2-3), 106-111 (2013-01-15) Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus.Takashi Hashimoto et al.Dermatologic therapy, 25(4), 382-385 (2012-09-07)

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