Melting point	-75 ºC
Water Solubility	Insoluble
Boiling point	205 ºC
Flash point	65 ºC
Density	0.863
Refractive index	1.487-1.489

SDS/MSDS	S23;S24/25

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells.Kun-Che Chang et al.Chemico-biological interactions, 276, 149-154 (2017-02-01) Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.Malkhey Verma et al.European journal of pharmacology, 584(2-3), 213-221 (2008-03-08) Synthesis and aldose reductase inhibitory activities of novel O-substituted hydroxyphenylacetic acid derivatives.Dietmar Rakowitz et al.Archiv der Pharmazie, 339(10), 547-558 (2006-09-30) A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy.R J Young et al.Diabetes, 32(10), 938-942 (1983-10-01) Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages.Kota V Ramana et al.Cytokine, 36(3-4), 115-122 (2006-12-19) Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase.Thomas Dschietzig et al.Shock (Augusta, Ga.), 30(2), 189-196 (2007-12-20) Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.Kun-Che Chang et al.Chemico-biological interactions, 234, 254-260 (2014-12-03) Aldose reductase inhibitors attenuate β-amyloid-induced TNF-α production in microlgia via ROS-PKC-mediated NF-κB and MAPK pathways.Xiao-Min Song et al.International immunopharmacology, 50, 30-37 (2017-06-18) Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis.Aramati B M Reddy et al.Cytokine, 48(3), 170-176 (2009-08-08) Synthesis and biological evaluation of 2'-oxo-2,3-dihydro-3'H- spiro[chromene-4,5'-[1,3]oxazolidin]-3'yl]acetic acid derivatives as aldose reductase inhibitors.Simona Rapposelli et al.Archiv der Pharmazie, 344(6), 372-385 (2011-02-15) Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.Holger Steuber et al.Journal of molecular biology, 369(1), 186-197 (2007-04-10) Role of aldose reductase in diabetes-induced retinal microglia activation.Kun-Che Chang et al.Chemico-biological interactions, 302, 46-52 (2019-01-27) Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.Kun-Che Chang et al.Investigative ophthalmology & visual science, 55(5), 2853-2861 (2014-03-29) The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy.Chiara Gerhardinger et al.Diabetes, 58(7), 1659-1667 (2009-04-30) Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition.Kota V Ramana et al.Circulation, 114(17), 1838-1846 (2006-10-13) Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity.Wei Li et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 114, 108794-108794 (2019-04-05) Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.Sanjay Srivastava et al.Circulation research, 105(8), 793-802 (2009-09-05) Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.Trevor Askwith et al.Experimental neurology, 233(1), 154-162 (2011-09-29) In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.Rosanna Maccari et al.Bioorganic & medicinal chemistry letters, 21(1), 200-203 (2010-12-07) Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.Karin Kaiserova et al.The Journal of biological chemistry, 283(14), 9101-9112 (2008-01-29) Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells.Umesh C S Yadav et al.Experimental eye research, 90(5), 555-563 (2010-02-09) Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery.Leonid M Zukin et al.Investigative ophthalmology & visual science, 59(8), 3591-3598 (2018-07-20) A new approach to control the enigmatic activity of aldose reductase.Antonella Del-Corso et al.PloS one, 8(9), e74076-e74076 (2013-09-11) Phenolic marine natural products as aldose reductase inhibitors.Sonia Manzanaro et al.Journal of natural products, 69(10), 1485-1487 (2006-10-28) Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells.Tao Jiang et al.Nephrology (Carlton, Vic.), 11(2), 105-112 (2006-05-04) Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase.Zhiguo Wang et al.Journal of molecular graphics & modelling, 28(2), 162-169 (2009-07-21) Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity.D A Greene et al.Diabetes, 33(8), 712-716 (1984-08-01) Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells.Agnieszka Pladzyk et al.Investigative ophthalmology & visual science, 47(12), 5395-5403 (2006-11-24) N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.Susanna Nencetti et al.Bioorganic & medicinal chemistry, 25(12), 3068-3076 (2017-04-11) Pathways of 4-Hydroxy-2-Nonenal Detoxification in a Human Astrocytoma Cell Line.Eleonora Peroni et al.Antioxidants (Basel, Switzerland), 9(5) (2020-05-10) Review of myo-inositol and sorbinil studies.R S Clements Clinical physiology (Oxford, England), 5 Suppl 5, 90-93 (1985-01-01) Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice.Umesh C S Yadav et al.PloS one, 4(8), e6535-e6535 (2009-08-07) The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.Muthenna Puppala et al.PloS one, 7(4), e31399-e31399 (2012-04-10) Prevention of posterior capsular opacification through aldose reductase inhibition.Umesh C S Yadav et al.Investigative ophthalmology & visual science, 50(2), 752-759 (2008-11-18) Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle.Ravinder Tammali et al.Endocrinology, 151(5), 2140-2150 (2010-03-24) Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.Sally A Madsen-Bouterse et al.Reviews in endocrine & metabolic disorders, 9(4), 315-327 (2008-07-26) Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy.Claire Demiot et al.Diabetes, 55(5), 1478-1483 (2006-04-29) High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.Emily Schartner et al.Experimental neurology, 309, 134-147 (2018-08-14) Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.Ravinder Tammali et al.Cancer research, 66(19), 9705-9713 (2006-10-05)

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